Navigation Links
Montana State grad's work helps diagnose skin cancer without a biopsy
Date:3/30/2009

BOZEMAN -- A recent Montana State University master's graduate is working with doctors at Vanderbilt Medical Center in Tennessee to build a handheld laser microscope that could someday reduce the number of biopsies needed to diagnose skin cancer.

Suspicious spots on the skin often prompt dermatologists to remove skin samples for analysis. These procedures are currently the best way to diagnose skin cancers, said Chris Arrasmith, who recently earned his master's degree and now works as a researcher in MSU's electrical engineering department.

But biopsies are invasive procedures that are often painful. Millions are conducted each year in the United States, and according to the American Cancer Society, most of those biopsies -- as many as 80 percent for some types of cancers -- come back negative.

The handheld microscope could help doctors get a better idea when biopsies are absolutely necessary. That would cut down on the number of biopsies that have to be performed and streamline the process of diagnosing cancers, Arrasmith said.

"Any combination of tools we can provide to enable early detection of any kind of disease is a good thing," said Arrasmith, 25.

Like most microscopes, the MSU-Vanderbilt device uses lenses to look at a patient's skin, but instead of illuminating the skin with normal white light, the device uses laser light.

The laser light is used to form an image of the skin's cellular structure, and it monitors the way a patient's cells change the reflected laser light, Arrasmith said. Those changes to the light can tell scientists the chemical composition of the skin cells -- a process called spectroscopy.

"Within the microscope's image, we can select an area of interest, and from that we can take a spectrum and get chemical data," Arrasmith said.

Doctors would then compare that chemical signature to a database containing the chemical signatures of known cancers to see whether the patient's cells are cancerous.

The project, which Arrasmith began working on when he was an undergraduate at MSU, is funded by a five-year grant from the National Institute of Biomedical Imaging and Bioengineering, part of the National Institutes of Health. The NIBIB focuses on researching new biomedical imaging devices and techniques to improve the detection, treatment and prevention of disease.

The $1.79 million grant is administered by Vanderbilt. MSU will receive $500,000 from the grant over all five years. That money covered, among other things, the cost of the microscope itself and Arrasmith's graduate tuition.

David Dickensheets, an associate professor of electrical and computer engineering at MSU and adviser to Arrasmith's work, said other labs have built microscopes that work on the same principles, but they have been desktop instruments that still required skin samples to be taken from patients.

Shrinking the microscope takes advantage of MSU's expertise in a field called micro-electrical-mechanical systems, or MEMS.

The handheld microscope contains a tiny mirror made of silicon that scans the laser beam across the skin, Dickensheets said. This allows the microscope to form an image and lets it look at cells beneath the patient's outer skin layer.

Merging MSU's expertise in microscopy and MEMS with Vanderbilt's spectroscopy research will produce a device that could one day find its way into dermatology clinics around the world, Dickensheets said.

"We think that microscopic imaging of cell structure combined with the chemical specificity provided by spectroscopy is the real key to making it a useful tool," Dickensheets said.

For Arrasmith, who has worked on the microscope since 2006, the approaching end of his time at MSU is both satisfying and bittersweet.

It's satisfying, he said, because he's been able to build a prototype microscope that's now being tested at Vanderbilt's medical clinics. It's bittersweet, he said, because he knows he won't be around to see the finished second-generation model, which he hopes will be about the size of a chalkboard eraser.

"As a person who likes to see things from start to completion, it's difficult to leave in the middle of a long project like this," he said.

But he said the experience he's gained from having a hand in every aspect of the project -- from theory and design to machining parts -- will give him a leg up in searching for an engineering job after he leaves MSU.

"This project has really allowed me to see how things come together from multiple facets of design," he said. "What I'm taking away from MSU is a general knowledge base that I can apply to any other situation."


'/>"/>

Contact: Michael Becker
becker@montana.edu
406-994-5140
Montana State University
Source:Eurekalert

Related biology news :

1. Montana State team finds Yellowstone alga that detoxifies arsenic
2. Montana State partnership receives $66.9M for carbon sequestration
3. Montana State researchers receive grant to study algae as a source of biofuel
4. Montana State University researchers find gene that regulates molds resistance to drugs
5. International experts collect alpine fungi in Beartooth Mountains of Montana
6. Sweets make young horses harder to train in Montana State study
7. Montana State researchers release guide to noninvasive carnivore research
8. Bird watchers, space technology come together in Montana State University study
9. Dinosaur diggers bring mobile lab, new techniques to Eastern Montana
10. Montana State University researchers map iron transport protein
11. Montana State University research reaches Supreme Court of India
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2017)... 2017 Australian stem cell and regenerative medicine ... signed an agreement with the Monash Lung Biology Network, ... Institute and Department of Pharmacology at Monash University, ... study to support the use of Cymerus™ mesenchymal stem ... Asthma is a chronic, long term lung condition ...
(Date:2/28/2017)... 27. Februar 2017  EyeLock LLC, ein marktführendes Unternehmen ... erstklassige biometrische Lösung zur Iris-Erkennung auf der ... LTE auf dem Mobile World Congress 2017 ... in Halle 3, Stand 3E10, vorstellen. ... Qualcomm Haven™ – eine Kombination aus Hardware, ...
(Date:2/22/2017)... -- With the biometrics market to exceed $10 ... that innovative and agile startups must incorporate into ... changing competitive landscape: multifactor authentication (MFA), point-of-sale (PoS), ... "Companies can no longer afford to cut corners ... Pavlakis , Industry Analyst at ABI Research. "Pairing ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... 22, 2017 Oramed Pharmaceuticals Inc. (NASDAQ: ... www.oramed.com ), a clinical-stage pharmaceutical company ... systems, announced today that Dr. Miriam Kidron ... presentation titled, "Oral Insulin for Diabetes Treatment: Bypassing ... Institute,s Oligonucleotide and Peptide Therapeutics (OPT) Boston Conference in ...
(Date:3/22/2017)... , March 22, 2017 The ... states a research report by Transparency Market Research (TMR). ... Amgen Inc., and AbbVie Inc., accounted for a share ... prominent players in this market are focusing aggressively on ... portfolio, which is likely to lead to market consolidation ...
(Date:3/22/2017)... TORONTO , March 22, 2017 /PRNewswire/ - ... Therapeutics (the "Company" or "Propellon"), a start-up created ... WDR5-targeted anti-cancer therapeutics. FACIT,s investment, combined with non-dilutive ... lead program. The seed funding enables Propellon to ... position the Company for financing and/or entering a ...
(Date:3/22/2017)... March 22, 2017   VWR ... of product and service solutions to laboratory ... has acquired EPL Archives, Inc., an international ... the entire regulated product research, development and ... storage and ancillary services. EPL Archives is ...
Breaking Biology Technology: