Navigation Links
Montana State University team surprised by results of lung, mold study
Date:8/4/2011

BOZEMAN, Mont. Researchers led by Montana State University have found a surprising condition that occurs in the lungs after an invasion of a common mold that can cause deadly infections in humans.

In the most oxygen-rich environment in the body the lungs the scientists discovered a shortage of oxygen. The shortage resulted from inflammation and invasive growth of the mold, which greatly reduced the oxygen available to the pathogenic mold Aspergillus fumigatus.

The mold is generally found in hay, soils and compost piles and can cause a variety of lung infections when inhaled by humans. The most lethal of those infections is invasive aspergillosis, which can kill 30 to 90 percent of its victims depending on the patient population. Most susceptible are people who have had organ transplants, HIV, chemotherapy or other medical treatments that weaken their ability to fight off infection.

"We think this (the lack of oxygen) is a really big stress on the pathogen," said Nora Grahl, a doctoral candidate at MSU.

Grahl led the study that's adding knowledge to the field of infectious disease and was published in the July 21 issue of "PLoS Pathogens." Based in Dr. Robert Cramer's laboratory in MSU's Department of Immunology and Infectious Diseases, the study was the first to show a strong link between hypoxia, or low oxygen levels in the lungs, and fungal infections, Grahl said. She added that the research was unique because little research has been done on the microenvironments encountered by Aspergillus fumigatus in such detail during infection.

The study was conducted in mice and showed a variety of ways that the lungs and mold respond to each other. The scientists noted, for example, that low levels of oxygen are just one of many challenges that mold has to overcome before it can cause a lung infection. When the shortage occurs, though, microbes may adapt through fermentation or other changes in metabolism. An important finding of the study was that the mold's fermentation could also influence the host immune response to the pathogen.

Cramer said most microbes can use fermentation to generate energy during hypoxia, but Grahl has also found mutant strains of the mold that use respiration instead. As a result, the researchers are interested in continuing to study respiration as it relates to Aspergillus fumigatus pathogenesis.

Grahl said she learned that the "PLoS Pathogens" paper her first published paper as lead author -- had been accepted for publication while attending the fourth Federation of the Societies of Biochemistry and Molecular Biology (FEBS) Conference on Human Fungal Pathogens in France. After presenting her research there in May, she won an Outstanding Young Investigator Award for her work.


'/>"/>

Contact: Evelyn Boswell
evelynb@montana.edu
406-994-5135
Montana State University
Source:Eurekalert

Related biology news :

1. Montana State University researchers find gene that regulates molds resistance to drugs
2. Montana State researchers receive grant to study algae as a source of biofuel
3. Montana State partnership receives $66.9M for carbon sequestration
4. Montana State team finds Yellowstone alga that detoxifies arsenic
5. Montana State grads work helps diagnose skin cancer without a biopsy
6. New dinosaur species from Montana
7. Montana State researcher discovers that bile sends mixed signals to E. coli
8. Montana State University historian wins prize for book on Montana, Utah copper mines
9. Montana State grad student to study unique soil around Yellowstone hot springs
10. Montana State researchers say Triceratops, Torsaurus were same dinosaur at different stages
11. Montana State University offers 6 new biomedical technologies for licensing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... , March 21, 2017   Neurotechnology , ... recognition technologies, today announced the release of the ... which provides improved facial recognition using up to ... a single computer. The new version uses deep ... accuracy, and it utilizes a Graphing Processing Unit ...
(Date:3/16/2017)... - Against identity fraud with DERMALOG solutions "Made in Germany "  ... ... multi-biometric solutions provide a crucial contribution against identity fraud. (PRNewsFoto/Dermalog Identification Systems) ... Used combined in one project, multi-biometric solutions provide a crucial contribution against identity ... ...
(Date:3/7/2017)...   HireVue , the leading provider of video ... best talent, faster, today announced the additions of ... Diana Kucer as Chief Marketing Officer (CMO). ... poised to drive continued growth in the company,s new ... record bookings in 2017. "Companies worldwide turn ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... March 22, 2017 /PRNewswire/ - FACIT announced a ... or "Propellon"), a start-up created by FACIT focused ... FACIT,s investment, combined with non-dilutive capital, achieves a ... seed funding enables Propellon to accelerate the nomination ... for financing and/or entering a strategic partnership for ...
(Date:3/22/2017)... , March 22, 2017   ... independent provider of product and service solutions ... that it has acquired EPL Archives, Inc., ... customers across the entire regulated product research, ... sample, document storage and ancillary services. EPL ...
(Date:3/22/2017)... Bahama (PRWEB) , ... March 21, 2017 , ... Okyanos ... educational seminar as part of their live events series, “Stem Cell Therapy: The Next ... cell facility under the 2013 Stem Cell Research and Therapy Act, Okyanos ...
(Date:3/22/2017)... ... ... Benchworks CEO Thad L. Bench Sr. will participate in the ... Diego. The event is a gathering of executive leadership from companies in the pharmaceutical, ... will also participate in the forum. Participants will discuss the future of the life ...
Breaking Biology Technology: