Montana State University researchers find gene that regulates mold's resistanc... ( Cramer said. These drugs target the s...)

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Montana State University researchers find gene that regulates mold's resistance to drugs

Date:11/7/2008

," Cramer said. "These drugs target the synthesis of ergosterol. ... If you get rid of ergosterol, you kill the mold."

Sven Willger, a postdoctoral researcher in Cramer's lab and first author of the PLoS Pathogens paper, said the absence of srbA changed the way the mold cells grew. Instead of growing from the tip, they branched off from several other locations. The confusion became apparent under a transmission electron microscope.

The researchers said in their paper that they demonstrated for the first time that it is significant that invasive molds adapt to reduced oxygen levels during infection.

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Contact: Evelyn Boswell
evelynb@montana.edu
406-994-5135
Montana State University
Source:Eurekalert

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