Navigation Links
Montana State University researchers find gene that regulates mold's resistance to drugs
Date:11/7/2008

BOZEMAN, Mont. -- Montana State University scientists concerned about lethal mold infections have found a gene that regulates the mold's resistance to drugs.

The gene, called srbA, allows molds to thrive during infections even when inflammation reduces its oxygen supply, said Robert Cramer, senior author of a paper published in the Nov. 7 issue of PLoS Pathogens. When the gene is removed, the mold becomes much more vulnerable to lack of oxygen and can no longer grow to cause disease.

The gene is found in humans and molds, but the researchers studied it in a common mold called Aspergillus fumigatus, said Cramer, assistant professor of fungal pathogenesis in MSU's Department of Veterinary Molecular Biology. A. fumigatus can invade the lungs and cause dangerous diseases, including Invasive Pulmonary Aspergillosis. Patients with a compromised immune system, especially organ transplant patients, are particularly at risk.

"The incidence of potentially lethal infections caused by normally benign molds has increased tremendously over the last two decades," the researchers wrote.

The scientists discovered the value of srbA after creating a mutant version of the fungus without the gene, Cramer said. Tests showed that the loss of srbA affected 87 genes in the fungus. Without the gene, the mutant could no longer grow when oxygen was limited, which occurs during mold infections. The mutant mold without srbA could no longer cause disease. It was also highly susceptible to antifungal drugs, more vulnerable than the original, complete mold.

Further study showed that srbA plays a critical role in the making of ergosterol, the fungal-form of cholesterol, Cramer said. The gene in humans is associated with the making of cholesterol. Ergosterol and cholesterol are necessary components of cell membranes.

"The reason we're interested is because ergosterol is a target for most of the antifungal drugs that are available
'/>"/>

Contact: Evelyn Boswell
evelynb@montana.edu
406-994-5135
Montana State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. International experts collect alpine fungi in Beartooth Mountains of Montana
2. Sweets make young horses harder to train in Montana State study
3. Montana State researchers release guide to noninvasive carnivore research
4. Bird watchers, space technology come together in Montana State University study
5. Dinosaur diggers bring mobile lab, new techniques to Eastern Montana
6. Montana State University researchers map iron transport protein
7. Montana State University research reaches Supreme Court of India
8. Montana State researchers study spread of lake trout in Glacier National Park
9. Low exposure to asbestos-like mineral from Montana vermiculite may up lung disease risk
10. Antarcticas coldest, darkest season draws Montana State University researchers
11. Mongolian paleontologists with a dream come to Montana State University
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... CIE San Diego has launched an innovative ... tissue that enhances care coordination among social service and ... information; earned a second $1 million grant from the ... aging in community and; will be recognized as a ... 4-6p. CIE San Diego today announced ...
(Date:12/10/2014)... California , December 9, 2014 ... with ITN,s BCARD Platform   ... cloud-based enterprise meeting scheduling solutions for business-to-business (B2B) ... the world leader in mobile near-field communication (NFC), ...      (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , ...
(Date:12/5/2014)... , Dec. 4, 2014  Tute Genomics, a ... $2.3 million in Series A1 funding led by UK-based ... also participated in the investment round. "We ... healthcare community adopts next-generation sequencing and seeks new approaches ... Reid Robison , MD MBA, and CEO of ...
Breaking Biology News(10 mins):Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3
... showed that they could cut the lives of disease-carrying mosquitoes ... from fruit flies. Now, a new report in the December ... suggests that their strategy might do one better: The Wolbachia ... viruses that are a growing threat to humans, including those ...
... Scientists have shown for the first time that insects, ... They made the discovery thanks to high-speed video cameras ... that they used to film desert locusts stepping along ... new light on insects, ability to perform complex tasks, such ...
... Glaciers along the Gulf of Alaska are enriching stream and ... carbon contained in glacial runoff, researchers from four universities and ... issue of the journal Nature *. In ... Environmental Science Program at the University of Alaska Southeast, set ...
Cached Biology News:New tool in the fight against mosquito-borne disease: A microbial 'mosquito net' 2Ladder-walking locusts show big brains aren't always best 2Glacier melt adds ancient edibles to marine buffet 2
(Date:12/24/2014)... On Friday, December 19, 2014, President ... and Continuing Resolution Appropriations Act of 2015, which ... eligible to receive funding through the Congressionally Directed ... of Defense (DoD). The Hydrocephalus Association (HA), working ... is celebrating this victory for the over 1 ...
(Date:12/24/2014)... December 23, 2014 Nashville Fertility Center ... elected treasurer for the American Society for Reproductive Medicine ... and research in reproductive medicine. In his new ... on the executive board and will have a voice ... Hill has actively supported ASRM since 1984 when he ...
(Date:12/24/2014)... Dec. 23, 2014 China Biologic Products, ... a leading fully integrated plasma-based biopharmaceutical company in ... its majority-owned subsidiary, Shandong Taibang Biological Products Co. ... from the China Food and Drug Administration (the ... As previously disclosed in the Company,s public filings, ...
(Date:12/24/2014)... LOUIS , Dec. 23, 2014 ... today that the waiting period under the Hart-Scott-Rodino ... the acquisition expired on December 22, 2014, thereby ... review requirement for the acquisition of the Company ... U.S. antitrust clearance satisfies another condition to closing ...
Breaking Biology Technology:Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3
... 2011 Psoriasis is a persistent, long-lasting chronic skin ... more than 125 million individuals.  For some, it is ... On a continuing quest to find more effective ... Journal of Investigative Dermatology reported that the ...
... 14, 2011 Merriman Capital, ... (NASDAQ: MERR ), today announced that it ... Circadian Technologies Limited (ASX: CIR; OTCQX: CKDXY) as it ... http://photos.prnewswire.com/prnh/20100914/SF64919LOGO ) Circadian is an Australian biotechnology ...
... June 14, 2011 OncoSec Medical Inc. (OTCBB: ... to treat solid tumor cancers, announced today two ... the clinical operations of OncoSec,s ElectroOncology therapies. ... Dhillon, OncoSec,s President and CEO, said, "OncoSec has ...
Cached Biology Technology:Actinobac Biomed, Inc. Demonstrates In Vivo Efficacy for Psoriasis Treatment 2Merriman Capital Announces Sponsorship of Circadian Technologies on OTCQX 2Merriman Capital Announces Sponsorship of Circadian Technologies on OTCQX 3OncoSec Announces Clinical Leadership Appointments 2OncoSec Announces Clinical Leadership Appointments 3OncoSec Announces Clinical Leadership Appointments 4
... the biological data hidden in your samples with ... allows you to create your own microarray designs ... your own pace and receive delivery of your ... is a secure, online array creation application tool ...
Acetylcholinesterase (human brain, AChE)...
... meets the demands of the routine trace ... from reliable, robust and simple to use ... in the most challenging sample matrices found ... suited to the toughest analytical challenges found ...
C1-inhibitor (C1-INH)...
Biology Products: