Navigation Links
Montana State University researchers find gene that regulates mold's resistance to drugs
Date:11/7/2008

BOZEMAN, Mont. -- Montana State University scientists concerned about lethal mold infections have found a gene that regulates the mold's resistance to drugs.

The gene, called srbA, allows molds to thrive during infections even when inflammation reduces its oxygen supply, said Robert Cramer, senior author of a paper published in the Nov. 7 issue of PLoS Pathogens. When the gene is removed, the mold becomes much more vulnerable to lack of oxygen and can no longer grow to cause disease.

The gene is found in humans and molds, but the researchers studied it in a common mold called Aspergillus fumigatus, said Cramer, assistant professor of fungal pathogenesis in MSU's Department of Veterinary Molecular Biology. A. fumigatus can invade the lungs and cause dangerous diseases, including Invasive Pulmonary Aspergillosis. Patients with a compromised immune system, especially organ transplant patients, are particularly at risk.

"The incidence of potentially lethal infections caused by normally benign molds has increased tremendously over the last two decades," the researchers wrote.

The scientists discovered the value of srbA after creating a mutant version of the fungus without the gene, Cramer said. Tests showed that the loss of srbA affected 87 genes in the fungus. Without the gene, the mutant could no longer grow when oxygen was limited, which occurs during mold infections. The mutant mold without srbA could no longer cause disease. It was also highly susceptible to antifungal drugs, more vulnerable than the original, complete mold.

Further study showed that srbA plays a critical role in the making of ergosterol, the fungal-form of cholesterol, Cramer said. The gene in humans is associated with the making of cholesterol. Ergosterol and cholesterol are necessary components of cell membranes.

"The reason we're interested is because ergosterol is a target for most of the antifungal drugs that are available
'/>"/>

Contact: Evelyn Boswell
evelynb@montana.edu
406-994-5135
Montana State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. International experts collect alpine fungi in Beartooth Mountains of Montana
2. Sweets make young horses harder to train in Montana State study
3. Montana State researchers release guide to noninvasive carnivore research
4. Bird watchers, space technology come together in Montana State University study
5. Dinosaur diggers bring mobile lab, new techniques to Eastern Montana
6. Montana State University researchers map iron transport protein
7. Montana State University research reaches Supreme Court of India
8. Montana State researchers study spread of lake trout in Glacier National Park
9. Low exposure to asbestos-like mineral from Montana vermiculite may up lung disease risk
10. Antarcticas coldest, darkest season draws Montana State University researchers
11. Mongolian paleontologists with a dream come to Montana State University
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/14/2014)... in Cancer Research shows SIRT6—a protein known ... promote the development of skin cancers by turning on ... sun-damaged skin cells. , Previously considered protective, SIRT6 is ... that help regulate genomic stability and prevent some of ... DNA damage, which can lead to cancer. This study, ...
(Date:10/14/2014)... a new kind of stem cell that can become either ... vessels, according to a study published today in the journal ... cell type contradicts current theory on how organs arise from ... origins of, and future treatment for, liver cancer., Thanks to ... complex being made up of more than 200 cell types. ...
(Date:10/14/2014)... week, an international team of researchers, led by the ... the journal Nature Genetics a brief genomic ... varieties of the tomato plant. , The C.M. Rick ... important role in this study by providing seed of ... This study, which builds on the first tomato genome ...
Breaking Biology News(10 mins):Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg 2Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg 3
... the Center for Integrated Manufacturing Studies at Rochester Institute ... which blends 20 percent ethanol with gasoline, reduces the ... with traditional gasoline or E10 blends. In addition, the ... or maintenance in conventional internal combustion engines. The ...
... have identified some two million species, where can you ... that unites them all? A vastly improved database gives ... evolutionary relationships among living things. TreeBASE ... study evolutionary trees was first developed in the ...
... of a chemical family they hope will lead to ... specifically against a childhood tumor, according to research led ... chemical is the first small-molecule inhibitor to target the ... childhood eye tumor retinoblastoma as well as certain cases ...
Cached Biology News:E20 fuel reduces carbon monoxide and hydrocarbon emissions in automobiles 2Database gives access to the latest findings about the tree of life 2Database gives access to the latest findings about the tree of life 3Advances reported in quest for drugs targeting childhood cancer 2
(Date:10/20/2014)... , Oct. 20, 2014 Asterias Biotherapeutics, ... Company has signed a Notice of Grant Award ... (CIRM), effective October 1, 2014.  The NGA provides ... and the release of additional grant funds pursuant ... award for clinical development of Asterias, product, AST-OPC1. ...
(Date:10/20/2014)... PureTech , a science and technology development ... today the closing of a $55 million growth ... a $120 Billion group of funds. The funding ... forward and to advance new healthcare related products ... really go for the big ideas that can ...
(Date:10/19/2014)... 19, 2014 The Latin American hardware ... in Latin America with analysis and forecast of revenue. ... and is expected to reach $2,366.8 million by 2018, ... , Browse through the TOC of the Latin American ... the in-depth analysis provided. It also provides a glimpse ...
(Date:10/19/2014)... The Asian Automatic patient billing report defines and segments ... revenue. The Automatic patient billing market in Asia is ... at a developing CAGR of 7.2% from 2013 to ... Automatic patient billing market, to get an idea of ... of the segmentation of this market in the same ...
Breaking Biology Technology:Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 2PureTech Announces Expansion with Oversubscribed $55M Funding Round 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 5PureTech Announces Expansion with Oversubscribed $55M Funding Round 6The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3
... , Carsten-Peter Carstens Anna Waesche ,Stratagene , ... ,BL21-Gold cells * called the BL21-CodonPlus ... E. coli argU,ileY, and leuW tRNA genes. This modification ... to express in conventional E. coli,hosts due to the ...
... PCR mutagenesis kit produces a unique , mutational spectrum , ... , , ... Stratagene , , , ... The , GeneMorph PCR , mutagenesis kit ...
... precast gels* eliminate the need to manually pour gels, ... means no more gels,lost to bubbles or leaking.All CastAway ... 60 days from the date of manufacture, with no,detectable ... 32 Preformed Wells , Stratagene adds a new 6% ...
Cached Biology Technology:Codon Bias-Adjusted BL21 Derivatives for Protein Expression 2Codon Bias-Adjusted BL21 Derivatives for Protein Expression 3Codon Bias-Adjusted BL21 Derivatives for Protein Expression 4Codon Bias-Adjusted BL21 Derivatives for Protein Expression 5Codon Bias-Adjusted BL21 Derivatives for Protein Expression 6Codon Bias-Adjusted BL21 Derivatives for Protein Expression 7Randomize Gene Sequences with New PCR Mutagenesis Kit 2Randomize Gene Sequences with New PCR Mutagenesis Kit 3Randomize Gene Sequences with New PCR Mutagenesis Kit 4Randomize Gene Sequences with New PCR Mutagenesis Kit 5Randomize Gene Sequences with New PCR Mutagenesis Kit 6Randomize Gene Sequences with New PCR Mutagenesis Kit 7Randomize Gene Sequences with New PCR Mutagenesis Kit 8Randomize Gene Sequences with New PCR Mutagenesis Kit 9Randomize Gene Sequences with New PCR Mutagenesis Kit 10Randomize Gene Sequences with New PCR Mutagenesis Kit 11Four New CastAway Precast Gels 2
... Super-Sensitive, Super-Dark, Super-Small! ... with the ChemiDoc-It Imaging System. High-sensitivity ... produces low-background noise and wide dynamic ... a short exposure time. The light-tight ...
Mouse monoclonal [X223] to Lamin B1 + B2 - Nuclear Envelope Marker ( Abpromise for all tested applications). entrezGeneID: 4001 SwissProtID: P20700...
... Evidence Based Oligonucleotide) Genome Set and MEEBO ... Set contain a collection of open source ... exons, allowing interrogation of thousands of genes. ... Stanford University and UCSF, the sets enable ...
odz, odd Oz/ten-m homolog 1 [Source:RefSeq_peptide;Acc:NP_055068] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Biology Products: