Navigation Links
Monkey brains signal the desire to explore
Date:9/4/2009

DURHAM, N.C. Sticking with what you know often comes at the price of learning about more favorable alternatives.

Managing this trade-off is easy for many, but not for those with conditions such as Alzheimer's disease or obsessive-compulsive disorder who are trapped in simple routines.

Using brain scans in monkeys, Duke University Medical Center researchers are now able to predict when monkeys will switch from exploiting a known resource to exploring their options.

"Humans aren't the only animals who wonder if the grass is greener elsewhere, but it's hard to abandon what we know in hopes of finding something better," said John Pearson, Ph.D., research associate in the Duke Department of Neurobiology and lead author of a study published in this week's Current Biology.

"Studies like this one help reveal how the brain weighs costs and benefits in making that kind of decision," Pearson said. "We suspect that such a fundamental question engages many areas of the brain, but this is one of the first studies to show how individual neurons can carry signals for these kinds of strategic decisions."

The researchers looked at how nerve cells fired in a part of the brain known as the posterior cingulate cortex as the monkeys were offered a selection of rewards. Generally, these neurons fired more strongly when monkeys decided to explore new alternatives.

The monkeys started with four rewards to choose from, each a 200 microliter cup of juice. After that, the four targets began to slowly change in value, becoming larger or smaller. The monkeys were free to explore the other targets or stay with the initial target, whose value they knew for certain. Monkeys had to select an option to learn its current value and integrate this information with their knowledge of the chances of getting more juice at a different target.

By studying the individual neurons, the researchers could predict which strategy the monkey would employ.

"These data are interesting from a human health perspective, because the posterior cingulate cortex is the most metabolically active part of the brain when we are daydreaming or thinking to ourselves, and it is also one of the first parts of the brain to show damage in Alzheimer's disease," said Michael Platt, Ph.D., professor of neurobiology and evolutionary anthropology at Duke and senior author of the study.

"People with Alzheimer's become set in their ways and don't explore as much, which may be because this part of the brain is damaged," Platt said. "Likewise, in people with obsessive-compulsive disorder, they can become fixed on certain activities or patterns of activity and can't disengage from them, which may also relate to changes in this part of the brain that renders them mentally unable to switch gears between exploring and exploiting."

More research is needed to learn about how this part of the brain functions, which might be crucial to the flexible adaptation of strategy in response to changing environments, Pearson said.


'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Related biology news :

1. New monkey discovered in Brazil
2. Bolivian rainforest study suggests feeding behavior in monkeys and humans have ancient, shared roots
3. Beyond ooh-ooh, aah-aah-- expert on monkey communication kicks off Darwin series, May 5
4. Unexpected large monkey population discovered
5. Simian foamy virus found in several people living and working with monkeys in Asia
6. Newly discovered monkey is threatened with extinction
7. Not just for the monkeys: New publication shows evolution is everywhere
8. Ugandan monkeys harbor evidence of infection with unknown poxvirus
9. Moderate prenatal exposure to alcohol and stress in monkeys can cause touch sensitivity
10. Island monkeys do not recognize big cat calls
11. Monkey malaria widespread in humans and potentially fatal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market by ... Service, Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast to ... USD 14.30 Billion in 2017 to USD 31.75 Billion by 2022, at ... ... MarketsandMarkets Logo ...
(Date:4/6/2017)... -- Forecasts by Product Type (EAC), Biometrics, ... (Transportation & Logistics, Government & Public Sector, Utilities / ... Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality ... looking for a definitive report on the $27.9bn Access ... ...
(Date:4/3/2017)... , April 3, 2017  Data captured ... engineering platform, detected a statistically significant association ... prior to treatment and objective response of ... potential to predict whether cancer patients will ... treatment, as well as to improve both pre-infusion ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... USDM ... firm for the life sciences and healthcare industries, announces a presentation by Subbu ... , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will present a ...
(Date:10/9/2017)... ... October 09, 2017 , ... At its national board meeting in North ... in Harvard University’s Departments of Physics and Astronomy, has been selected for membership in ... winning team for the 2015 Breakthrough Prize in Fundamental physics for the discovery of ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first commercially available Hi-C kit. ... to perform Hi-C metagenome deconvolution using their own facilities, supplementing the company’s ...
(Date:10/5/2017)... ... , ... LabRoots , the leading provider of educational and interactive virtual ... to cancer research with a month-long promotion supporting the advancement of breast cancer research ... use promo code PinkRibbon to get 10 percent off their purchase of every the ...
Breaking Biology Technology: