Navigation Links
Monitoring outcomes of suicide attempts in pregnancy can better assess drug dangers

Los Angeles, London, New Delhi, Singapore and Washington DC (17 September, 2008) Monitoring the health of children born to women who attempted suicide while pregnant can shed light on which medicines and what doses are particularly dangerous to developing fetuses, according to researchers from Hungary who publish their findings in a series of reports in a special issue of Toxicology and Industrial Health, published this week by SAGE.

Information about the harm particular drugs can do to unborn children a measure known as tetrogenic potential is generally extrapolated from experimental animal investigations before the drug is approved for sale, because ethical considerations prevent regulated tests of safe doses being conducted in women who are pregnant.

However, because it is difficult to translate the findings from animal models to a real human situation, regulators err on the side of caution, and frequently prohibit the use of potentially beneficial agents in pregnant women.

"Many drugs are subject to contraindications or special warnings because their effects have not been sufficiently studied during pregnancy or non-clinical studies revealed adverse teratogenic or fetotoxic effects," explain the authors. "Data from self-poisoned pregnant women provide an appropriate source of information for use in better estimating the potential human risks of exposure to drugs during pregnancy."

In desiging their study, the Hungarian researchers reasoned that if no congenital abnormalities occur in children born to women who ingest very large doses of a drug during critical developmental periods, then this information supports the notion that the ingested drug is not a human teratogen. What is more, they report, self-poisoned women present the opportunity to gather data on dose-response relationships, which are difficult to ascertain from animal models, because they are hospitalised and undergo extensive pharmacological tests.

To test their hypothesis that self-poisoned pregnant women could give useful drug-safety data, the reserachers studied outcomes of all such admissions to the Department of Toxicological Internal Medicine, Kornyi Hospital, Budapest. During the study period of 1960-1993, 1044 pregnant women were admitted and 1021 of these attempted suicide with drugs (the other 23 pregnant women had accidental intoxication due to poisonous mushroom ingestion or carbon monoxide).

Among them, these women had 411 live-born infants, and 367 exposed children were evaluated with cognitive and behavioural tests as they grew up. The test results were compared with results for siblings whose gestational periods were normal. The researchers recorded occurances of congenital abnormalities, retardation in fetal growth (the most sensitive indicator of a fetotoxic effect of drugs), rates of preterm and low birthweight babies, and the deatials of the particular drug and dose taken by mothers.

Diazepam was one of the most frequently used drugs, with 229 pregnant women using it to attempt suicide. 112 women went on to deliver live babies, 15 of whom had congenital abnormalities. However, according to the researchers, when they further analysed the doses and timing of drug ingestion, they discovered that most of the congenital abnormalities could not be considered a teratogenic effect of diazepam because the time of suicide attempts did not overlap with the critical period for producing the defects.

"Although suicide attempts with large doses of diazepam would be expected to produce an extreme pathological condition in the embryos and fetuses, such was not observed," note the authors. "Thus congenital abnormalities in the offspring of pregnant women with psychiatric disorders are mainly associated with psychiatric disorders and related lifestyle (eg, multiple alcohol and substance abuse) or their interaction, but not by diazepam itself."

Although the authors acknowledge there are limitations to the method including the fact that pregnant women who attempt suicide are younger and with lower average socioeconomic status than the general population, and they tend to combine excess medications with large amounts of alcohol, tobacco, or other drugs they conclude that using the self-poisoning model for estimating human teratogenic risks of drugs is feasible and potentially beneficial.

They suggest that an international registry of self-poisoned pregnant women should be set up to enable more in-depth study of the effects of various doses of medication in pregnancy.


Contact: Mithu Mukherjee
SAGE Publications UK

Related biology news :

1. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
2. Mellon awards Carnegie Grant for Ecological Monitoring in South Africa
3. Woods Hole Research Center debuts new image mosaic that will strengthen global forest monitoring
4. Photo-monitoring whale sharks
5. Biomonitoring
6. New gas sensors for monitoring carbon dioxide sinks
7. Revolution in rain forest monitoring with MacArthur grant
8. UCLA researchers develop new PET scanning probe that will allowing monitoring of the immune system
9. More sensitive radiology monitoring in the Basque Country
10. Air monitoring helps anticipate possible ecosystem changes
11. Asthma monitoring on the Web
Post Your Comments:
(Date:11/16/2015)... 16, 2015  Synaptics Inc. (NASDAQ: SYNA ... today announced expansion of its TDDI product portfolio ... controller and display driver integration (TDDI) solutions designed ... new TDDI products add to the previously-announced ... (WQHD resolution), and TD4322 (FHD resolution) solutions. All ...
(Date:11/12/2015)... Mass. , Nov. 12, 2015  Arxspan ... Institute of MIT and Harvard for use of ... discovery information management tools. The partnership will support ... both biological and chemical research information internally and ... will be used for managing the Institute,s electronic ...
(Date:11/11/2015)... , Nov. 11, 2015   MedNet Solutions , an ... of clinical research, is pleased to announce that it will ... Trials (PCT) event, to be held November 17-19 in ... to view live demonstrations of iMedNet , ... how iMedNet has been able to deliver time ...
Breaking Biology News(10 mins):
(Date:11/30/2015)... , Nov. 30, 2015 Human Longevity, ... the company has acquired Cypher Genomics, Inc., a leading ... human genomic interpretation software solutions. The San ... join HLI including Cypher CEO and Co-founder, Ashley Van ... HLI,s Pediatric Business.  Financial details of the deal were ...
(Date:11/30/2015)...  Aytu BioScience, Inc. (OTCQB: AYTU), a commercial-stage specialty ... present at two upcoming investor conferences. Aytu is scheduled ... conference, to be held December 3, 2015, and at ... December 2 nd & 3 rd , 2015 ... live via webcast. Josh Disbrow , Chief ...
(Date:11/30/2015)... 2015  Northwest Biotherapeutics (NASDAQ: NWBO ) ("NW ... therapies for solid tumor cancers, announced today that the ... and the Company welcomes Neil Woodford,s call ... anonymous internet report on NW Bio.  The Company,s Board ... Powers stated, "We agree with Mr. Woodford that, ...
(Date:11/28/2015)... ... 28, 2015 , ... • Jeon Jin Bio Corp, a Korean Biotech venture ... , Bird Free, an oil-based, gel formula ... modalities including visual, smell, taste and touch, enabling safe, effective avian control without toxic ...
Breaking Biology Technology: