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Monitoring outcomes of suicide attempts in pregnancy can better assess drug dangers
Date:9/17/2008

Los Angeles, London, New Delhi, Singapore and Washington DC (17 September, 2008) Monitoring the health of children born to women who attempted suicide while pregnant can shed light on which medicines and what doses are particularly dangerous to developing fetuses, according to researchers from Hungary who publish their findings in a series of reports in a special issue of Toxicology and Industrial Health, published this week by SAGE.

Information about the harm particular drugs can do to unborn children a measure known as tetrogenic potential is generally extrapolated from experimental animal investigations before the drug is approved for sale, because ethical considerations prevent regulated tests of safe doses being conducted in women who are pregnant.

However, because it is difficult to translate the findings from animal models to a real human situation, regulators err on the side of caution, and frequently prohibit the use of potentially beneficial agents in pregnant women.

"Many drugs are subject to contraindications or special warnings because their effects have not been sufficiently studied during pregnancy or non-clinical studies revealed adverse teratogenic or fetotoxic effects," explain the authors. "Data from self-poisoned pregnant women provide an appropriate source of information for use in better estimating the potential human risks of exposure to drugs during pregnancy."

In desiging their study, the Hungarian researchers reasoned that if no congenital abnormalities occur in children born to women who ingest very large doses of a drug during critical developmental periods, then this information supports the notion that the ingested drug is not a human teratogen. What is more, they report, self-poisoned women present the opportunity to gather data on dose-response relationships, which are difficult to ascertain from animal models, because they are hospitalised and undergo extensive pharmacological tests. <
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Contact: Mithu Mukherjee
mithu.mukherjee@sagepub.co.uk
020-732-42223
SAGE Publications UK
Source:Eurekalert

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