Navigation Links
Monell scientists help identify a missing link in taste perception
Date:3/6/2013

Feinstein Institute for Medical Research, the knockout mice lack the gene that codes for CALHM1.

"Like humans, mice with an intact CALHM1 gene avidly drink sucrose and other sweeteners, and avoid bitter compounds such as quinine. However, mice lacking CALHM1 are very unusual," said Tordoff. "These mice treat sweeteners and bitter compounds as if they were water. They behave as if they can't taste them at all."

Responses to salty and sour tastes were not affected by the missing gene because perception of these taste qualities is mediated via a different set of taste cells.

In combination with electrophysiological data contributed by collaborators from other institutions, the findings demonstrate that pannexins and connexins, channel proteins previously thought to be involved in ATP release from taste cells, actually are not necessary for this to happen. "This paper provides compelling data to overturn the previous hypothesis," noted Matsumato. "It's part of what makes science so exciting."

Kevin Foskett, PhD, professor of Physiology at the Perelman School of Medicine, University of Pennsylvania, who with Marambaud is a senior author on the paper, recently identified CALHM1 as an ATP channel and speculated that that it might be involved in taste. "This is an example of a bona fide ATP ion channel with a clear physiological function," said Foskett. "Now we can connect the molecular dots of sweet and other tastes to the brain."

In addition to revealing CALHM1's critical role in sweet, bitter, and umami taste perception, the current work also lends insight into the channel's overall function in other tissues. Originally thought to control calcium levels inside cells, CALHM1 (calcium-homeostasis-modulator-1) may also contribute to ATP-mediated intercellular communication in the brain and elsewhere.


'/>"/>

Contact: Leslie Stein
stein@monell.org
267-519-4707
Monell Chemical Senses Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Mechanisms involved in resistance to the bacteria Salmonella studied in a Ph.D. thesis
2. Assessing a new technique for ensuring fresh produce remains Salmonella-free
3. Salmonella infection, but not as we know it
4. UCSB researchers discover particularly dangerous Salmonella
5. UCSB researchers find a way to detect stealthy, hypervirulent Salmonella strains
6. UCI-led study uncovers how Salmonella avoids the bodys immune response
7. UF scientists discover new crocodilian, hippo-like species from Panama
8. UT Southwestern scientists make mouse model of human cancer, demonstrate cure
9. Sea lamprey genome mapped with help from scientists at OU
10. Sequestration will be a devastating blow to the nations research institutions and scientists
11. Scientists explore topical health issues at meeting in Texas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/3/2014)... , Dec. 2, 2014   Marvin Test ... innovative test solutions for military, aerospace, and manufacturing ... of its successful TS-900 PXI semiconductor test ... features of high-end systems to customers at a ... compared to traditional ATE. "Our ...
(Date:11/21/2014)... NEW YORK , Nov. 19, 2014  Earlier ... Board at New York College, and one of the ... for biosensor signals that are transmitted from Smartphones to ... there were Smartphones and has one of the earliest ... are discussing its usage in the military, child care, ...
(Date:11/21/2014)... Calif. , Nov. 20, 2014   Atmel® ... leader in microcontroller (MCU) and touch technology solutions, today ... temperature sensors with the widest V cc ... higher temperature accuracy and faster I 2 C bus ... and serial EEPROM memory making them ideal for consumer, ...
Breaking Biology News(10 mins):Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4
... Increased summer precipitation apparently helping to spread spores of ... pines in northwestern British Columbia present strong evidence in ... to blame for the outbreak. The blight, caused by ... needles and, in the case of the British Columbia ...
... adult brain can reorganize neural pathways in response to ... and responses of neurons. But it has remained an ... In a new study published in the open-access journal ... continuous monitoring of neurons in the mouse adult visual ...
... the Fungal Research Trust have discovered millions of fungal ... , Aspergillus fumigatus, the species ... to cause disease; and the resulting condition Aspergillosis has ... and bone marrow transplant patients. Fungi also exacerbate asthma ...
Cached Biology News:A new window into structural plasticity in the adult visual cortex 2Pillows - a hot bed of fungal spores 2
(Date:12/19/2014)... 18, 2014  Decision Resources Group finds that the ... will grow moderately through 2023 as the aging population, ... of dental biomaterials all spur procedure volumes. Growth will ... China and India ... within reach for a larger proportion of the population. ...
(Date:12/19/2014)... 18, 2014   ISN has released its ... Indicators publication series. With data aggregated from ... in 2013 within its online contractor management platform, ISNetworld, ... performance indicator (KPI) statistics. The ... publication is available in two industry specific volumes: ...
(Date:12/17/2014)... New York, NY (PRWEB) December 16, 2014 ... undergone significant changes since 2013, which is why IBISWorld ... one, this industry continues to benefit from an intensified ... 2014, the proposal for new emission standards for power ... affected industry operators. According to IBISWorld Industry Analyst Sarah ...
(Date:12/17/2014)... Bellingham, Washington, USA (PRWEB) December 16, 2014 ... Kirstin Baum, manager at Philipps- Universität Marburg’s Department ... optics and photonics, in the newly released ... 2015-2016. “And never be too shy to ask ... STEM (science, technology, engineering, and mathematics) occupations ranging ...
Breaking Biology Technology:Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 3ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 2Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 3Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 3
... Halozyme Therapeutics, Inc. (Nasdaq: HALO ... targeting the extracellular matrix for the endocrinology, oncology, ... of $5.5 million from Baxter Healthcare Corporation representing ... terms of its HYLENEX licensing agreement, which provides ...
... ST. JOSEPH, Mich., Jan. 6 GeneGo, Inc., ... curated databases for systems biology,and pathway analysis ... has,renewed its MetaCore licenses for another three years. ... diseases and gynecological therapies,and GeneGo has good coverage ...
... 6 WuXi AppTec, the operating company of WuXi ... and development outsourcing company with operations in China and ... from ThalesNano Inc. for laboratory-based hydrogenation. WuXi joins ... have introduced and adopted the H-Cube technology. , ...
Cached Biology Technology:GeneGo Renews Its Agreement With Bayer Schering Pharma AG for Another Three Years 2WuXi AppTec Selects H-Cube from ThalesNano for Laboratory-based Hydrogenation 2
... purified chicken intestinal cytoplasmic 1,25-(OH)2D3 receptor ... (VDR) from human, rat, mouse, hamster, ... This antibody does not cross-react with ... detects both the occupied and unoccupied ...
... versatile power supply. Capable of producing up to ... is ideal for PAGE, SDS-PAGE, DNA or RNA ... small format transfer apparatus. It is designed to ... a continuously variable output in either mode. The ...
... is a highly compact, extremely reliable and easy ... and one hi-lo range switch control the output, ... 20 to 250 volts. One two-position switch toggles ... to output current. For maximum safety, the EC105 ...
... 177 amino acid polypeptide sequence corresponding to ... Produced by activation of a recombinant ... coli periplasm. SPECIFIC ACTIVITY:The specific activity ... mU/mg, where 1 U is the activity ...
Biology Products: