Navigation Links
Monell scientists help identify a missing link in taste perception
Date:3/6/2013

PHILADELPHIA (March 6, 2013) -- Working with a multidisciplinary consortium of 19 researchers from nine institutions, Monell scientists have provided critical information to identify CALHM1, a channel in the walls of taste receptor cells, as a necessary component in the process of sweet, bitter, and umami (savory) taste perception.

When sweet, bitter and umami molecules reach the tongue, they activate taste receptors in specialized cells called Type II taste cells. "The question that the consortium wanted to answer is, 'how do these taste cells tell the brain that they have detected something?' said Monell taste biologist Michael G. Tordoff, PhD. "This question has been a longstanding missing link in our understanding of taste perception."

The scientists already knew that activation of taste receptors on Type II cells initiates a complex chain of events inside the taste cells. What they found, as reported in the current issue of Nature, is that the final step involves the opening of a pore formed by CALHM1 in the taste cell membrane. The open channel allows molecules of the neurotransmitter ATP to leave the taste cell and relay a signal to adjacent nerve cells connected to the brain.

Monell molecular neurobiologist Ichiro Matsumato, PhD, contributed to the work by showing that the gene for CALHM1 is expressed in Type II taste cells, but not in other types of taste tissue. "Our findings demonstrate that the CALHM1 pore is localized specifically in cells that detect sweet, bitter and umami taste," said Matsumato.

The necessity of CALHM1 for the ability to taste sweet, bitter, and umami was demonstrated in behavioral tests performed by Tordoff. Reasoning that mice lacking the CALMH1 channel would not be able to release ATP to send information about sweet, bitter and umami taste detection to the brain, Tordoff tested the taste preferences of Calhm1 'knockout' mice. Engineered by co-author Philippe Marambaud, PhD, of the
'/>"/>

Contact: Leslie Stein
stein@monell.org
267-519-4707
Monell Chemical Senses Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Mechanisms involved in resistance to the bacteria Salmonella studied in a Ph.D. thesis
2. Assessing a new technique for ensuring fresh produce remains Salmonella-free
3. Salmonella infection, but not as we know it
4. UCSB researchers discover particularly dangerous Salmonella
5. UCSB researchers find a way to detect stealthy, hypervirulent Salmonella strains
6. UCI-led study uncovers how Salmonella avoids the bodys immune response
7. UF scientists discover new crocodilian, hippo-like species from Panama
8. UT Southwestern scientists make mouse model of human cancer, demonstrate cure
9. Sea lamprey genome mapped with help from scientists at OU
10. Sequestration will be a devastating blow to the nations research institutions and scientists
11. Scientists explore topical health issues at meeting in Texas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... CHARLOTTE, N.C. , Jan. 22, 2015 Infinisource has ... introduction of the G2 model. The G2 sets a higher ... company,s iSolved human capital management solution. With plug-and-play installation, touch ... G2 time clock provides a robust time collection solution for ...
(Date:12/22/2014)...  The 2014 Holiday Season may be the brightest ever ... that the long anticipated floodgates for consumer biometrics may ... smart phones, tablets, and wearable mobile devices that incorporate ... users with nearly 4.8 billion biometric devices by 2020.   ...
(Date:12/19/2014)... , Dec. 18, 2014   LaunchKey , the first ... post-password and Internet of Things era, today announced the ... venture round was led by Metamorphic Ventures with participation ... Partners, VegasTechFund, and others.  LaunchKey has raised $4 million ...
Breaking Biology News(10 mins):Infinisource's NXG series sets new time clock standard 2First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3
... Power ... Consumption, TUSTIN, ... high-performance module designed for connecting,devices that require low power consumption to ... applications that need,WLAN connectivity with minimal power usage, such as battery-operated,portable ...
... WASHINGTON -- A new NASA-led study shows human-caused climate ... of Earth,s natural systems, including permafrost thawing, plants blooming ... Africa. Cynthia Rosenzweig of NASA,s Goddard Institute ... 10 other institutions have linked physical and biological impacts ...
... May 13, 2008.-Unlike most scientific and technological advances, which ... often finds itself the center of public debate and ... by many of its applications. , In this ... (the first was in 2003), the sample has been ...
Cached Biology News:New Silex SX-560 Enables Enterprise 802.11 Wireless Connectivity for Battery Operated Devices 2NASA study links Earth impacts to human-caused climate change 2BBVA Foundation international study on attitudes to stem cell research 2BBVA Foundation international study on attitudes to stem cell research 3BBVA Foundation international study on attitudes to stem cell research 4BBVA Foundation international study on attitudes to stem cell research 5BBVA Foundation international study on attitudes to stem cell research 6
(Date:1/22/2015)... BOSTON , Jan. 22, 2015  Transwestern | RBJ today ... feet of office space for Shire a leading biopharmaceutical company, ... . Transwestern | RBJ,s Robert Richards , president, and ... the lease for the entire five-floor building at 95 Hayden ...
(Date:1/22/2015)... Johnston, RI (PRWEB) January 22, 2015 ... State , The growing team of brand-neutral, independent consultants, ... CIO Philip Rogers explained that over the years, his ... including , Moroso, Town of Plainfield, as well as ...
(Date:1/22/2015)... Controlled Substance Compliance Services (CSCS), a ... check the legal requirements around using controlled substances in ... , As their international operations expand and become increasingly ... built as a result of the first phase of ...
(Date:1/22/2015)... Medical Systems (NYSE: VAR ), world leader in ... to sustainability with inclusion on a prestigious list of the ... equipment company among the Corporate Knights Global 100 Most Sustainable ... Davos, Switzerland . "We ...
Breaking Biology Technology:Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2Global Compliance Service for Controlled Substances to Expand to China 2Varian Honored Among World's 100 Most Sustainable Corporations 2
... CHAPEL, Florida, March 20 NexGen,Biofuels Ltd. (OTC:NXGNF) ... its ordinary shares have been approved for quotation ... NexGen is a development stage company that is ... plants and blending assets in,the United States., ...
... increasing physician acceptance of electrophysiology ablation ... fibrillation, according to ... According to Millennium,Research Group,s Global Markets for Atrial Fibrillation ... were,performed for the treatment of AF in the US ...
... LUMEDX Corporation, a leading,provider of fully integrated ... version of its real-time patient and resource,scheduler ... physicians, staff, rooms with drag and drop ... and,substantial ROI., A free CardioSchedule Information ...
Cached Biology Technology:Electrophysiology Procedures for Atrial Fibrillation Treatment to Grow Over 25% Annually Over the Next Five Years 2LUMEDX Updates Real-Time Patient and Resource Scheduler for Healthcare Systems 2
For the quantitative determination of canine Interferon gamma,(IFN-γ) concentrations in cell culture supernates, serum and,plasma....
Request Info...
Homo sapiens olfactomedin 1, transcript variant 3...
Component of GELase™ Agarose Gel-Digesting Preparation. 1 ml of 50X Buffer is sufficient for replacing the buffer in at least 5 g of gel....
Biology Products: