Navigation Links
Monash scientists uncover a new understanding of male puberty
Date:3/14/2011

Scientists from Monash University have uncovered a new understanding of how male puberty begins.

The key to their findings lies with a protein known as SMAD3 and the rate at which it is produced. Researchers, Associate Professor Kate Loveland and Dr Catherine Itman from the Faculty of Medicine, Nursing and Health Sciences have discovered through laboratory testing that half as much SMAD3 protein results in faster maturation than the norm, and an inability to create SMAD3 results in abnormal responses to testosterone.

"SMAD3 is a protein that translates signals from the environment outside the cell to the nucleus, where it switches genes on or off," Dr Itman said. "We have been investigating how SMAD3 influences the growth of testis cells and their ability to respond to testosterone".

Puberty begins when the body starts to produce large amounts of the hormone testosterone. Early, or precocious, puberty involves the onset of puberty before eight years of age and affects around 1 in 10,000 boys. On the other hand, puberty is delayed when testis cells cannot respond normally to testosterone. Altered timing of puberty has implications in adulthood, with precocious puberty linked to reduced adult height and delayed puberty associated with reduced bone density.

Testosterone acts through specialized cells in the testis called Sertoli cells. Before puberty, Sertoli cells multiply, allowing the testis to grow. At puberty, Sertoli cells must stop growing so they can support sperm precursor cells to develop into sperm.

Professor Loveland, Dr Itman and their colleagues have been investigating how Sertoli cells switch from a multiplying state, making the testis big enough to make sperm, to a mature state that sustains sperm production.

"We have discovered that this is not an "on-off" switch. Rather, it is the amount of the SMAD3 protein in the Sertoli cell that is different in the immature, multiplyin
'/>"/>

Contact: Karen Sutherland
karen.sutherland@monash.edu
61-399-034-844
Monash University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Monash scientists debug superbug
2. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
3. Scientists identify novel inhibitor of human microRNA
4. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
5. MU scientists go green with gold, distribute environmentally friendly nanoparticles
6. Scientists identify gene that may contribute to improved rice yield
7. Scientists discover why a mothers high-fat diet contributes to obesity in her children
8. MU scientists see how HIV matures into an infection
9. Earth scientists keep an eye on Texas
10. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
11. Scientists identify a molecule that coordinates the movement of cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... , March 2, 2015 Synaptics Inc. ... of human interface solutions, today announced a new ... designed to enable rapid and secure transactions and ... for gaming is a turnkey solution providing mouse ... to quickly integrate fingerprint ID solutions into their ...
(Date:3/2/2015)... HUNTSVILLE, Ala. , March 2, 2015 /PRNewswire/ ... transaction processing. Data protection company Tharon Rankins Enterprises ... product that provides an ultra-safe way for businesses ... as their financial transactions. Beconux ... by Tharon Rankins Enterprises. Functioning similarly to an ...
(Date:3/2/2015)...   Neurotechnology , a provider of high-precision biometric, ... Software Development Kit (SDK). The SentiGaze algorithm enables ... webcams to track eye movements and generate heatmaps based ... can be used for applications such as analysis of ... SDK can also be used to develop interfaces for ...
Breaking Biology News(10 mins):Synaptics Unveils New Fingerprint ID Solution for Gamers 2Synaptics Unveils New Fingerprint ID Solution for Gamers 3Personal Data Protection Company Launches New Product 2Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 2Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 3
... Tri-Band WLAN Module in SDIO Card Form Factor, ... today,announced the SX-SDWAG, the first world,s first wireless ... form factor. Designed for,wireless local area network (WLAN) ... ideal for battery-operated portable devices in,the medical, weights ...
... consolidating world databases of ocean organisms have demoted ... culled from 34 regional and highly specialized inventories. ... ( www.marinespecies.org ) contains about 122,500 validated marine ... some 56,400 aliases 32% of all names ...
... Calif.) Michael Gazzaniga, professor of psychology at UC ... the Study of the Mind, has received the Humboldt ... "Professor Gazzaniga is a true pioneer in reaching ... the relationship between mind and brain," said UCSB Chancellor ...
Cached Biology News:Silex Introduces SX-SDWAG 802.11a/b/g SDIO Radio Card for OEM Portable Device Applications 2Census of Marine Life lists 122,500 known species, over halfway to complete inventory by Oct. 2010 2Census of Marine Life lists 122,500 known species, over halfway to complete inventory by Oct. 2010 3Census of Marine Life lists 122,500 known species, over halfway to complete inventory by Oct. 2010 4Census of Marine Life lists 122,500 known species, over halfway to complete inventory by Oct. 2010 5Neuroscientist Michael Gazzaniga awarded Humboldt Prize 2
(Date:3/2/2015)... 2015 Cutting-edge biotech & ... nutrition products reveal technological advancements are in growing ... as hyperglycemia, obesity, insulin level issues and other ... Companies in focus today are: RiceBran Technologies (NASDAQ: ... ANFI ), CEL-SCI Corporation (NYSE: ...
(Date:3/2/2015)... (PRWEB) March 02, 2015 Sterlitech is ... flat-sheet testing system at the 2015 AMTA Membrane Technology ... culmination of a decade’s worth of engineering and customer ... with a wide range of applications across an array ... enough to meet the dynamic needs of researchers and ...
(Date:2/28/2015)... Increasing its efforts to resolve the GMO Controversy ... of The GMO TRUTH podcast on both ITunes and at ... its mission to discover the truth and change the world. ... the truth about the GMOs in our food supply,” adds ... is an expansion of the documentary/investigative film-making methodology in place ...
(Date:2/27/2015)... , Feb. 27, 2015 A ... the NCATS rare-diseases portfolio " in Science ... new financing technique to reduce the risk associated ... and potentially unlock new levels of funding for ... product of a unique collaboration between scientists at ...
Breaking Biology Technology:Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 2Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 3Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 4Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 5Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 6Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 7Sterlitech Displays Complete CF042 Membrane Test System 2The Walk a Mile Project Launches “GMO Truth” Podcast 2New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 2New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 3New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 4
... Oct. 10 DermTech International, Inc.,a biotechnology ... early,detection of melanoma and other diseases, today ... Advisory Board. Dr. Quackenbush is a,Professor of ... Institute and Professor of Computational Biology and ...
... For Hispanic-Americans without health,insurance, it can be difficult ... prescription medicines. However, help is available for people,who ... doctors. Listen to this report from Pfizer ... Registered journalists can access video, audio, text, graphics ...
... MISSISSAUGA, ON, Oct. 9 /PRNewswire-FirstCall/ - Vasogen Inc.,(NASDAQ: VSGN ... the,third quarter of 2007. All dollar amounts referenced herein ... 31, 2007, our cash and cash equivalents and restricted ... 31, 2007. With,the repayment of our convertible notes during ...
Cached Biology Technology:DermTech Appoints BioStatistical Pioneer, John Quackenbush, Ph.D., as a Member of the Company's Scientific Advisory Board 2Vasogen Announces Third Quarter 2007 Results 2Vasogen Announces Third Quarter 2007 Results 3Vasogen Announces Third Quarter 2007 Results 4Vasogen Announces Third Quarter 2007 Results 5Vasogen Announces Third Quarter 2007 Results 6Vasogen Announces Third Quarter 2007 Results 7Vasogen Announces Third Quarter 2007 Results 8Vasogen Announces Third Quarter 2007 Results 9Vasogen Announces Third Quarter 2007 Results 10Vasogen Announces Third Quarter 2007 Results 11Vasogen Announces Third Quarter 2007 Results 12Vasogen Announces Third Quarter 2007 Results 13
This application changes sensitive keywords in an FCS file to remove patient information. It was contributed by Dr. David Miller....
... Killer Cell Receptor-P1, clone 1C10 ... Hybridoma produced by the ... mice immunized (BALB/c X C57BL/6)F1 ... and mouse myeloma cellline. ...
Phospho-SEK1/MKK4 (Thr261) Antibody...
Rabbit polyclonal to Warfarin ( Abpromise for all tested applications). Antigen: Chemical / Small Molecule conjugated to KLH...
Biology Products: