Navigation Links
Monash researchers uncover cancer survival secrets
Date:8/11/2008

A team of Monash University researchers has uncovered the role of a family of enzymes in the mutation of benign or less aggressive tumours into more aggressive, potentially fatal, cancers in the human body.

The discovery, published today in the international journal Cancer Cell, provides valuable insights into how cancer cells develop and mutate, and could ultimately change treatment options for sufferers around the world.

Team leader, Associate Professor Tony Tiganis, from the Department of Biochemistry and Molecular Biology at Monash University said their work showed that the enzymes known as protein tyrosine kinases (PTKs) had a greater role than previously thought in the rate of growth and tumour change over time.

"We already know that PTKs are associated with several types of aggressive cancers, including colon, breast and lung cancers," Associate Prof Tiganis said.

"What we have discovered is that PTKs have an important role to play as cancer cells grow and mutate to become potentially more aggressive tumours.

"The more we can learn about how tumours develop, the more we are able to prevent their growth in the future. There are already drugs that inhibit particular PTKs in the late stages of treatment. Our discovery could change the timing of when and how those or similar drugs are administered."

Assoc Professor Tiganis said all cells routinely divide and duplicate during growth. An entire genome is replicated and divides equally into two daughter cells. Sometimes things go wrong. To try to prevent this, nature has installed key cell surveillance checkpoints where molecular 'wardens' slow down DNA replication to try and correct mistakes to get the cell duplication back on track.

Normally, PTKs are turned off in the face of compromised DNA replication, but when PTK pathways remain on, unscheduled cell division can take place where cells distribute their DNA unevenly between the two resu
'/>"/>

Contact: Samantha Blair
samantha.blair@adm.monash.edu.au
039-903-4841
Monash University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Monash researcher receives prestigious Commonwealth Health Ministers award
2. USC researchers identify alternate pathway that leads to palate development
3. Researchers block damage to fetal brain following maternal alcohol consumption
4. In scientific first, Einstein researchers correct decline in organ function associated with old age
5. Researchers find cancer-inhibiting compound under the sea
6. UT Health Science Center researchers study diet and autism
7. UGA researchers win $9.2 million stem cell grant from NIH
8. Broad Institute researchers introduce next generation tool for visualizing genomic data
9. Spanish researchers discover significant leatherback turtle nesting beaches in the Caribbean
10. ORNL researchers analyze material with colossal ionic conductivity
11. UNH researchers tag first-ever free-swimming leatherback turtles in New England
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... first high-resolution map of the carbon stocks stored ... The new and improved methodology used to make ... market-based carbon economies. The new carbon map ... it provides the critical input to studies of ... and enforcement purposes. The technique includes the determination ...
(Date:7/29/2014)... Washington, USA The advanced optical methods and applications ... driving a revolution in the neurosciences were the inspiration ... by SPIE, the international society for optics and photonics. ... the BRAIN Initiative in the United States, and a ... for and provide examples of the impact that optics ...
(Date:7/29/2014)... the wrong food at a restaurant, don,t blame yourself; blame ... do with what you want and more to do with ... and the selections of over 300 diners, the Cornell study ... Management showed that when it comes to what you ... on the menu and how you imagine it will taste. ...
Breaking Biology News(10 mins):Peru's carbon quantified: Economic and conservation boon 2Peru's carbon quantified: Economic and conservation boon 3SPIE launches Neurophotonics journal with special section on BRAIN Initiative 2SPIE launches Neurophotonics journal with special section on BRAIN Initiative 3Menu secrets that can make you slim by design 2
... Scientists at Michigan State University have identified a ... could ultimately lead to plant varieties tailored specifically ... compartments in plant cells, convert sunlight, carbon dioxide ... the plant) during photosynthesis. The newly discovered protein, ...
... researchers are urging companies to embrace new methods for following ... much of the world,s global warming threats. , ... Because there is no universally accepted ... have sprung up on the Internet in the past few ...
... Institute of Technology have developed a novel way ... antiplaque toothpaste additives, antibiotics, nicotine, and even morphine, ... the research, now available online, will be featured ... of Nature Chemical Biology . Christina ...
Cached Biology News:MSU's discovery of plant protein holds promise for biofuel production 2Carnegie Mellon urges industry to broaden carbon footprint calculations 2Caltech engineers build mini drug-producing biofactories in yeast 2
(Date:7/30/2014)... 30, 2014 Vycom announces the addition ... designed to meet Factory Mutual (FM) 4910 fire propagation ... as wet benches, process tools, fume hoods, furniture and ... damage to semiconductor wafers used in electronic chip manufacturing. ... PVC solution with excellent workability and superior aesthetics. It ...
(Date:7/30/2014)... July 30, 2014 Researchers often use ... biology, but such devices can do much more ... As such, researchers have looked to patterned assemblies ... metabolic engineering to characterize – and potentially ... devices are envisioned to recreate animal and human ...
(Date:7/30/2014)... 30, 2014 NCERC at Southern ... present his findings on corn stover pretreatment methods ... week in Washington, D.C. , “Arun’s selection ... is a testament to the success of our ... “Thanks to the foresight and vision of SIUE ...
(Date:7/30/2014)... 2014 Immunology Summit-2014 ... Principle Investigators, scientists in the field, which includes ... at Case Western Reserve University School of Medicine, ... on “The effects of recombinant human IL-6 ... metalloproteinase-9”. Arya Biragyn, a Senior investigator at National ...
Breaking Biology Technology:Vycom Announces Flametec® Thermax PVC (FM4910 Listed) For a Variety of Clean Room Applications with Excellent Workability and Aesthetics 2UMD Researchers Bridge Gap between Microelectronics, Biological Systems 2UMD Researchers Bridge Gap between Microelectronics, Biological Systems 3UMD Researchers Bridge Gap between Microelectronics, Biological Systems 4NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 2NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 3Unveiling Breakthroughs in Clinical & Cellular Immunology 2Unveiling Breakthroughs in Clinical & Cellular Immunology 3
... PLEASANTON, Calif., April 20 Thoratec Corporation (Nasdaq: ... circulatory support therapies to save, support and restore failing ... (Pre-Market Approval) supplement with the FDA seeking to add ... the HeartMate II LVAS (left ventricular assist system). The ...
... Pharmaceuticals, Inc. (Nasdaq: ISIS ) announced today ... inhibition of novel targets that could offer new mechanisms ... Research (AACR) meeting. Research conducted by Isis and ... non-coding RNA, sigma RNA also known as Malat-1, that ...
... Advanced Instruments, Inc . ... the first true automation-friendly osmometer for the biopharmaceutical ... is specifically designed for -- and completely ... the biopharmaceutical laboratory," said Kelly Peterson, Product Manager, ...
Cached Biology Technology:Thoratec Announces Filing of PMA Seeking Destination Therapy Approval for HeartMate II(R) 2Thoratec Announces Filing of PMA Seeking Destination Therapy Approval for HeartMate II(R) 3Thoratec Announces Filing of PMA Seeking Destination Therapy Approval for HeartMate II(R) 4Isis and Partners Present New Research at the American Association for Cancer Research 2009 Annual Meeting 2Isis and Partners Present New Research at the American Association for Cancer Research 2009 Annual Meeting 3Advanced Instruments Introduces 2020-BIO Multi-Sample Osmometer as First True Automation-Friendly Osmometer for the Biopharmaceutical Industry 2Advanced Instruments Introduces 2020-BIO Multi-Sample Osmometer as First True Automation-Friendly Osmometer for the Biopharmaceutical Industry 3
...
Lyophilized. Purity: ≥90% by electrophoresis. Reconstitute in 0.3% NaCl. Prepared from serum that has been shown by certified tests to be negative for HBsAg and for HIV and HCV antibodies. ...
Porcine Pulmonary Artery Endothelial Cells (PPAEC) (>500,000 cells)...
PP2B-Abeta (C-20)...
Biology Products: