Navigation Links
Monash researchers uncover cancer survival secrets
Date:8/11/2008

A team of Monash University researchers has uncovered the role of a family of enzymes in the mutation of benign or less aggressive tumours into more aggressive, potentially fatal, cancers in the human body.

The discovery, published today in the international journal Cancer Cell, provides valuable insights into how cancer cells develop and mutate, and could ultimately change treatment options for sufferers around the world.

Team leader, Associate Professor Tony Tiganis, from the Department of Biochemistry and Molecular Biology at Monash University said their work showed that the enzymes known as protein tyrosine kinases (PTKs) had a greater role than previously thought in the rate of growth and tumour change over time.

"We already know that PTKs are associated with several types of aggressive cancers, including colon, breast and lung cancers," Associate Prof Tiganis said.

"What we have discovered is that PTKs have an important role to play as cancer cells grow and mutate to become potentially more aggressive tumours.

"The more we can learn about how tumours develop, the more we are able to prevent their growth in the future. There are already drugs that inhibit particular PTKs in the late stages of treatment. Our discovery could change the timing of when and how those or similar drugs are administered."

Assoc Professor Tiganis said all cells routinely divide and duplicate during growth. An entire genome is replicated and divides equally into two daughter cells. Sometimes things go wrong. To try to prevent this, nature has installed key cell surveillance checkpoints where molecular 'wardens' slow down DNA replication to try and correct mistakes to get the cell duplication back on track.

Normally, PTKs are turned off in the face of compromised DNA replication, but when PTK pathways remain on, unscheduled cell division can take place where cells distribute their DNA unevenly between the two resulting daughter cells. As a result, tumour cells can accumulate or lose genes and chromosomes, and gain a growth and survival advantage.

"Our studies have shown that PTK pathways are intimately associated with the regulation of checkpoint responses during DNA replication," Assoc Prof Tiganis said.

"We have identified one mechanism by which PTKs may remain activated and allow cancer cells to bypass the molecular warden of DNA replication. They may lack a key enzyme called TCPTP." Experiments published in the prestigious journal Cancer Cell have been conducted using cells grown in the laboratory. "But the big question remains. What happens in the real world of human cancers?"

The Monash team will now apply their laboratory findings to human cancer samples to see if they contain low levels of TCPTP and hopefully cement the role of this protein in cancer formation and development.


'/>"/>

Contact: Samantha Blair
samantha.blair@adm.monash.edu.au
039-903-4841
Monash University
Source:Eurekalert

Related biology news :

1. Monash researcher receives prestigious Commonwealth Health Ministers award
2. USC researchers identify alternate pathway that leads to palate development
3. Researchers block damage to fetal brain following maternal alcohol consumption
4. In scientific first, Einstein researchers correct decline in organ function associated with old age
5. Researchers find cancer-inhibiting compound under the sea
6. UT Health Science Center researchers study diet and autism
7. UGA researchers win $9.2 million stem cell grant from NIH
8. Broad Institute researchers introduce next generation tool for visualizing genomic data
9. Spanish researchers discover significant leatherback turtle nesting beaches in the Caribbean
10. ORNL researchers analyze material with colossal ionic conductivity
11. UNH researchers tag first-ever free-swimming leatherback turtles in New England
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2017)... -- RAM Group , Singaporean based technology ... biometric authentication based on a novel  quantum-state ... perform biometric authentication. These new sensors are based on a ... Group and its partners. This sensor will have widespread ... security. Ram Group is a next generation sensor ...
(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. (NASDAQ: ... announces the filing of its 2016 Annual Report on Form 10-K ... Commission. ... 10-K is available in the Investor Relations section of the Company,s ... the SEC,s website at http://www.sec.gov . 2016 Year ...
(Date:4/11/2017)... , Apr. 11, 2017 Research and ... Market 2017-2021" report to their offering. ... The global eye tracking market to grow at a ... report, Global Eye Tracking Market 2017-2021, has been prepared based on ... covers the market landscape and its growth prospects over the coming ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... ... July 20, 2017 , ... Corista, a ... and artificial intelligence Tuesday, July 25, during the Association of Pathology Chairs’ Jubilee ... Medicine. , Baras, Associate Director of Pathology Informatics, will present “The Digital ...
(Date:7/18/2017)... ... July 18, 2017 , ... Sourcing custom glass or quartz parts can ... the capabilities to properly execute your job can take many hours of emails, phone ... sourcing portal designed to showcase the company’s capabilities and core custom categories, and enables ...
(Date:7/18/2017)... Fairfield, NJ (PRWEB) , ... July 18, 2017 ... ... in corporate finance technology, DataForm Software ( https://dataformsoftware.com ) announces the migration of ... – to Microsoft Azure. Planet is a team-centric, enterprise work management system that ...
(Date:7/17/2017)... ... July 17, 2017 , ... ... a wide range of overlapping clinical features. The advancement of targeted next-generation sequencing ... of NDD research and testing. , However, designing a custom panel for ...
Breaking Biology Technology: