Navigation Links
Moms who eat high-fat diet before, during pregnancy 'program' babies to be fat, at risk

PORTLAND, Ore. New research in mice indicates that babies born to moms who eat a high-fat diet before and during pregnancy have a higher fat mass and smaller livers than babies whose moms consume low-fat fare, according to scientists at Oregon Health & Science University Doernbecher Children's Hospital.

The good news, the researchers report, is that moms who switch to a low-fat diet during pregnancy considerably reduce the risk of these negative effects. Their findings are published online in the American Journal of Physiology and Endocrinology Metabolism, a publication of the American Physiological Society.

Previous research has shown babies who receive too much or too little nutrition in the womb experience profound and permanent changes in their development including alterations in the structure of the liver, brain and pancreas that increase their susceptibility to developing various diseases later in life, including obesity, diabetes and cardiovascular disease.

And given that nearly half of women of childbearing age are overweight or obese in the United States, according to the Centers for Disease Control and Prevention, there is a pressing need to inform women and their health care providers of the inherent dangers maternal overeating poses to their child's future health and risk of chronic disease.

"One of the key findings here is that the offspring are born with a marked shift in body composition, away from lean mass and toward fat mass, prior to any dietary exposure in the offspring themselves," said principal investigator Stephanie M. Krasnow, Ph.D., a scientist in the Pap Family Pediatric Research Institute at OHSU Doernbecher Children's Hospital.

Krasnow and colleagues in the Daniel Marks Lab used a mouse model to examine how consumption of a high-fat diet during pregnancy effects body composition in the newborn. Female mice were fed either a low-fat or high-fat diet for six months and were mated with male mice after 4, 12 and 23 weeks. The females who ate a high-fat diet gained more body weight and had a higher fat mass than the females who ate a low-fat diet. And on the day of birth, babies born to females who had consumed a high-fat food had more body fat, less lean mass, and smaller livers than the newborns of females that consumed low-fat food.

These changes in body composition and organ size occurred before the female mice eating a high-fat diet became obese, the researchers report. And even when the females were not obese, eating a high-fat diet prior to and during pregnancy "programmed" their unborn babies to have increased body fat and smaller livers at birth. Fortunately, the researchers found, switching to a low-fat diet just during pregnancy prevented the infants from accumulating excess fat mass in utero and also prevented their having smaller livers.

"These findings demonstrate that changing to a low-fat diet during pregnancy minimizes the harmful effects of maternal obesity on the newborn's body composition, potentially reducing the child's risk of developing obesity and related diseases later in life," said Krasnow.


Contact: Tamara Hargens-Bradley
Oregon Health & Science University

Related biology news :

1. Scientists discover why a mothers high-fat diet contributes to obesity in her children
2. High-fat diets inflame fat tissue around blood vessels, contribute to heart disease
3. Researchers uncover obesity gene involved in weight gain response to high-fat diet
4. High-fat diet affects physical and memory abilities of rats after 9 days
5. Do high-fat diets make us stupid and lazy?
6. TV bombards children with commercials for high-fat and high-sugar foods
7. Flavonoids in orange juice suppress oxidative stress from high-fat, high-carb meal
8. High-fat diet during puberty linked to breast cancer risk later in life
9. UNC study helps clarify link between high-fat diet and type 2 diabetes
10. Study reveals how high-fat diet during pregnancy increases risk of stillbirth
11. Antioxidant spices reduce negative effects of high-fat meal
Post Your Comments:
(Date:10/12/2015)... , Oct. 9, 2015 Research and Markets ... Research, Inc,s new report "Biometrics: Market Shares, Strategies, ... --> --> The ... the Biometrics market segment. Research represents a selection from ... and cogent market materials, with selections made by the ...
(Date:10/12/2015)... -- Research and Markets ( ) has ... Market by Component (Hardware & Software), Product (Scanner ... (Travel & Immigration, Military & Defense, & Others) ... report to their offering. ... worth 3627.90 Million USD by 2020 ...
(Date:10/8/2015)... Oktober 2015 Die Track Group, ... des Bereiches Tracking, hat heute bekannt gegeben, ... Virginias (Department of Corrections – DOC) unterzeichnet ... alle Strafen geliefert werden, die der Behörde ... für den Amerikanischen Kontinent der Track Group. ...
Breaking Biology News(10 mins):
(Date:10/12/2015)... , Oct. 12, 2015  Patara Pharma, ... allergic and inflammatory diseases and conditions, today announced ... preferred stock financing. Concurrent with the close of ... into a Loan and Security Agreement with Silicon ... to $7 million. Patara will use the funds ...
(Date:10/12/2015)... NAMUR , Belgium , Oct. 12, ... today announced that full results from a completed clinical study ... pancreatic cancers have been published in the online issue of ... Epigenetics Society. The peer-reviewed study was conducted in collaboration with ... , and led by Roland Andersson , MD, PhD, ...
(Date:10/12/2015)... ... 2015 , ... LifeTrak , a leader in consumer fitness, heart rate ... amphibious fitness tracker that seeks to meet the needs of multi-sport athletes. Zoom is ... monitoring both in water and on land, making it the only fitness tracker ...
(Date:10/10/2015)... ANNAPOLIS, Maryland , 10. Oktober, 2015 /PRNewswire/ ... O. Matsui (Abgeordnete der Demokratischen Partei für Kalifornien) ... 11. bis 17. Oktober) in die Aufzeichnungen des ... Plasma Protein Therapeutics Association (PPTA) und ... , Hebung des Bewusstseins über Plasmaspenden ...
Breaking Biology Technology: