Mom's obesity during conception phase may set the stage for offspring's ob...(e existing body of evidence showing that...)

Date:1/3/2008

e existing body of evidence showing that both maternal obesity and genetic background influence offspring's susceptibility to obesity. It goes further, to highlight the role of post-natal obesegenic diet as a determinant in revealing subtle programming imposed by maternal obesity. The results also demonstrate that high levels of adiposity (body fat) occur in the offspring of obese mothers despite consuming similar calories as their lean-offspring counterparts and that offspring obesity is associated with insulin resistance.

The "programming" of susceptibility to obesity occurs in the absence of changes in birth weights and other fetal outcomes.

According to Dr. Kartik Shankar of the Arkansas Children's Nutrition Center, "The mother's body composition at conception has important implications for the metabolism and risk of obesity in the offspring in later years. Not only do these findings help us appreciate the reasons for the rapid rise in obesity, this novel model will allow us to understand the underlying mechanisms and should provide fertile opportunity for translational type research."

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Contact: Donna Krupa DKrupa@The-APS.org 301-634-7209 American Physiological Society Source:Eurekalert

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