Navigation Links
Molecules in the spotlight

This release is available in French.

A novel x-ray technique allowing the observation of molecular motion on a time scale never reached before has been developed by a team of researchers from EPFL and the Paul Scherrer Institute (PSI) in Switzerland. Results of the research led by Professor Majed Chergui, head of EPFL's laboratory of Ultrafast Spectroscopy in collaboration with the FEMTO group at PSI appear online December 11 in the journal Science.

This discovery opens promising prospects for the study of chemical and biological systems. It allows a better understanding of the structural evolution of molecules during a chemical reaction. The researchers have applied it to the study of metal-based molecular complexes, of high interest in chemistry. This could lead to applications in magnetic data storage or solar energy. It also opens new perspectives in biology, because the molecules studied are analogous to the active center in hemoproteins (haemoglobin, myoglobin).

Structural evolution

It is possible to follow a cat landing on its feel in "real time" using a camera with shutter times on the order of tens of milliseconds. To do the same with molecules, 100 000 million times smaller than cats, requires shutter times that are 100 000 million times faster -- a few tens of femtoseconds (1 femtosecond is to a second what a second is to 32 million years).

Although there are lasers that permit such shutter speeds, no existing optical methods can capture the molecular structure. In order to overcome this limitation, Chergui's team combined lasers delivering femtosecond pulses of ultraviolet-visible light with a source of femtosecond X-ray pulses, in a technique now known as ultrafast X-Ray Absorption Spectroscopy. "With the extremely short wavelengths of this kind of pulsed radiation, it is possible to observe the molecular structure changes, and thus to obtain precise information about the breaking, the formation, or the transformation of chemical bonds between atoms. And all this, in real time," explains Chergui.

Collaboration with the Paul Scherrer Institute

To reach this degree of precision, the researchers needed a source of stable and tunable femtosecond X-Ray pulses. They found it at the Paul Scherrer Institute in Villigen, Switzerland, in a collaboration with Dr. Rafael Abela's team. Using the femtosecond X-ray pulses extracted from the Swiss Light Source synchrotron in a technique developed at the PSI, the researchers were able to follow in real time a structural change of the molecule in 150 femtoseconds. This method is an excellent tool for analysing reactions in liquid and disordered environments that characterize many biological and chemical systems.


Contact: Majed Chergui
Ecole Polytechnique Fdrale de Lausanne

Related biology news :

1. Argonne scientists discover possible mechanism for creating handedness in biological molecules
2. Linking Proteins, Wires, Dots, and Molecules into Useful Devices
3. Bare bones of crystal growth: Biomolecules enhance metal contents in calcite
4. RNA molecules, delivery system improve vaccine responses, effectiveness
5. Improving our ability to peek inside molecules
6. Do 68 molecules hold the key to understanding disease?
7. Synthetic molecules emulate enzyme behavior for the first time
8. Nanoglassblowing seen as boon to study of individual molecules
9. Researchers observe spontaneous ratcheting of single ribosome molecules
10. Argonne scientists use lasers to align molecules
11. Two suppressor molecules affect 70 genes in leukemia
Post Your Comments:
(Date:10/29/2015)... Oct. 29, 2015 Daon, a global leader ... has released a new version of its IdentityX ... North America have already installed IdentityX ... includes a FIDO UAF certified server component ... to activate FIDO features. These customers include some of ...
(Date:10/27/2015)... 2015 In the present market scenario, security ... various industry verticals such as banking, healthcare, defense, electronic ... demand for secure & simplified access control and growing ... hacking of bank accounts, misuse of users, , and ... PC,s, laptops, and smartphones are expected to provide potential ...
(Date:10/26/2015)... 2015  Delta ID Inc., a company focused on ... PC devices, announced its ActiveIRIS® technology powers the iris ... launched by NTT DOCOMO, INC in Japan ... smartphone to include iris recognition technology, after a very ... in May 2015, world,s first smartphone to have this ...
Breaking Biology News(10 mins):
(Date:11/30/2015)... , Nov. 30, 2015  Culprits beware, a ... chemistry professor Jan Halámek, is taking crime scene ...   -->   ... --> --> ... have discovered a straightforward concept for identifying whether ...
(Date:11/30/2015)... , Nov. 30, 2015 /PRNewswire/ - Zenith Epigenetics Corp. ("Zenith" ... Norman C.W. Wong to its Board of Directors ... to Zenith with a wealth of experience as co-founder of ... biology. --> --> Dr. ... Epigenetics, board of directors. Zenith,s long standing expertise in epigenetics ...
(Date:11/30/2015)... ... November 30, 2015 , ... Imagine Exhibitions and Universal ... Exhibition, opening in March 2016 at Melbourne Museum in Melbourne, Australia. Immediately following ... North American tour dates. The Exhibition is based on Universal Pictures’ Jurassic World, ...
(Date:11/30/2015)... Human Longevity, Inc. (HLI), the genomics-based, technology-driven ... Genomics, Inc., a leading genome informatics company offering highly ... The San Diego -based company has ... and Co-founder, Ashley Van Zeeland , Ph.D., who is ... of the deal were not disclosed. ...
Breaking Biology Technology: