Navigation Links
Molecules delivering drugs as they walk
Date:8/3/2010

An octopus-like polymer can "walk" along the wall of a narrow channel as it is pushed through by a solvent. Now research in The Journal of Chemical Physics, which is published by the American Institute of Physics, provides a theoretical model that compares the transport characteristics of straight- and branched-chain polymers in smooth channels as well as in channels whose walls interact with the polymer -- work that could aid in the development of carrier molecules for delivering drugs at a controlled rate in the body.

"The deformability of particles makes them very different from atoms or hard colloids," says author Arash Nikoubashman of Heinrich Heine University of Dsseldorf, Germany. "Equilibrium studies show a huge impact on the self-organization of these molecules and we wanted to know how this aspect expresses itself when the molecules are pushed around by a flowing solvent."

The researchers compared the flow of linear polymers to that of dendrimers, or regularly branched polymers. Results indicate that flow through a narrow channel is independent of the number of monomers in the polymer chain. In a smooth channel, flow is also independent of shape: the linear polymer and the dendrimer both travel in the rapid solvent flow toward the center of the channel. When patches that attract the polymer are placed on the wall, however, the dendrimer "walks" along the wall from patch to patch, while the linear polymer tends to remain close to the wall, moving very slowly, if at all, through the channel.

Possible applications of this research include an understanding to the movement of biological molecules through pores, and the development of dendritic carriers to deliver molecules at a controlled rate. Blood vessels resemble the model channel with patches of differing chemical affinities.

"At the moment we are investigating the cargo transport capabilities of dendrimers," says Nikoubashman. "Place a guest molecule, such
'/>"/>

Contact: Jason Socrates Bardi
jbardi@aip.org
301-209-3091
American Institute of Physics
Source:Eurekalert

Page: 1 2

Related biology news :

1. Nanoblasts from laser-activated nanoparticles move molecules, proteins and DNA into cells
2. Correcting a trick of the light brings molecules into view
3. Molecules typically found in blue jean and ink dyes may lead to more efficient solar cells
4. Stretching molecules yields new understanding of electricity
5. Scripps Research scientists break barrier to creating potential therapeutic molecules
6. New method for producing libraries of important carbohydrate molecules
7. Intracellular express -- why transport protein molecules have brakes
8. Light activated warhead turns modest molecules into super protein killers
9. New sensor array detects single molecules for the first time
10. New cancer-fighting strategy focuses on signaling molecules
11. When molecules leave tire tracks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... julio de 2015 BGI llevará a cabo la ... 22 al 25 de octubre de 2015, en ... celebra su décimo aniversario este año. Desde su inauguración ... las reuniones anuales más influyentes del mundo en los ... conferencias científicas más dinámicas, entusiastas y amenas. ...
(Date:7/31/2015)... -- Die 10. internationale Konferenz zu Genomik (ICG-10, ... findet vom 22. bis 25. Oktober 2015 in ... Die Konferenz feiert in diesem Jahr ... die ICG weltweit zu einem der einflussreichsten jährlichen ... der dynamischsten, enthusiastischsten und angenehmsten wissenschaftlichen Zusammentreffen. ...
(Date:7/27/2015)... 2015  Synaptics Inc. (NASDAQ: SYNA ), ... announced that Huawei has selected the Synaptics ® ... stylish smartwatch. Huawei chose the state-of-the-art ClearPad capacitive ... and highly responsive human interface qualities such as ... required a classic round watch face and Synaptics ...
Breaking Biology News(10 mins):La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 3Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3
... the human mind in the hope of answering some ... to the nature of knowledge. Today cognitive scientists link ... research in various areas, an approach epitomized by WIREs ... The content of this journal will be free for ...
... Iowa - Research at Iowa State University has led scientists ... and eventually kills them. A research team led by Gaya ... had previously solved the structure of a critical part of ... host immune suppression. Amarasinghe and his research team now know ...
... GAINESVILLE, Fla. The University of Florida,s Institute on ... National Institutes of Health to construct an almost 40,000-square-foot ... building will bring together scientists from a range of ... out on the campus. "This is a unique ...
Cached Biology News:Iowa State University researcher discovers Ebola's deadly secret 2UF gets almost $15 million in federal funds to build research complex to help older adults 2UF gets almost $15 million in federal funds to build research complex to help older adults 3
(Date:8/3/2015)... 2015  Aethlon Medical, Inc. (Nasdaq: AEMD ), ... life-threatening diseases, today announced that it will host its ... on Thursday, August 13, 2015 at 4:30 p.m. Eastern ... the release of fiscal 2016 first quarter results.  A ... two hours after the call at the Investor Relations ...
(Date:8/3/2015)... , August 3, 2015 ... Study on 3D Cell Culture: Asia ... Persistence Market Research, the global 3D cell culture market was valued ... to expand at a CAGR of 29.1% to account ... Full Report with TOC:  http://www.persistencemarketresearch.com/market-research/3d-cell-cultures-market.asp 3D ...
(Date:7/31/2015)... , July 31, 2015 In today,s ... that help them drive positive health outcomes, improve ... source of patient care in their communities. At ... tradeshow and conference, AmerisourceBergen announced a new set ... Services Administration Organization and help independent pharmacies endure ...
(Date:7/31/2015)... ... July 31, 2015 , ... ... and quantification of partially hydrolyzed gluten in foods, has been accepted by AOAC ... method “Partially Hydrolyzed Gluten in Fermented Cereal-Based Products by R5 Competitive ELISA,” based ...
Breaking Biology Technology:Aethlon Medical To Host First Quarter Fiscal 2016 Investor Call on August 13, 2015 2Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 2Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 3Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 4AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 2AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 3RIDASCREEN® Competitve Gliadin Receives AOAC Official First Action Status 2
... alarming pace, a University of Central Florida research team is ... a miniature diagnostic toolkit in the hopes of stimulating earlier ... the National Science Foundation for up to $600,000 over three ... of a credit card to detect damaging levels of oxygen ...
... Protection Agency today outlined a new research strategy ... human health and the environment. Nanomaterials are materials ... A nanometer is approximately 1/100,000 the width of ... in hundreds of consumer products, including sunscreen, cosmetics ...
... ... new ClearTrial TRACK provides integrated planning, outsourcing, project tracking, reforecasting, accrual management, and ... ... www.cleartrial.com ), the leading provider of Clinical Trial Operations (CTO) software, announced today ...
Cached Biology Technology:UCF team developing tool kit to help diagnose dementia 2EPA announces research strategy to study nanomaterials 2ClearTrial Launches Industry-first Software Platform for Integrating Clinical Trial Operations from Plan to Cash™, Driving Operational Efficiencies and Accelerating Clinical Development 2ClearTrial Launches Industry-first Software Platform for Integrating Clinical Trial Operations from Plan to Cash™, Driving Operational Efficiencies and Accelerating Clinical Development 3ClearTrial Launches Industry-first Software Platform for Integrating Clinical Trial Operations from Plan to Cash™, Driving Operational Efficiencies and Accelerating Clinical Development 4
...
Mouse monoclonal [2Q2147] to Aequorin ( Abpromise for all tested applications)....
Phosphotyrosine IgG mouse monoclonal antibody: Alkaline Phosphatase conjugate...
... mixed TAMRA isomers are predominantly used for ... preferred for labeling peptides and nucleotides because ... that is often required in the conjugation ... 6-TAMRA for labeling peptides and proteins. 6-TAMRA ...
Biology Products: