Navigation Links
Molecules delivering drugs as they walk
Date:8/3/2010

An octopus-like polymer can "walk" along the wall of a narrow channel as it is pushed through by a solvent. Now research in The Journal of Chemical Physics, which is published by the American Institute of Physics, provides a theoretical model that compares the transport characteristics of straight- and branched-chain polymers in smooth channels as well as in channels whose walls interact with the polymer -- work that could aid in the development of carrier molecules for delivering drugs at a controlled rate in the body.

"The deformability of particles makes them very different from atoms or hard colloids," says author Arash Nikoubashman of Heinrich Heine University of Dsseldorf, Germany. "Equilibrium studies show a huge impact on the self-organization of these molecules and we wanted to know how this aspect expresses itself when the molecules are pushed around by a flowing solvent."

The researchers compared the flow of linear polymers to that of dendrimers, or regularly branched polymers. Results indicate that flow through a narrow channel is independent of the number of monomers in the polymer chain. In a smooth channel, flow is also independent of shape: the linear polymer and the dendrimer both travel in the rapid solvent flow toward the center of the channel. When patches that attract the polymer are placed on the wall, however, the dendrimer "walks" along the wall from patch to patch, while the linear polymer tends to remain close to the wall, moving very slowly, if at all, through the channel.

Possible applications of this research include an understanding to the movement of biological molecules through pores, and the development of dendritic carriers to deliver molecules at a controlled rate. Blood vessels resemble the model channel with patches of differing chemical affinities.

"At the moment we are investigating the cargo transport capabilities of dendrimers," says Nikoubashman. "Place a guest molecule, such as a drug within a dendrimer that has affinity to specific patches on the vessel wall and let it flow with the solvent." As the dendrimer docks on the patches, it may be possible to deliver the cargo to the dock while the carrier washes away with the flow.


'/>"/>

Contact: Jason Socrates Bardi
jbardi@aip.org
301-209-3091
American Institute of Physics
Source:Eurekalert

Related biology news :

1. Nanoblasts from laser-activated nanoparticles move molecules, proteins and DNA into cells
2. Correcting a trick of the light brings molecules into view
3. Molecules typically found in blue jean and ink dyes may lead to more efficient solar cells
4. Stretching molecules yields new understanding of electricity
5. Scripps Research scientists break barrier to creating potential therapeutic molecules
6. New method for producing libraries of important carbohydrate molecules
7. Intracellular express -- why transport protein molecules have brakes
8. Light activated warhead turns modest molecules into super protein killers
9. New sensor array detects single molecules for the first time
10. New cancer-fighting strategy focuses on signaling molecules
11. When molecules leave tire tracks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... , March 28, 2017 ... Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video ... and Region - Global Forecast to 2022", published by ... in 2016 and is projected to reach USD 75.64 ... 2017 and 2022. The base year considered for the ...
(Date:3/23/2017)... , Mar. 23, 2017 Research and ... System Market Analysis & Trends - Industry Forecast to 2025" ... ... grow at a CAGR of around 8.8% over the next decade ... industry report analyzes the market estimates and forecasts for all the ...
(Date:3/20/2017)... 2017 PMD Healthcare announces the release of ... Management System (WMS), a remote, real-time lung health monitoring ... Healthcare is a Medical Device, Digital Health, and Chronic ... creating innovative solutions that empower people to improve their ... PMD developed the first ever personal spirometer, Spiro PD, ...
Breaking Biology News(10 mins):
(Date:4/25/2017)... ... April 25, 2017 , ... ... Medicine & Rehabilitation, P.A. , proudly announced today that acclaimed physiatrist Matthew Terzella, ... duties on May 15, 2017. , Dr. Terzella completed his residency in Physical ...
(Date:4/21/2017)... (PRWEB) , ... April 21, 2017 , ... ... recognized outstanding manufactures in 10 categories with over 30 nominees and well as ... Manufacturing presented the new award and the event was hosted by CompanyWeek and ...
(Date:4/21/2017)... ... April 21, 2017 , ... Frederick Innovative Technology Center, ... emerging bio and technology start-ups, is hosting “Celebration Friday” (a festive gathering highlighting ... start with libations and networking at 3:30 p.m. at FITCI’s 4539 Metropolitan Court ...
(Date:4/20/2017)... ... April 20, 2017 , ... USDM Life Sciences , ... sciences and healthcare industries, is pleased to announce Holger Braemer as Vice ... “USDM Europe GmbH” based in Germany. , Braemer is an integral part of ...
Breaking Biology Technology: