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Molecule serves as a key in some protein interactions
Date:11/4/2011

new route to generating small- molecule inhibitors," Schulman said. Pharmaceutical companies are already targeting other parts of the same NEDD8 pathway, and one experimental drug has entered clinical trials.

Not only does Ubc12's acetylated tail fit perfectly into the pocket, but acetylation solved another problem that would have made the interaction of Ubc12 and Dcn1 difficult. Without acetylation, Ubc12 and the Dcn1 pocket would repel each other much like oil and water. Acetylation neutralizes the charge on Ubc12, allowing the interaction to occur, Schulman said.


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Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert  

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