Navigation Links
Molecule involved in heart failure now implicated in heart attack damage
Date:9/15/2010

le function in heart cells. This braking action is enhanced in chronic heart failure, and relieving it by inhibiting activity and expression of GRK2 allows the heart to work better, the researchers have shown in animal studies using gene therapy.

The question they looked at in this study is whether GRK2 plays any role after a heart attack. Most cardiology researchers theorized that it was protective, because expression of the protein is increased by three to four times immediately after a heart attack, Dr. Koch says. "People always thought that GRK2 was working to shut off beta receptors because injured hearts were pumping out too much adrenaline, and that this blocking of over activity in an injured heart is protective."

But what the researchers discovered is that over production of GRK2 following a heart attack actually stimulates pro-death pathways in myocyctes (heart cells) outside of the initial zone of damage. They specifically found an inverse link between GRK2 activity and the production of nitric oxide (NO), a molecular messenger that protects the heart against damage caused by a sudden loss of blood. "When there is more GRK2, there is less NO, and vice versa," Dr. Koch says. They believe that GRK2 may be affecting NO production by inhibiting the prosurvival protein kinase Akt, which itself regulates NO. (more)

The mice MI studies then proved that inhibiting GRK2 protected heart cells, Dr. Koch says.

"Our results clearly show that GRK2 is a pathological target in the heart, involved in both progressive heart failure and in death of heart cells after a heart attack," he says.


'/>"/>

Contact: Rick Cushman
richard.cushman@jefferson.edu
215-955-2240
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists identify a molecule that coordinates the movement of cells
2. RNA molecules, delivery system improve vaccine responses, effectiveness
3. Brain-nourishing molecule may predict schizophrenia relapse
4. Bare bones of crystal growth: Biomolecules enhance metal contents in calcite
5. Linking Proteins, Wires, Dots, and Molecules into Useful Devices
6. Purdue researcher invents molecule that stops SARS
7. Argonne scientists discover possible mechanism for creating handedness in biological molecules
8. Molecules in the spotlight
9. Shape changes in aroma-producing molecules determine the fragrances we detect
10. SUNY Downstate researchers find that memory storage molecule preserves complex memories
11. UC Davis researchers find molecule that targets brain tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/1/2015)...   Medisafe ™, the leading global medication management ... and Android smartphones and tablets, announces ... platform to allow patients to track and correlate their ... patients will be able to visualize in real-time how ... such as glucose levels and blood pressure. ...
(Date:3/30/2015)... Mar. 26, 2015 Research and Markets ... "Global Gesture Recognition Market in Automotive Sector 2014-2018" ... forecast the Global Gesture Recognition market in Automotive Sector ... period 2013-2018. Gesture recognition is the ability ... gestures of an individual. Gesture recognition technology can be ...
(Date:3/24/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the ... Business Report" report to their offering. This report ... Thousands by the following Segments: Face Biometrics, and Voice Biometrics. The ... , Japan , Europe ... & Africa , and Latin ...
Breaking Biology News(10 mins):Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6
... NY, November 20, 2012Mary Ann Liebert, Inc., publishers ... journal dedicated to the science and engineering of soft materials ... first to answer the urgent need for research on robotic ... in complex natural or human-built environments. Soft Robotics ...
... during cardiac surgery can lead to convulsive seizures, but ... research from the Faculty of Medicine at the University ... trauma surgery are often given tranexamic acid (TXA) and ... of Medicine researchers found these drugs are associated with ...
... atomic physics over the past few years are methods that ... temperatures just above absolute zero. Scientists from Bangalore and Mainz ... also be cooled through contact with cold atoms and may ... condition for longer periods of time. This finding runs counter ...
Cached Biology News:'Soft Robotics': A groundbreaking new journal on engineered soft devices that Interact with Living Systems 2Seizures linked to surgery drugs can be prevented by anesthetics, U of T team finds 2Scientists from Bangalore and Mainz develop new methods for cooling of ions 2
(Date:5/5/2015)... , May 5, 2015  Renova™ Therapeutics, ... congestive heart failure and other chronic diseases, has ... independent analysis designed to reflect the healthcare patterns ... This model will be used to characterize the ... could have on those groups of patients and ...
(Date:5/5/2015)... Oakland, CA (PRWEB) May 05, 2015 ... Database technology, today announced that its flagship product, AllegroGraph, ... recent Graph Database Market Update report. AllegroGraph ... by leveraging the W3C industry standards. Graph databases are skyrocketing ... two years, according to a recent DBMS ranking ...
(Date:5/5/2015)... 5, 2015   Tocagen Inc. , a ... R. Parkinson , M.D., a venture partner at ... the board of directors of Tocagen. Dr. Parkinson ... oncology clinical development, including leading clinical activities at ... of the cancer therapeutics Gleevec®, Femara®, Zometa®, Kepivance® ...
(Date:5/5/2015)... The Alliance for Clinical Research Excellence and Safety ... public interest, and Texas-based for-profit San Antonio Express-News ... formed a strategic alliance to create a blog as ... healthcare and clinical research endeavor. The blog provides ... public to be clearly heard in this important dialogue. ...
Breaking Biology Technology:RAND Health Advisory Services modeling heart failure patient outcomes to inform potential impact of Renova Therapeutics lead product candidate 2RAND Health Advisory Services modeling heart failure patient outcomes to inform potential impact of Renova Therapeutics lead product candidate 3Bloor Research Positions AllegroGraph as a ‘Champion’ in Burgeoning Graph Database Market 2Bloor Research Positions AllegroGraph as a ‘Champion’ in Burgeoning Graph Database Market 3Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 2Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 3Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 4ACRES and San Antonio Express-News Launch Blog on Accountability in Clinical Research 2ACRES and San Antonio Express-News Launch Blog on Accountability in Clinical Research 3ACRES and San Antonio Express-News Launch Blog on Accountability in Clinical Research 4
... Nanotechnology Victoria (NanoVic) and AZoNetwork are pleased to ... in a Podcast format. , This third Podcast ... features key stakeholders discussing the crucial issues around ... development and translated into successful commercial outcomes. , Dr ...
... Bulletin Board: CNVT) holding BIOREM announced the,receipt of a ... a,Biofiltair odor control system. This order for $280,000 (Cdn) ... is the third order,received from China over the past ... was accepted on these projects,",said Peter Bruijns, President and ...
... RDEA ) today announced that its President and ... the "In Search of the,Next HIV Treatment" panel discussion ... December 12, 2007 at 1:30 p.m. (ET) at,the Westin ... audio webcast of the,presentation and panel discussion will be ...
Cached Biology Technology:Commercialization of nanotechnology 2CVF Technologies Corporation's Holding - BIOREM Announces 3rd Order from China 2Ardea Biosciences to Participate in RBC Capital Markets 2007 Healthcare Conference 2Ardea Biosciences to Participate in RBC Capital Markets 2007 Healthcare Conference 3
... 21 CFR part 11, Compliant software for JASCO HPLC systems. ... ... number of control software options for JASCO HPLC systems. This provides ... and record all instrument settings with each run. , ...
Rabbit anti Xanthine Oxidase Xanthine Oxidase, Bovine Buttermilk...
... Introducing SilverSNAP Stain for Mass Spectrometry Applications ... mass spectrometry (MS) has emerged as a ... staining of 2-D gels is now an ... procedures that leads ultimately to identification of ...
... Mammalian Protein Extraction Reagent is ... solution that means no scraping, ... sonication! With M-PER Reagent, rapid ... minutes at room temperature, yielding ...
Biology Products: