Navigation Links
Molecular switches age-related memory decline? Genetic variant protect against brain aging
Date:5/6/2014

Philadelphia, PA, May 6, 2014 Even among the healthiest individuals, memory and cognitive abilities decline with age. This aspect of normal aging can affect an individual's quality of life and capability to live independently but the rate of decline is variable across individuals. There are many factors that can influence this trajectory, but perhaps none more importantly than genetics.

Scientists are seeking to identify key molecular switches that control age-related memory impairment. When new molecules are identified as critical to the process of memory consolidation, they are then tested to determine whether they contribute to the memory problems of the elderly.

One of these proteins is called KIBRA and the gene responsible for its production is WWC1. KIBRA is known to play a role in human memory and so researchers at the Lieber Institute for Brain Development and the National Institute of Mental Health, led by senior author Dr. Venkata Mattay, conducted a study to determine the effects of genetic variants in WWC1 on memory. Their findings are published in the current issue of Biological Psychiatry.

"Identifying these genetic factors, while helping us better understand the neurobiology of cognitive aging, will also aid in identifying mechanisms that confer individuals with resilience to withstand the inevitable age-related changes in neural architecture and function," explained Mattay.

Using imaging genetics, a method that combines genetics with brain imaging technology, the team explored the effect of a variant in the WWC1 gene on age-related changes in memory function. The particular WWC1 variant under investigation has three potential forms CC, TT, or CT.

They recruited 233 healthy volunteers, who ranged in age from 18-89 years. The volunteers completed a battery of cognitive tests, underwent genotyping, and completed a memory task during a brain imaging scan.

They found that individuals who
'/>"/>

Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
2. Beyond the microscope: Identifying specific cancers using molecular analysis
3. 2012 Forecast for US Molecular Diagnostics Market Now Available From Global Information Inc.
4. 5th Annual Advances in Biomolecular Engineering Symposium
5. PNAS: Precise molecular surgery in the plant genome
6. Molecular spectroscopy tracks living mammalian cells in real time as they differentiate
7. Hitting snooze on the molecular clock: Rabies evolves slower in hibernating bats
8. The activity of a bacterial effector protein seen in molecular detail
9. How bacteria change movement direction in response to oxygen: Molecular interactions unravelled
10. MARC travel award announced for the 2012 GSA Yeast Genetics and Molecular Biology Meeting
11. Highlighting molecular clues to the link between childhood maltreatment and later suicide
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Valencell, a leader in performance biometric data sensor technology, ... such as Intel, Jabra, Atlas, and Scosche to develop ... products will be showcased at CES 2015, taking place ... "Our partners choose PerformTek biometrics, because ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition of the ... their offering. One major trend emerging ... systems. Multimodal biometric systems utilize more than one characteristic ...
(Date:12/10/2014)... Forest Baptist Medical Center today announced plans for a new ... this $50 million capital project is part of a larger ... The medical education building will be located in ... to 525@vine in Wake Forest Innovation Quarter. Construction will begin ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... green, rolling hills and farmlands around Lexington, Kentucky, Darrell Taulbee ... fertilizer. But hes not looking to grow a better Big ... by the University of Kentucky and the Homeland Securitys Science ... far more sinister. Darrell Taulbee putters with this ...
... initiated a ground breaking clinical trial to determine the ... to decrease the risk of immune reactions common in ... hope the experimental cellular therapy will improve overall survival ... a potential new paradigm for treating autoimmune diseases., ...
... the sailor,s lore of fearsome battles between sperm whale ... How did these leviathans develop the underwater sonar needed ... Now, two evolutionary biologists at the University of ... to chase flying insects through the darkness, dolphins and ...
Cached Biology News:Brewing a blast-less fertilizer 2U of M begins nation's first clinical trial using T-reg cells from cord blood in leukemia treatment 2Migrating squid drove evolution of sonar in whales and dolphins, researchers argue 2Migrating squid drove evolution of sonar in whales and dolphins, researchers argue 3Migrating squid drove evolution of sonar in whales and dolphins, researchers argue 4
(Date:1/22/2015)... 2015 The laboratory information management systems ... a number of technological advancements due to factors such ... need to integrate healthcare systems, and increasing government support ... system integration. Key players in the market focus on ...
(Date:1/22/2015)... 2015 zFlo Motion , a US ... an exciting product from a new partner. STT-Systems ... the past 15 years, with offerings in the optical-motion capture, ... IMU system (inertial measurement unit), iSen, is opening eyes around ...
(Date:1/22/2015)... Diagenode, Inc., a leading global provider ... complete solutions for epigenetics research, recently launched a ... need for manual processing. The new ChIPettor System ... histones or transcription factors and a semi-automated pipette ...
(Date:1/22/2015)... , Jan. 22, 2015   GenoSpace , a precision medicine ... to enable the broad use of genomic, imaging and other ... appointment of Michelle Munson , CEO of Aspera, an ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 "We ...
Breaking Biology Technology:Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 43D Motion Capture Just Got Easy 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2GenoSpace Expands Board with Appointment of Michelle Munson 2
... , ... Group is pleased to announce that Dr. Michael Langley is joining the company as ... served many roles during his career with Lilly in both animal science and human ... led a number of successful regulatory engagements including both European and US regulatory submissions. ...
... , WINSTON-SALEM, N.C. , Jan. 29 ... They are the stars of a new animated film, "Cell Side ... in cooperation with Wake Forest University and other community ... and female animated characters that dramatize what happens within cells. ...
... Jan. 28 Tissue Genesis, Inc., an emerging leader ... Medical Systems Holdings, Inc. (Nasdaq: AMMD ) announced today ... of adipose (fat)–derived regenerative cells for use in treating pelvic ... over the life of the agreement to obtain rights ...
Cached Biology Technology:Michael Langley, DVM, MBA, RAC Joins the Anson Group as a Regulatory Consultant 2New Musical 'Cell Side Story' Puts Science on Stage 2New Musical 'Cell Side Story' Puts Science on Stage 3American Medical Systems and Tissue Genesis Sign $1.1 Million Collaboration Deal 2American Medical Systems and Tissue Genesis Sign $1.1 Million Collaboration Deal 3American Medical Systems and Tissue Genesis Sign $1.1 Million Collaboration Deal 4
... 1,4-Dithiothreitol DTT ... Purity: ≥99% by titration. ... (100 mM, 1 cm, 260 nm): ≤0.500; ... Heavy metals: ≤0.001%. Soluble ...
... Basically, most ``special`` dye stains are ... few other non-routine) stains are $9.00. ... a paraffin block, staining, coverslipping and ... (for senile plaques) ,Bodian`s Stain ,Copper ...
... Dithiothreitol DTT White solid.. PACKAGED ... to thiols, so reaction is "driven" to completion. ... contain waxy surfactant found in many other preparations. ... Purity: ≥97% by titration. Contaminants: ...
... This kit is designed for easy ... The protocol allows for successful transformation simply ... kit reagents with cultured yeast cells. No ... washing, are required. The kit is particularly ...
Biology Products: