Navigation Links
Molecular switches age-related memory decline? Genetic variant protect against brain aging
Date:5/6/2014

Philadelphia, PA, May 6, 2014 Even among the healthiest individuals, memory and cognitive abilities decline with age. This aspect of normal aging can affect an individual's quality of life and capability to live independently but the rate of decline is variable across individuals. There are many factors that can influence this trajectory, but perhaps none more importantly than genetics.

Scientists are seeking to identify key molecular switches that control age-related memory impairment. When new molecules are identified as critical to the process of memory consolidation, they are then tested to determine whether they contribute to the memory problems of the elderly.

One of these proteins is called KIBRA and the gene responsible for its production is WWC1. KIBRA is known to play a role in human memory and so researchers at the Lieber Institute for Brain Development and the National Institute of Mental Health, led by senior author Dr. Venkata Mattay, conducted a study to determine the effects of genetic variants in WWC1 on memory. Their findings are published in the current issue of Biological Psychiatry.

"Identifying these genetic factors, while helping us better understand the neurobiology of cognitive aging, will also aid in identifying mechanisms that confer individuals with resilience to withstand the inevitable age-related changes in neural architecture and function," explained Mattay.

Using imaging genetics, a method that combines genetics with brain imaging technology, the team explored the effect of a variant in the WWC1 gene on age-related changes in memory function. The particular WWC1 variant under investigation has three potential forms CC, TT, or CT.

They recruited 233 healthy volunteers, who ranged in age from 18-89 years. The volunteers completed a battery of cognitive tests, underwent genotyping, and completed a memory task during a brain imaging scan.

They found that individuals who
'/>"/>

Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
2. Beyond the microscope: Identifying specific cancers using molecular analysis
3. 2012 Forecast for US Molecular Diagnostics Market Now Available From Global Information Inc.
4. 5th Annual Advances in Biomolecular Engineering Symposium
5. PNAS: Precise molecular surgery in the plant genome
6. Molecular spectroscopy tracks living mammalian cells in real time as they differentiate
7. Hitting snooze on the molecular clock: Rabies evolves slower in hibernating bats
8. The activity of a bacterial effector protein seen in molecular detail
9. How bacteria change movement direction in response to oxygen: Molecular interactions unravelled
10. MARC travel award announced for the 2012 GSA Yeast Genetics and Molecular Biology Meeting
11. Highlighting molecular clues to the link between childhood maltreatment and later suicide
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/17/2015)... , March 17, 2015 MedNet ... specializing in clinical study management systems, is pleased ... attendance at ARENA,s Outsourcing in Clinical Trials Southeast ... event provides an excellent forum for MedNet to ... and affordable software-as-a-service (SaaS) eClinical technology platform. ...
(Date:3/16/2015)... Between 16 and 20 ... innovations in biometric identification at the CeBIT exhibition ...      (Photo: http://photos.prnewswire.com/prnh/20150316/735333 ) , ... at the forefront: the company,s all new BiometricGate ... Germany . BiometricGate is the first ...
(Date:3/12/2015)... , March 12, 2015 ... a standardized identity and access management (IAM) solution ... implementation schedule. With Beta System,s new IAM package, ... best practices gleaned from multiple IAM implementations across ... the software as well as any necessary services ...
Breaking Biology News(10 mins):Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2
... Virginia Key, Fla. -- Ronald Hoenig and Aaron ... Miami (UM) Rosenstiel School of Marine UM Rosenstiel ... 6th Rothschild Entrepreneurship Competitionand Atmospheric Science, won first ... years 6th Annual Leigh Rothschild Entrepreneurship Competition. ...
... at San Antonio will bring together energy leaders, industry ... hosts the inaugural UTSA North American Energy Summit (NAES) ... UTSA Downtown Campus. The summit will feature experts with ... addressing the energy needs for future generations. ...
... the latest American Chemical Society (ACS) News Service Weekly PressPac ... Engineering News.,Please credit the individual journal or the American Chemical ... IS FOR IMMEDIATE USE EXCEPT ARTICLE #5, which is embargoed ... ARTICLE #1 FOR IMMEDIATE RELEASE Study calls for ...
Cached Biology News:Aquaculture concept leaves judges 'goggle eyed' 2UTSA hosts North American Energy Summit May 1-2 2American Chemical Society's Weekly PressPac -- April 23, 2008 2American Chemical Society's Weekly PressPac -- April 23, 2008 3American Chemical Society's Weekly PressPac -- April 23, 2008 4American Chemical Society's Weekly PressPac -- April 23, 2008 5American Chemical Society's Weekly PressPac -- April 23, 2008 6American Chemical Society's Weekly PressPac -- April 23, 2008 7American Chemical Society's Weekly PressPac -- April 23, 2008 8
(Date:3/25/2015)... market is one of the most attractive in the ... plus a growing economy and increasing government investment in ... The Russian market is set to grow at twice ... estimates around 10-15% annually reaching an approximate market value ... Cross Green Cross provides total healthcare solutions ...
(Date:3/25/2015)... (PRWEB) March 25, 2015 The ... of smartphones have fuelled social media growth, with ... currently engaged in social networking. Insurance companies are ... communicate with clients and promote a diversity of ... over are increasingly exploiting social networking services as ...
(Date:3/25/2015)... and REYKJAVIK, Iceland , March 25, 2015 ... the genome to create better medicine, today congratulated the scientists ... of whole-genome data yet undertaken. The studies ... – are built around the most comprehensive population-wide tally ... deCODE scientists led by Kari Stefansson , deCODE,s founder ...
(Date:3/25/2015)... 2015 Having added two International locations ... of 2014, ITRA Global proudly announced recently the organization’s ... Representative Alliance, based in the United States, is one ... occupiers of commercial real estate. , Saltwood International ... Poland that exclusively advises occupiers of office space, ensuring ...
Breaking Biology Technology:Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 2Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 3Landmark deCODE Studies Demonstrate the Power of Truly Big Genomics for Improving Medicine Worldwide 2International Organization Expands its Global Reach to Warsaw, Poland 2
... a,biotechnology company translating the complexity of human biology to,develop ... manager of its Scientific Programs, was selected by Mass ... "We are proud to have a young, successful individual ... O. Elliston, president and CEO at,Genstruct. "She has been ...
... of Venous Thromboembolism -, LEXINGTON, Mass., Oct. ... US Food and Drug Administration (FDA) has,granted 510(k) ... D-Dimer HS,to exclude venous thromboembolism (VTE) in outpatients ... (PE), when used in conjunction,with a clinical pretest ...
... Oct. 9 A homegrown New Jersey company ... pedigree of pharmaceuticals everywhere. Secure Symbology, (http://www.securesymbology.com ), ... as an,Honored Finalist as Emerging Business of the ... for its vision to wipe out counterfeit drugs,worldwide. ...
Cached Biology Technology:Genstruct's Andrea Matthews Selected for Mass High Tech's 'People to Watch Under 30' 2Instrumentation Laboratory Receives FDA Clearance to Expand the Intended Use for HemosIL(R) D-Dimer HS Assay 2Secure Symbology: Making New Jersey Proud While Saving Lives 2
... FXP is the latest entry in the Biomek ... accuracy and increased robustness, it can meet the ... be configured with either one or two pipetting ... FXP sets the standard for flexible laboratory solutions ...
... FX P is the latest entry in ... greater positional accuracy and increased robustness, it can ... It can be configured with either one or ... the Biomek FX P sets the standard ...
... Simplify the process and you reduce ... built into the CEQ 8000. Developed using ... and leadership in capillary electrophoresis technology, the ... analysis system. This system automatically fills the ...
... a simple high performance method for removing ... without significant dilution of protein solution. ... Detergent-OUT Spin column and collect detergent free ... suitable for removing detergents from a 1.0 ...
Biology Products: