Navigation Links
Molecular muscle: Small parts of a big protein play key roles in building tissues
Date:3/23/2011

tissue that has been damaged."

If the extracellular matrix were a construction site, tenascin-C could be seen as the scaffold upon which the weaving of fibronectin threads, or fibrils, is done. "Tenascin-C has multiple arms, and we have shown that it has multiple binding sites for fibronectin," Midwood says. "In this way, it can bind to many fibronectin fibrils at once and help to form the whole tissue by linking the fibrils together. Then, when the repair is done, the scaffolding is taken down."

Midwood and To systematically determined where tenascin-C and fibronectin bind together. They also identified small parts of tenascin-C, known as domains, that can bind to only one fibronectin fibril apiece.

"The small domains act as caps of the scaffold. No more fibronectin fibrils can bind once these caps are in place," Midwood says. So, in essence, they found that certain pieces of tenascin-C determine when fibril building should stop once enough, but not too much, tissue is made.

The findings could be especially useful for creating therapies for conditions in which there is aberrant extracellular matrix deposition, such as in cancers, fibrotic conditions or chronic non-healing wounds, adds To.

In abnormal conditions, such as in the case of a tumor cell, "the home that's made of fibronectin helps it to survive, shelters it and provides signals that enable it to proliferate," says Midwood. "As the tumor thrives, the home keeps on growing, expanding to destroy the existing neighborhood."

Similarly, in fibrotic diseases, tissue rebuilding rages out of control with too much fibronectin assembly so that it takes over the whole affected organ, Midwood says.

"In the end, we found that tenascin-C has both stop and go functions cleverly concealed in the same molecule," Midwood says. "The large spiderlike protein may provide a scaffold for building, and the small domains of the protein block excess building. Small
'/>"/>

Contact: Angela Hopp
ahopp@asbmb.org
301-634-7389
American Society for Biochemistry and Molecular Biology
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Salk scientists crack molecular code regulating neuronal excitability
2. New molecular robot can be programmed to follow instructions
3. Molecular mechanism contributing to neuronal circuit formation found
4. Combined molecular study techniques reveal more about DNA proteins
5. Fingerprints match molecular simulations with reality
6. Designing new molecular tools to study the life and death of a cancer cell
7. Molecular network influences development of chronic lymphocytic leukemia
8. Polymer membranes with molecular-sized channels that assemble themselves
9. Molecular medicine could avert predicted catastrophic vision loss in the aged
10. New book highlights the cellular and molecular determinants of brain wiring
11. Scientists discover molecular switch that contributes to cellular aging process
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecular muscle: Small parts of a big protein play key roles in building tissues 
(Date:9/22/2014)... in the country selected by the National Institutes ... Award a $2 million grant designed to ... sciences graduate trainees to career opportunities that go ... taken. , The award funds development of the ... program. It includes courses, seminars, shadowing, mentoring and ...
(Date:9/22/2014)... Evacuations of 2,819 people have occurred in the wake ... near the Eldorado National Forest. The King Fire ... of the American River Canyon, Silver Creek Canyon, and ... Pines. The fire has crossed into Placer County and ... Eldorado National Forest. The anticipated spread is expected to ...
(Date:9/21/2014)... General Assembly events focussed on ways to save and ... Challenges Canada, funded by the Government of Canada, today ... to address this challenge. , The novel approaches include: ... working in garment factories to express, pasteurize and store ... due to child illnesses, and lowering baby formula expense ...
Breaking Biology News(10 mins):Rutgers receives $2 million grant to prepare biomedical students for roles in industry 2Rutgers receives $2 million grant to prepare biomedical students for roles in industry 3Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 2Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 3Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 4Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 5Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 6Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 7Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 8Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 9Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 10Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 11Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 12Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 13Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 14Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 15
... 2010 Cellular imaging offers a wealth of data ... technique to study biological systems is a daunting challenge. ... Research ( www.genome.org ), researchers have developed a ... identify genetic interactions within biological networks, offering a glimpse ...
... in third-hand smoke, the residue from tobacco smoke that ... has been extinguished, reacts with the common indoor air ... potential health hazard was revealed in a multi-institutional study ... (Berkeley Lab). "The burning of tobacco releases nicotine ...
... Advanced maternal age is linked to a significantly elevated risk ... age, according to an exhaustive study of all births in ... Advanced paternal age is associated with elevated autism risk only ... 30, the study found. Published online today in the ...
Cached Biology News:Method of the future uses single-cell imaging to identify gene interactions 2Study reveals new details on the dangers of third-hand smoke 2Study reveals new details on the dangers of third-hand smoke 3Study reveals new details on the dangers of third-hand smoke 4UC Davis study confirms link between advanced maternal age and autism 2UC Davis study confirms link between advanced maternal age and autism 3UC Davis study confirms link between advanced maternal age and autism 4
(Date:9/22/2014)... Mass. , Sept. 22, 2014 ... GEVA ), a biopharmaceutical company developing therapeutic ... of Robert Bazemore as Chief Operating ... , President and Chief Executive Officer, Robert will ... company,s lead program, sebelipase alfa for LAL Deficiency, ...
(Date:9/21/2014)... have discovered how to produce ultra-thin "diamond nanothreads" that ... that of today,s strongest nanotubes and polymers. A paper ... John V. Badding, a professor of chemistry at Penn ... 2014 issue of the journal Nature Materials . ... is intriguing because the threads we formed have a ...
(Date:9/20/2014)... Austin, Texas (PRWEB) September 20, 2014 ... of integrated urological and interventional radiology products and ... Endocare, Inc. subsidiary with Clinicon Corporation ... addition expands HealthTronics’ portfolio of minimally invasive, mobile, ... their patients. , Under the agreement, HealthTronics will ...
(Date:9/19/2014)... is rarely simple. From crop yields to disease risks, ... those considered "complex traits." Just as for heightthe textbook ... particular human disease are shaped by multiple genetic and ... involved. To track down such genes, geneticists typically mate ... large mouse and a small mouseand then study their ...
Breaking Biology Technology:Synageva BioPharma Appoints Robert Bazemore As Chief Operating Officer 2Synageva BioPharma Appoints Robert Bazemore As Chief Operating Officer 3Synageva BioPharma Appoints Robert Bazemore As Chief Operating Officer 4Smallest possible diamonds form ultra-thin nanothreads 2Smallest possible diamonds form ultra-thin nanothreads 3Smallest possible diamonds form ultra-thin nanothreads 4HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 2HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 3Want to link genes to complex traits? Start with more diversity 2
... 2011 Arecor, the leading company ... and vaccines, is pleased to announce the appointment ... Howell will be responsible for the operations of ... Arecor,s upward growth curve ensuring the company continues ...
... Nov. 10, 2011 Avaxia Biologics, Inc. , ... act locally within the gastrointestinal tract, announced today that ... of a Series A angel-led financing. Cherrystone Angels of ... Boston Harbor Angels and other undisclosed individuals. Mr. Robert ...
... Discovery Laboratories, Inc. (Nasdaq: DSCO ), ... respiratory critical care, today reports financial results for the third ... of the SURFAXIN® and AFECTAIR™ programs.  The Company will host ... call details are below. Selected third quarter highlights ...
Cached Biology Technology:Arecor Appoints Dr. Sarah Howell as Chief Operating Officer 2Avaxia Biologics, Inc. Raises $2.2 Million in First Closing of Series A Financing to Advance Oral Antibodies for Inflammatory Bowel Disease 2Discovery Labs Reports Third Quarter Financial Results and Progress on Lead Programs 2Discovery Labs Reports Third Quarter Financial Results and Progress on Lead Programs 3Discovery Labs Reports Third Quarter Financial Results and Progress on Lead Programs 4Discovery Labs Reports Third Quarter Financial Results and Progress on Lead Programs 5Discovery Labs Reports Third Quarter Financial Results and Progress on Lead Programs 6Discovery Labs Reports Third Quarter Financial Results and Progress on Lead Programs 7Discovery Labs Reports Third Quarter Financial Results and Progress on Lead Programs 8Discovery Labs Reports Third Quarter Financial Results and Progress on Lead Programs 9
Mouse monoclonal [RL13] to LAP1 ( Abpromise for all tested applications). SwissProtID: Q96NW7...
CircuLex Anti-Human S100P Polyclonal Antibody Research Focus: proliferation Storage: -20C Shipping Temperature: 4C...
Mouse monoclonal [7E10] to C Peptide ( Abpromise for all tested applications). entrezGeneID: 3630 SwissProtID: P01308...
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide...
Biology Products: