Navigation Links
Molecular movements of neural transporters unveiled
Date:4/25/2011

NEW YORK (April 24, 2011) -- A team of scientists from Columbia University College of Physicians and Surgeons and Weill Cornell Medical College has shed light on the molecular workings of transporter proteins, molecular machines embedded in the cell membranes of neurons that modulate the transfer of signals between cells and recycle neurotransmitters.

The research, published today in the journal Nature, reveals with unprecedented detail how the molecule performs its task, says one of the senior authors, Dr. Jonathan Javitch, the Lieber Professor of Experimental Therapeutics in Psychiatry and professor of pharmacology in the Center for Molecular Recognition at Columbia University Medical Center. "This level of understanding may ultimately lead to improved treatments for psychiatric disorders and increase our understanding of how drugs such as cocaine work."

In the brain, one neuron communicates to another by releasing chemicals called neurotransmitters into the gap between them, called the synapse. To stop the signal, specialized transporters must remove the released neurotransmitter from the synapse by pumping it back into the releasing cell. In the treatment of some diseases it is beneficial, however, to allow the neurotransmitters to build up in the synapses. Antidepressants make this possible by interfering with particular transporters, as do stimulant drugs like cocaine and amphetamines.

Neuronal cells have different transporters. One family of transporters, known as neurotransmitter/sodium symporters (NSSs) are specialized for the uptake of certain neurotransmitters, including dopamine, noradrenaline and serotonin. They are named symporters because the transport process requires energy to concentrate neurotransmitter inside neurons -- the energy required is provided by the imbalance of sodium ions across the cell membrane. Thus, sodium ions flow down their concentration gradient into the neurons through the NSSs, thereby a
'/>"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. SNM releases new fact sheet on breast cancer and molecular imaging
2. Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
3. A new journal where molecular biology meets clinical research
4. Scientists trace molecular origin of proportional development
5. New molecular insight into vertebrate brain development
6. Plants display molecular amnesia
7. Pitt, NETL researchers report molecular chain reaction thought to be impossible
8. Tracking the molecular pathway to mixed-lineage leukemia
9. Researchers compile molecular manual for 100s of inherited diseases
10. Biologists learn structure, mechanism of powerful molecular motor in virus
11. Phoenix conference highlights TGens and Scottsdale Healthcares contributions to molecular oncology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... A decade-long effort by members of the International Glossina ... sequence of the tsetse fly, Glossina morsitans . ... sickness, a potentially deadly disease endemic in sub-Saharan Africa. ... develop new ways to prevent the disease and provide ... tsetse fly is quite unique in the insect world: ...
(Date:4/24/2014)... 2014D-ribose is a commercially important sugar used as ... starting compound for synthesizing riboflavin and several antiviral ... to increase the bacteria,s ability to produce D-ribose ... industrial-scale production of this valuable chemical, as described ... a peer-reviewed journal from Mary Ann Liebert, Inc., ...
(Date:4/24/2014)... Ludwig-Maximilians-Universitaet (LMU) in Munich have identified the structural ... discriminate between viral and endogenous RNAs in living ... control of cellular metabolism and hijack cellular resources ... is dependent on viral RNA molecules that are ... viruses) and/or newly synthesized in the host cell, ...
Breaking Biology News(10 mins):Genetic code of the deadly tsetse fly unraveled 2Viral infections: Identifying the tell-tale patterns 2Viral infections: Identifying the tell-tale patterns 3
... and roads really curb carbon emissions and combat global climate ... a new study by researchers at Lawrence Berkeley National Laboratory ... study the question has found that implementing cool roofs and ... help cities stay cooler, they can also cool the world, ...
... -- (July 19, 2010) -- Bioengineers from Rice University,s ... from the National Institutes of Health to develop an ... can spur the growth of new cartilage in injured ... with pain, limited mobility and arthritis that often result ...
... January 2011, Springer will publish the Journal of ... the International Society for NeuroVirology. Previously published by Taylor ... 2015. The Journal of NeuroVirology ... molecular biology and pathogenesis of viral infections of the ...
Cached Biology News:Global model confirms: Cool roofs can offset carbon dioxide emissions and mitigate global warming 2Global model confirms: Cool roofs can offset carbon dioxide emissions and mitigate global warming 3Global model confirms: Cool roofs can offset carbon dioxide emissions and mitigate global warming 4Global model confirms: Cool roofs can offset carbon dioxide emissions and mitigate global warming 5NIH awards Rice $1.7M for cartilage-regeneration research 2
(Date:1/14/2014)... , Jan. 14, 2014   Kinaxis ®, provider of ... and sales and operations planning ( S&OP ) service, is ... Summit , which will be held at the Hilton San ... join Kinaxis customer Elisabeth Kaszas , Director of Supply ...
(Date:1/14/2014)... Kerr Corporation, a leading manufacturer of innovative dental ... about dual arch impressions on its dental blog. ... blog entry serves up a list of tips to help ... by Dr. David Little as he crafts a porcelain crown ...
(Date:1/14/2014)... January 14, 2014 Independent publisher Bitingduck ... and Montreal, Canada, has big ideas for 2014 in ... press's goals are to produce high-quality, low-cost, DRM-free ebooks ... local businesses. , The first major development will ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Holloway America ... database of material test reports (MTRs) for all pressure ... Documenting test results is particularly important for equipment that ... The MTR Library features search functionality that allows authorized ...
Breaking Biology Technology:Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2Bitingduck Press Looks Forward to 2014 With Multimedia E-books 2Pressure Vessel Design and Fabrication Company Builds Database for Material Test Reports 2Pressure Vessel Design and Fabrication Company Builds Database for Material Test Reports 3
... The University of Wisconsin-Madison says it has bought a new ... Printer has a better "enlarge" feature than the typical office ... cells, DNA double helixes and the Anthrax virus. , ,Using ... up to 10 inches tall one layer at a time. ...
... can submit executive summaries of their businesses for angel ... May 9. , ,The Wisconsin Angel Network ... investor networks with entrepreneurs based on the investors' market ... a deal-flow pipeline, has been designed to be a ...
... proper networking techniques, you may not be maximizing your time ... While people have their own networking style that works for ... to do what works best for you and your personality. ... ideas about networking from other professionals who have been successful. ...
Cached Biology Technology:Start-ups, angels can connect on new state Web site 2Start-ups, angels can connect on new state Web site 3Improve your networking skills by learning from other professionals 2Improve your networking skills by learning from other professionals 3Improve your networking skills by learning from other professionals 4
Request Info...
... Microtube Rotor is TWO ROTORS in ONE! ... You can spin both 1.5 - ... polypropylene rotor design provides excellent chemical resistance ... rotors are fully compatible with common decontamination ...
... 384, compatible with hood ... handling system for 384-well ... accurately prepares large quantities ... The Wellpro also performs ...
... offers lower consumption of reagents and ... The Multidrop 384 is an automated ... microvolume dispensing into 384- and 96-well ... It can easily switch from 96- ...
Biology Products: