Navigation Links
Molecular movements of neural transporters unveiled
Date:4/25/2011

NEW YORK (April 24, 2011) -- A team of scientists from Columbia University College of Physicians and Surgeons and Weill Cornell Medical College has shed light on the molecular workings of transporter proteins, molecular machines embedded in the cell membranes of neurons that modulate the transfer of signals between cells and recycle neurotransmitters.

The research, published today in the journal Nature, reveals with unprecedented detail how the molecule performs its task, says one of the senior authors, Dr. Jonathan Javitch, the Lieber Professor of Experimental Therapeutics in Psychiatry and professor of pharmacology in the Center for Molecular Recognition at Columbia University Medical Center. "This level of understanding may ultimately lead to improved treatments for psychiatric disorders and increase our understanding of how drugs such as cocaine work."

In the brain, one neuron communicates to another by releasing chemicals called neurotransmitters into the gap between them, called the synapse. To stop the signal, specialized transporters must remove the released neurotransmitter from the synapse by pumping it back into the releasing cell. In the treatment of some diseases it is beneficial, however, to allow the neurotransmitters to build up in the synapses. Antidepressants make this possible by interfering with particular transporters, as do stimulant drugs like cocaine and amphetamines.

Neuronal cells have different transporters. One family of transporters, known as neurotransmitter/sodium symporters (NSSs) are specialized for the uptake of certain neurotransmitters, including dopamine, noradrenaline and serotonin. They are named symporters because the transport process requires energy to concentrate neurotransmitter inside neurons -- the energy required is provided by the imbalance of sodium ions across the cell membrane. Thus, sodium ions flow down their concentration gradient into the neurons through the NSSs, thereby a
'/>"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. SNM releases new fact sheet on breast cancer and molecular imaging
2. Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
3. A new journal where molecular biology meets clinical research
4. Scientists trace molecular origin of proportional development
5. New molecular insight into vertebrate brain development
6. Plants display molecular amnesia
7. Pitt, NETL researchers report molecular chain reaction thought to be impossible
8. Tracking the molecular pathway to mixed-lineage leukemia
9. Researchers compile molecular manual for 100s of inherited diseases
10. Biologists learn structure, mechanism of powerful molecular motor in virus
11. Phoenix conference highlights TGens and Scottsdale Healthcares contributions to molecular oncology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... from the Wildlife Conservation Society shows that no-take ... valuable species such as lobster, conch, and fish ... nearby reef areas. , The reporttitled "Review of ... of research literature from no-take areas around the ... Dahlgren, a recognized expert in marine protected areas ...
(Date:7/11/2014)... 11, 2014--Researchers at the Department of Energy,s Oak ... awards, presented by R&D Magazine in recognition of ... awards recognize the tremendous value of our National ... and development at the National Labs continues to ... pursue the scientific and technological innovations necessary to ...
(Date:7/11/2014)... New South Wales, Australia when NASA,s Aqua satellite passed ... July 11 (12:35 p.m. local time/11:35 p.m. EDT on ... Wales (NSW), the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard ... spotted smoke (light brown) from various fires. Actively burning ... red. , The New South Wales, Australia Government website ...
Breaking Biology News(10 mins):Belize's lobster, conch, and fish populations rebuild in no-take zones 2ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4
... couches tested in a Duke University-led study contained potentially toxic or ... Among the chemicals detected was "Tris," a ... on animal studies. "Tris was phased out from ... risks, but it still showed up in 41 percent of the ...
... peer-reviewed study of the largest number of flame retardants ever ... at least one flame retardant that exceeded a federal health ... publish the study online on November 28, 12:01am Eastern. , ... for 49 flame retardant chemicals in household dust, the main ...
... motivations to serve their kids vegetables. A new Cornell ... simply serving vegetables with dinner, the main course would taste ... and attentive. , "Most parents know that vegetables are ... dinners," said lead author Brian Wansink, PhD, the John Dyson ...
Cached Biology News:Potentially toxic flame retardants found in many US couches 2New study: Many flame retardants in house dust -- unsafe levels 2New study: Many flame retardants in house dust -- unsafe levels 3
(Date:7/10/2014)... effect in bilayer graphene and shown that this exotic ... field. , The fractional quantum Hall effect, which ... exposed to large magnetic fields, is a striking example ... as a single system. However, while the basic theory ... this collective behavior remain not well understood, in part ...
(Date:7/10/2014)... can sit upside down forever. Nanophysics makes sure of that. ... article just published in Physical Review E . Knowledge ... spiders that seem to be able to sit still forever, ... many years. We will soon be able to buy smart ... foot. But the fact is, sooner or later the grip ...
(Date:7/10/2014)... by researchers at the University of Illinois at ... governing the interplay of spin and heat at ... ultrafast spintronic devices for data storage and information ... well as spin-angular momentum. In a typical charge ... no spin current," explained David Cahill, a professor ...
(Date:1/15/2014)... akin to assembling a club sandwich at the ... researchers have succeeded in crafting a uniform, multi-walled ... foam commonly used in upholstered furniture and other ... polyurethane foam was reduced 35 percent compared with ...
Breaking Biology Technology:Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3Even geckos can lose their grip 2University of Illinois study advances limits for ultrafast nano-devices 2Layered security: Carbon nanotubes promise improved flame-resistant coating 2
... Technology, Inc. announced today that Jim Bullock has been ... company.  Before joining Zyga Technology, Jim was President and ... Boston Scientific.  Prior to Atritech, Jim was President and ... St. Jude Medical.  (Logo: http://photos.prnewswire.com/prnh/20110118/CG30384LOGO ...
... BEIJING, January 16, 2012 Elsevier, ... information products and services, announced today that its ... management, NursingChina , is now available online. ... online reference product available in China, featuring skills ...
... in a wide variety of applications from food ... applications. Thermal analysis is routinely used to analyze ... to use nanostructured materials has made bulk techniques ... force microscope-based technique called nanoscale thermal analysis (nanoTA) ...
Cached Biology Technology:Zyga Technology, Inc. Announces the Appointment of Jim Bullock as President and CEO 2Elsevier Launches Bilingual International Nursing Skill Training and Management Platform: NursingChina.com 2Elsevier Launches Bilingual International Nursing Skill Training and Management Platform: NursingChina.com 3Magnetic actuation enables nanoscale thermal analysis 2
... Anti-NY-ESO-1, clone E978 ... NM_001327 Immunogen : ... Formulation: mouse ascites with ... Assurance: routinely evaluated by ...
Form: Ready to use Applications: Immunohistology-frozen, Immunohistology-paraffin, Western Blot, ELISA...
EnzChek Ultra Xylanase Assay Kit *500 assays*...
Defender against cell death 1...
Biology Products: