Navigation Links
Molecular interplay explains many immunodeficiencies
Date:11/11/2013

ee these effects in patients with X-linked severe combined immunodeficiency, whose impaired response to IL-21 causes severe antibody deficiency."

"Patients with mutations in the STAT3 gene develop Hyper IgE Syndrome, another rare immunodeficiency that manifests as compromised antibody production and greatly depleted immune defences."

Immunodeficiencies arising from mutations in single genes give scientists a unique opportunity to understand B cell signaling, and reveal potential targets for modulating B cell responses in immunodeficiency and autoimmunity.

The current study arose from analysing global gene expression in B cells from healthy people and people with STAT3 deficiency which immediately highlighted genes that were poorly expressed in disease. The Tangye lab plans to investigate other genes that impact the function of B cells.


'/>"/>

Contact: Alison Heather
a.heather@garvan.org.au
61-292-958-128
Garvan Institute of Medical Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. The Association for Molecular Pathology announces highlights of Phoenix meeting
2. Penn researchers identify molecular link between gut microbes and intestinal health
3. Singapore scientists expose molecular secrets of bile duct cancers from different countries
4. Molecular Velcro may lead to cost-effective alternatives to natural antibodies
5. Grafted limb cells acquire molecular fingerprint of new location, UCI study shows
6. Molecular biology: Designer of protein factories exposed
7. The molecular clock of the common buzzard
8. Cells molecular muscles help them sense and respond to their environments
9. Trovagene Announces Abstracts to be Presented at Molecular Targets and Cancer Therapeutics Conference
10. Recent highlights in Molecular Biology and Evolution
11. Better insight into molecular interactions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... are athletes who have suffered concussions ready to return ... found that high school athletes who head back on ... a significant regression in their abilities to simultaneously walk ... seen in changes in their balance and/or altered walking ... of the 12 had returned to activity in less ...
(Date:8/20/2014)... one day be made out of cocoa, rice and ... The novel process they developed and their results, which ... plastic waste problems, appear in the ACS journal ... colleagues at the Italian Institute of Technology point out ... production reached 288 million tons worldwide, but its ubiquity ...
(Date:8/20/2014)... have developed methods for electronically manipulating the flight muscles ... use to control those muscles. The work opens the ... for use in emergency response. , "In the big ... the movement of moths for use in applications such ... an assistant professor of electrical and computer engineering at ...
Breaking Biology News(10 mins):Recovery reversal seen in Oregon study of returning concussed athletes 2Recovery reversal seen in Oregon study of returning concussed athletes 3Research paves way for development of cyborg moth 'biobots' 2
... Research Institute is reporting a discovery that sheds light ... the normal processes that govern the everyday life of ... diseases, including cancer and septic shock. , The discovery ... their relationship to the genetic transcripts known as messenger ...
... to fathom a proverb ?catch the figurative meaning of "an ... research led by V. S. Ramachandran, director of the Center ... Diego, a region of the brain known as the angular ... ability to understand metaphor. , Ramachandran and colleagues tested four ...
... by a team of researchers at Penn State, which also ... to control tissue growth. The team's genetic and biochemical studies ... the journal Cell. "This discovery extends our understanding of how ... the formation of tumors, and it raises the possibility that ...
Cached Biology News:Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression 2Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression 3Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression 4Grasping metaphors: UC San Diego research ties brain area to figures of speech 2New tumor-suppressor gene discovered 2New tumor-suppressor gene discovered 3New tumor-suppressor gene discovered 4
(Date:8/20/2014)... An analysis of patented university inventions licensed to ... path to commercialization. To open these roadblocks, the ... results during the discovery stage could lead to ... are frequently derived from discoveries made in university ... well known during clinical trials, which have a ...
(Date:8/20/2014)... , Aug. 20, 2014  Decision Resources Group finds that ... Russia , India and ... billion in 2013, roughly equal to the size of ... the BRIC market will experience much faster growth as a result ... population. Other key findings from Decision Resources Group,s coverage ...
(Date:8/20/2014)... in your ear could improve the health of your ... University of Leeds used a standard TENS machine like ... pulses to the tragus, the small raised flap at ... the ear canal. , The stimulation changed the influence ... the nervous signals that can drive failing hearts too ...
(Date:8/19/2014)... and Markets  has announced the addition of the "Cell and ... their offering. This report analyzes the worldwide markets ... following Product Segments: Media, Sera, and Reagents. The report ... , Japan , Europe , ... . Annual estimates and forecasts are provided for the period 2013 ...
Breaking Biology Technology:Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 2BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 3'Tickling' your ear could be good for your heart 2Global Cell and Tissue Culture Supplies - Strategic Business Report 2014 2
... SAN DIEGO, Nov. 20 Veridiam (www.veridiam.com) won the ... the 2009 Workplace Excellence Awards. The awards are sponsored ... and recognize innovative and exceptional human resources practices. , ... than 129 employee-nominated companies, honored at the recent awards ...
... ... webinar, “Roller Compactions Process Optimization Using At-Line Particle Characterization”, will be presented on December ... demonstrated to map the design space and optimize a series of roller compaction runs ... ...
... Dr. Mate Hidvegi, inventor of Avemar fermented wheat germ extract, ... Biropharma Kft, discrediting the Hungarian company for making false and ... Dr. Hidvegi stated from his office in Budapest, Hungary: ... apply to AveULTRA, www.aveultra.com , is misleading. ...
Cached Biology Technology:Veridiam Wins Workplace Excellence Crystal Award in Mid-Size Company Category 2Roller Compaction Process Optimization Using At-Line Particle Characterization 2American BioSciences Rebuts Misleading Statements Made by Hungarian Competitor 2
... a group of enzymes involved in matrix ... metalloproteinase family ten exist in soluble form ... MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, ... domain anchoring them to the cell surface. ...
...
... IKATUBE ULTRA TURRAX Tube Disperser System from IKA ... It offers a cleaner, safer, and more efficient ... sample volumes from 2 to 15 ml inside ... can choose one of 4 different tube types. ...
...
Biology Products: