Navigation Links
Molecular hub links obesity, heart disease to high blood pressure
Date:4/11/2013

Obesity, heart disease, and high blood pressure (hypertension) are all related, but understanding the molecular pathways that underlie cause and effect is complicated.

A new University of Iowa study identifies a protein within certain brain cells as a communications hub for controlling blood pressure, and suggests that abnormal activation of this protein may be a mechanism that links cardiovascular disease and obesity to elevated blood pressure.

"Cardiovascular diseases are the leading cause of death worldwide, and hypertension is a major cardiovascular risk factor," says Kamal Rahmouni, Ph.D., UI associate professor of pharmacology and internal medicine, and senior study author. "Our study identifies the protein called mTORC1 in the hypothalamus as a key player in the control of blood pressure. Targeting mTORC1 pathways may, therefore, be a promising strategy for the management of cardiovascular risk factors."

The hypothalamus is a small region of the brain that is responsible for maintaining normal function for numerous bodily processes, including blood pressure, body temperature, and glucose levels. Signaling of mTORC1 protein in the hypothalamus has previously been shown to affect food intake and body weight.

The new study, which was published April 2 in the journal Cell Metabolism, shows that the mTORC1 protein is activated by small molecules and hormones that are associated with obesity and cardiovascular disease, and this activation leads to dramatic increases in blood pressure.

Leucine is an amino acid that we get from food, which is known to activate mTORC1. The UI researchers showed that activating mTORC1 in rat brains with leucine increased activity in the nerves that connect the brain to the kidney, an important organ in blood pressure control. The increased nerve activity was accompanied by a rise in blood pressure. Conversely, blocking this mTORC1 activation significantly blunted leucine's blood
'/>"/>

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-356-7124
University of Iowa Health Care
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
2. Beyond the microscope: Identifying specific cancers using molecular analysis
3. 2012 Forecast for US Molecular Diagnostics Market Now Available From Global Information Inc.
4. 5th Annual Advances in Biomolecular Engineering Symposium
5. PNAS: Precise molecular surgery in the plant genome
6. Molecular spectroscopy tracks living mammalian cells in real time as they differentiate
7. Hitting snooze on the molecular clock: Rabies evolves slower in hibernating bats
8. The activity of a bacterial effector protein seen in molecular detail
9. How bacteria change movement direction in response to oxygen: Molecular interactions unravelled
10. MARC travel award announced for the 2012 GSA Yeast Genetics and Molecular Biology Meeting
11. Highlighting molecular clues to the link between childhood maltreatment and later suicide
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... September 22, 2014The story of cowpea (black-eyed peas) is ... world,s biggest problemseven more fascinating is the story of ... wrote Cowpea: The Food Legume of the 21st Century ... management, and use. The book was recently published by ... International Institute of Tropical Agriculture (IITA). , Singh has ...
(Date:9/21/2014)... Diego, have developed a program that predicts the placement ... based on sequences of DNA. They describe their analysis ... cells in a paper published in Nature Methods ... have the same blueprint, the same DNA, although they ... the report. "Skin cells protect, nerve cells send signals, ...
(Date:9/21/2014)... previously thought, newborn immune T cells may have the ... to a new study led by King,s College London. ... of adults, babies may still be able to mount ... the journal Nature Medicine . , Our immune ... immune cells, including neutrophils which play an important role ...
Breaking Biology News(10 mins):Program predicts placement of chemical tags that control gene activity 2Immune system of newborn babies is stronger than previously thought 2
... Recently, academic debate has been swirling around the existence ... of phenomena, including photosynthesis, the process by which organisms ... suggested that entanglement (the quantum interconnection of two or ... separated in physical space) could be occurring in the ...
... operations to protect oil imports coming from the Middle ... than once thought, new research from the University of ... these emissions to U.S. gasoline use but they ... and Richard Perrin estimate that emissions of heat-trapping gases ...
... that eight of the most commonly used oil dispersants ... episode in the Gulf of Mexico, appear unlikely to ... interfere with reproduction, development, and other biological processes. The ... cytotoxicity (cell death), with JD-2000 and SAF-RON GOLD showing ...
Cached Biology News:Researchers: EPA should recognize environmental impact of protecting foreign oil 2
(Date:9/23/2014)... September 23, 2014 Healthcare ... globe will convene at the Society for ... be held October 26-28 in Houston, Texas ... and practice in individualized integrative cancer care. ... nurses, psychologists, nutritionists, naturopaths, acupuncturists, and other ...
(Date:9/22/2014)... MA (PRWEB) September 22, 2014 Pearl's ... scientific breakthrough in drought tolerant grass seed this week ... grass seed. The announcement coincides with the fact that ... the Spring as many believe. , As of ... rave and favorable reviews by industry experts and the ...
(Date:9/22/2014)... Platelets, the tiny cell fragments whose job it is ... a cell nucleus. But they can "feel" the physical ... have discovered. , Platelets respond to surfaces with greater ... they "turn on" other platelets and other components of ... smarter than we give them credit for, in that ...
(Date:9/22/2014)... a way to create a highly sensitive chemical sensor ... imperfections have unique electronic properties that the researchers were ... molecules by 300 times. , The study is available ... . , Amin Salehi- Khojin, asst professor of mechanical ... graduate student and Bijandra Kumar, post doc where they ...
Breaking Biology Technology:International Medical Experts to Discuss Latest Integrative Oncology Research and Its Translation to Personalized Clinical Care at 11th International Conference of SIO 2International Medical Experts to Discuss Latest Integrative Oncology Research and Its Translation to Personalized Clinical Care at 11th International Conference of SIO 3Pearl's Premium Ultra Low Maintenance Lawn Seed Announces A Major Breakthrough In Drought Tolerant Grass Seed 2Platelets modulate clotting behavior by 'feeling' their surroundings 2Graphene imperfections key to creating hypersensitive 'electronic nose' 2
... Hicks, president of the AFL-CIO in western Wisconsin, doesnt expect ... union hall these days. Theyre all working overtime handling the ... trains arriving from the coasts are full (with foreign-made goods), ... globalization, but Im told the returning trains are going back ...
... STI Knowledge, an Atlanta-based provider of business process ... with offices in Norristown, Pennsylvania; Scottsdale, Arizona; and ... its parent Symphony Corp. , ,Symphony Data is ... with a particular expertise in the provider, payors ...
... thoughtful ethical line with his decision to support one type ... to oppose another. Although the distinction made by Romney was ... define a more constructive debate over stem cell research in ... law in Wisconsin today, it wouldn't stop any current research ...
Cached Biology Technology:Trade deficit hits home in Wisconsin 2Trade deficit hits home in Wisconsin 3Massachusetts stem-cell plan reflects status quo for Wisconsin research 2Massachusetts stem-cell plan reflects status quo for Wisconsin research 3
Anti-human C5a/C5a des-Arg (neo-epitode), Clone 2952, Monoclonal Antibody...
...
Reacts with the 80 kDa fragment of the M-chain of human merosin....
Mouse anti-JNK (PT183/185) Class: Antibody Product Group: Signalling molecules and phospho-specific Antibody...
Biology Products: