Navigation Links
Molecular fossil
Date:11/14/2010

In today's world of sophisticated organisms proteins are the stars. They are the indispensible catalytic workhorses, carrying out the processes essential to life. But long, long ago ribonucleic acid (RNA) reigned supreme.

Now Northwestern University researchers have produced an atomic picture that shows how two of these very old molecules interact with each other. It is a rare glimpse of the transition from an ancient, RNA-based world to our present, protein-catalyst dominated world.

The scientists are the first to show the atomic details of how ribonuclease P (RNase P) recognizes, binds and cleaves transfer RNA (tRNA). They used the powerful X-rays produced by the Advanced Photon Source at Argonne National Laboratory to obtain images from crystals formed by these two RNA molecules. The result is a snapshot of one of the most complex models of a catalytic RNA and its target.

Details of the structure will be published Nov. 14 by the journal Nature.

"RNA is an ancient molecule, but it is pretty sophisticated," said Alfonso Mondragn, professor of molecular biosciences in the Weinberg College of Arts and Sciences. He led the research. "Our crystal structure shows that it has many of the properties we ascribe to modern molecules. RNA is a catalyst that has much of the versatility and complexity of modern-day proteins."

For billions of years and still to this day, the function of RNase P -- found in nearly all organisms, from bacteria to humans -- has been to cleave transfer tRNA. If the tRNA is not cleaved, it is not useful to the cell.

"We knew this important chemistry happened, that RNA acts as a catalyst, but we didn't know exactly how until now," Mondragn said. "We now have a better understanding of how RNA works."

RNase P is formed by a large RNA core plus a small protein, illustrating the evolutionary shift from an RNA world toward a protein-dominated world. The protein helps recognize the
'/>"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
Source:Eurekalert

Page: 1 2

Related biology news :

1. SNM releases new fact sheet on breast cancer and molecular imaging
2. Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
3. A new journal where molecular biology meets clinical research
4. Scientists trace molecular origin of proportional development
5. New molecular insight into vertebrate brain development
6. Plants display molecular amnesia
7. Pitt, NETL researchers report molecular chain reaction thought to be impossible
8. Tracking the molecular pathway to mixed-lineage leukemia
9. Researchers compile molecular manual for 100s of inherited diseases
10. Biologists learn structure, mechanism of powerful molecular motor in virus
11. Phoenix conference highlights TGens and Scottsdale Healthcares contributions to molecular oncology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... has shown that piglets can be weaned later with ... outcome of the study at the University,s Roseworthy campus, ... is an important finding for pig producers. It allows ... production. , "Sows don,t usually start their oestrous cycles ... piglets have been weaned," says Ms Alice Weaver, PhD ...
(Date:8/27/2014)... finds , Gamblers show the same tendencies as ... shown. , Researchers, led by Dr Elliot Ludvig of ... that found that both human gamblers and pigeons were ... rewards. , Published in Biology Letters , the ... role that memories of previous biggest wins and losses ...
(Date:8/26/2014)... Like a protective tent over a colony of ... infections especially difficult. Microorganisms protected in a biofilm ... antibiotic resistance and recalcitrance to treatment, and biofilm-protected ... bacterial infections in humans and are 50 to ... bacterial infections. , "In essence, we may have ...
Breaking Biology News(10 mins):Piglet weaning age no bar to litter frequency 2Gamblers are greedy bird-brains, University of Warwick research finds 2Breakthrough antibacterial approach could resolve serious skin infections 2Breakthrough antibacterial approach could resolve serious skin infections 3
... MARC (Maximizing Access to Research Careers) Program has announced ... Conferences held in July, 2013. These awards are meant ... and scientists into the mainstream of the basic science ... at the FASEB Science Research Conferences. This year MARC ...
... MARC (Maximizing Access to Research Careers) Program has announced ... Study of Reproduction meeting in Montreal, Canada from July ... entry of students, postdoctorates and scientists from underrepresented groups ... to encourage the participation of young scientists at the ...
... 2011 and 2012, research from China,s Nanjing University made ... of genetic material from the plants they,d ingested could ... animals, own genes off. The surprising results from Chen-Yu ... one day be treated with medicinal food, but also ...
Cached Biology News:Hold the medicinal lettuce 2Hold the medicinal lettuce 3
(Date:8/28/2014)... Boston, MA (PRWEB) August 28, 2014 ... of wholesale construction materials, selected SoundConnect ... of their cloud based audio and web conferencing ... configured to support PrimeSource’s employees’ needs. SoundConnect ... technologies. , PrimeSource Building Products will be ...
(Date:8/27/2014)... 2014 Green & Grow Inc. (GGI) ... funding and secured Otter Capital as a significant new ... commercialization of GGI’s Agriplier™ technology, building on recent compelling ... “Since our first meeting, we have been impressed with ... space,” said Alan Sobba, President and CEO of GGI. ...
(Date:8/27/2014)... Aug. 27, 2014   MSC , a healthcare ... today announced the appointment of Mary Beth Loesch ... 28 years of experience preparing companies for rapid growth ... Executive Vice President of Corporate Development and Healthcare. In ... business , as well as corporate strategy and marketing. ...
(Date:8/27/2014)... -- Research and Markets  has announced the ... Polymer, Food & Beverage, Personal Care & Pharmaceutical) ... report to their offering. Lactic acid ... carbon atom. The main applications of lactic acid ... personal care product, and pharmaceutical industries. Lactic ...
Breaking Biology Technology:PrimeSource Chooses SoundConnect as Collaboration Provider 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3MSC names Mary Beth Loesch President and CEO 2Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2
... Health Care Forum discusses the future of Continuing ... ... Accredited online nursing courses,are replacing traditional classroom-based courses, offering nurses ... options., Ann Johnson, CEO of Wild Iris Medical Education took ...
... 2 Simbionix has announced the,release of a ... simulator that,gives trainees hands-on experience with different techniques ... tubal,sterilization and oophorectomy., The GYN module is ... developed for the LAP Mentor, the world,s most ...
... Japan and UNION CITY, Calif., June 2 ... that the two,companies have entered into a research ... and Asian development and,commercialization of sirolimus for the ... related macular degeneration (wet AMD) and,diabetic macular edema ...
Cached Biology Technology:Modernizing Continuing Education With Online Courses 2Simbionix Takes Non-Invasive GYN Surgical Training to the Next Level 2Santen and MacuSight Announce Collaboration and License Agreement for Sirolimus in Ocular Diseases and Conditions 2Santen and MacuSight Announce Collaboration and License Agreement for Sirolimus in Ocular Diseases and Conditions 3
Rat Antibody to Mouse TCR VB8.1,8.2:FITC Recognises the V beta 8.1 and V beta 8.2 determinants of the murine T cell receptor. Specificity: mouse TCR VB8.1 and 8.2...
fli-1...
Vesicle Associated Membrane Protein (VAMP 1/2)...
Anti-Mouse Valpha 2 TCR, Purified (Clone B20.1) (rat IgG2a)...
Biology Products: