Navigation Links
Molecular forces are key to proper cell division
Date:1/21/2013

AMHERST, Mass. Studies led by cell biologist Thomas Maresca at the University of Massachusetts Amherst are revealing new details about a molecular surveillance system that helps detect and correct errors in cell division that can lead to cell death or human diseases. Findings are reported in the current issue of the Journal of Cell Biology.

The purpose of cell division is to evenly distribute the genome between two daughter cells. To achieve this, every chromosome must properly interact with a football-shaped structure called the spindle. However, interaction errors between the chromosomes and spindle during division are amazingly common, occurring in 86 to 90 percent of chromosomes, says Maresca, an expert in mitosis.

"This is not quite so surprising when you realize that every single one of the 46 chromosomes has to get into perfect position every time a cell divides," he notes. The key to flawless cell division is to correct dangerous interactions before the cell splits in two.

Working with fruit fly tissue culture cells, Maresca and graduate students Stuart Cane and Anna Ye have developed a way to watch and record images of the key players in cell division including microtubule filaments that form the mitotic spindle and sites called kinetochores that mediate chromosome-microtubule interactions. They also examined the contribution of a force generated by molecular engines called the polar ejection force (PEF), which is thought to help line up the chromosomes in the middle of the spindle for division. For the first time, they directly tested and quantified how PEF, in particular, influences tension at kinetochores and affects error correction in mitosis.

"We also now have a powerful new assay to get at how this tension regulates kinetochore-microtubule interactions," Maresca adds. "We knew forces and tension regulated this process, but we didn't understand exactly how. With the new technique, we can start to d
'/>"/>

Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. La Jolla Institute identifies molecular switch enabling immune cells to better fight disease
2. Molecular 2-way radio directs nerve cell branching and connectivity
3. Scientists pinpoint molecular signals that make some women prone to miscarriage
4. Webcast alert: Molecular Medicine Institute to give new hope to pediatric patients
5. Discovery of molecular pathway of Alzheimers disease reveals new drug targets
6. Ah, that new car smell: NASA technology protects spacecraft from outgassed molecular contaminants
7. New Market Forecasts Available for Critical Global Biotechnology Testing and Screening Markets: Molecular Diagnostics, Hematology, Clinical Chemistry and Nucleic Acid Testing
8. Researchers describe new molecular interactions behind the inhibition of TGF beta-signaling
9. Molecular movies may accelerate anti-cancer drug discovery
10. Molecular and protein markers discovered for liver transplant failure from hepatitis C
11. Molecular economics: New computer models calculate systems-wide costs of gene expression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecular forces are key to proper cell division
(Date:12/15/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/87pph8/global_facial ) ... Facial Recognition Market 2015-2019" report to their ... Facial recognition is a technology used ... measures the overall facial feature of a person ... distance between eyes. Facial recognition is used for ...
(Date:12/11/2014)... -- That blood pressure plays a role in human health has ... term for high blood pressure – was first described as ... that,s used in measuring blood pressure was invented in 1896. ... hypertension, its triggers and its effects. In fact, recent findings ... best ways to treat it. For example, a ...
(Date:12/10/2014)... , Dec. 9, 2014  Valencell, a leader in ... seeing a staggering demand from its licensees for highly ... revealed, is not solely coming from fitness and health ... "A wearable is only as useful as ... is the ultimate driver in long-term mass consumer adoption ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4Wearable Technology Products Demand Highly Accurate Biometric Technology 2
... amounts, it can make teeth stronger and aid in the ... can be a killer a carcinogen that causes bone, ... additive in most American communities, drinking water and an ingredient ... Determining the level of fluoride, be it in water, consumer ...
... and heart attacks have been found to share common genetic ... test on developing the risk of the diseases even at ... the University of Bologna who coordinated the study published in ... test is now ready. "They are already selling it in ...
... at Virginia Tech have discovered some of the key ... inflammatory bowel disease. The results, which help researchers move ... drugs to treat inflammatory and immune-mediated diseases, are reported ... the journal Mucosal Immunology from the Nature ...
Cached Biology News:Researcher develops accurate method for detecting dangerous fluoride 2Researcher develops accurate method for detecting dangerous fluoride 3Researcher develops accurate method for detecting dangerous fluoride 4Medicine: Alzheimer's and heart attacks share the same genes 2Medicine: Alzheimer's and heart attacks share the same genes 3Immune system changes linked to inflammatory bowel disease revealed 2Immune system changes linked to inflammatory bowel disease revealed 3
(Date:12/19/2014)... , Dec. 18, 2014  Decision Resources Group finds ... biomaterial market will grow moderately through 2023 as the ... growing awareness of dental biomaterials all spur procedure volumes. ... as China and ... dental procedures within reach for a larger proportion of ...
(Date:12/19/2014)... 18, 2014   ISN has released its ... Indicators publication series. With data aggregated from ... in 2013 within its online contractor management platform, ISNetworld, ... performance indicator (KPI) statistics. The ... publication is available in two industry specific volumes: ...
(Date:12/17/2014)... 16, 2014 The Activated Carbon ... which is why IBISWorld updated its original industry research ... benefit from an intensified focus on environmental policy. Over ... emission standards for power plants and a range of ... IBISWorld Industry Analyst Sarah Kahn, “a range of downstream ...
(Date:12/17/2014)... USA (PRWEB) December 16, 2014 ... manager at Philipps- Universität Marburg’s Department of Physics, ... photonics, in the newly released SPIE Women ... never be too shy to ask questions.” , ... technology, engineering, and mathematics) occupations ranging from university ...
Breaking Biology Technology:Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 3ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 2Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 3Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 3
... 3 tropical storm that struck the low-lying and heavily populated coastline ... of the U.S. Department of Agriculture (USDA) began producing a series ... to accompany its commodity intelligence reports. , ... Redlands, ...
... Bio-Pharma Solutions, Inc.,(ABS), a global provider of ... is pleased to announce that Nandini,Hadker, an ... been promoted to,Executive Director and will oversee ... has been appointed,President & CEO of the ...
... Inc., an,acute care specialty pharmaceutical company, today announced the,appointment ... a key senior,executive to the company,s management team. Gary ... biopharmaceutical executive with more than,30 years of experience. Dr. ... the founder and past Chairman and CEO of QRx ...
Cached Biology Technology:Myanmar's Cyclone-Damaged Rice Production Regions Monitored with GIS 2Myanmar's Cyclone-Damaged Rice Production Regions Monitored with GIS 3Abt Bio-Pharma Solutions, Inc. Names Nandini Hadker as Executive Director, Succeeding Susan Windham-Bannister 2Abt Bio-Pharma Solutions, Inc. Names Nandini Hadker as Executive Director, Succeeding Susan Windham-Bannister 3Pacira Pharmaceuticals, Inc. Adds Board Member and Key Senior Management 2
... containing Dermal Fibroblasts (Mouse/BalbC) and media. This ... culture, and is guaranteed to provide an ... the date supplied, when used with the ... day 18.5 ,Applications: ,Cultivation: Plate ...
... designed for protein pull-down experiments ... binding proteins. An order of ... agarose beads with 10 nmol ... terminus of the alkyl chain; ...
Rabbit polyclonal to Staphylococcus Enterotoxin A (HRP) ( Abpromise for all tested applications)....
... Novexin offers bespoke, cost-effective solutions for complex protein processing ... expertise and experience to help you develop a solution ... , ... transfer all methodology to ...
Biology Products: