Navigation Links
Molecular chaperones traffic signaling proteins between cells in plant stem-cell maintenance pathway
Date:8/26/2011

isted and folded into very specific conformations. Since changes in protein function are related to changes in structure, it is not surprising that chaperonins, members of a larger class of folding machines called chaperones, are ubiquitous in living things.

Once Jackson's team had proven the necessity of chaperonins in KN1 trafficking, they set their sights on revealing the "how" and "why" of the relationship. In a series of experiments involving maize and Arabidopsis, a mustard plant used widely as a model for genetics research, they confirmed, first, that the entire chaperonin machinery a protein mega-complex consisting of eight segments, or subunits is involved in cell-to-cell trafficking of KN1.

"We could then ask questions about the mechanism involved, and about the functional importance of this trafficking to the plants," says Jackson. Through an ingenious process of elimination, he and his colleagues performed experiments showing that a portion of the chaperonin complex, called CCT8, had to be present in the "destination" cell if KN1 trafficking was to occur normally. "We inferred from our results that the chaperonin performs its role in the trafficking by refolding KN1 proteins in the destination cell. In other words, KN1 travels through the channel in a partly unfolded state."

Even more important, the team concluded that by selectively transporting KN1 and other "mobile signals" using this mechanism, plants are able to establish and maintain populations of stem cells. As Jackson's prior work has shown, this occurs, for instance, in meristems, the stem cell-rich tips of plants where new growth takes place.

Why do the signals that maintain stem cells need to be mobile? "Development is all about communication," Jackson explains. "Cells talk to each other, among other things, to influence one another. We hypothesize that the trafficking of signals like KN1 could serve to establish protein concentration gradient
'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Penn molecular scientists develop color-changing stress sensor
2. Carnegie Mellon scientists discover how molecular motors go into energy save mode
3. Pitt team finds molecular pathway that leads to inflammation in asthma
4. Handbook of Molecular Microbial Ecology: Exploring the World of the Microbes
5. RUB researchers decipher the molecular basis of blue-green algae
6. Common drugs initiate a molecular pas de quatre at the surface of the cell membrane
7. Breaking the chain: Molecular cap blocks processes that lead to Alzheimers, HIV
8. Plant pathologist finding Kansas wheat fields a molecular battleground this season
9. Team solves decades-old molecular mystery linked to blood clotting
10. Molecular technique advances soybean rust resistance research
11. Several baffling puzzles in protein molecular structure solved with new method
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... the Volunteer Wildfire Services of South Africa as "Cape ... residents in certain parts of the province on Monday ... high veld fire danger rating is expected in the ... Kei and Mnquma area. Strong winds often occurred ... bring lightning strikes and subsequent fire and the wind ...
(Date:8/27/2014)... -- The IEEE Engineering in Medicine and Biology Society ... Conference (EMBC,14), this year being held at the Sheraton ... , from Tuesday, August 26 through Saturday, August ... professionals in science, medicine, and engineering are registered to ... This year,s conference theme is Discovering, ...
(Date:8/27/2014)... frightening beasts. But every creature is a baby once. ... fossils of 24 very young dinosaurs and one older ... by a caretaker, according to a new study by ... and Peter Dodson led the work, collaborating with researchers ... specimen is held. Hedrick is a doctoral student in ...
Breaking Biology News(10 mins):Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 2Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 3Penn paleontologists describe a possible dinosaur nest and young 'babysitter' 2Penn paleontologists describe a possible dinosaur nest and young 'babysitter' 3
... in humanity,s greatest achievements but scientists have found that working ... chimpanzees. A series of trials by scientists found ... also understand the need to help a partner perform their ... were given tools to get grapes out of a box. ...
... known risk factor for back pain and disc disease. ... Annual Meeting of the American Academy of Orthopaedic Surgeons ... in 6,779 patients undergoing treatment for spinal disorders with ... each patient,s age, gender, weight, smoking history, assessment of ...
... Stingrays living in one of the world,s most famous ... the Cayman Islands have profoundly changed their ways, ... on marine wildlife, reports a new study published March ... Researchers from Nova Southeastern University,s Guy Harvey Research ...
Cached Biology News:Origins of human teamwork found in chimpanzees 2Origins of human teamwork found in chimpanzees 3Tourist-fed stingrays change their ways 2
(Date:8/27/2014)... Aug. 27, 2014  A novel biomarker for ... physicians better identify early-stage disease, when treatment can ... to a new study in The Journal of ... DGX ) and other institutions found ... outperformed conventional antibody-serum testing, including rheumatoid factor (RF) ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 “We are ... technology vendors,” said Ven Thangaraj, CEO of Radiant Sage. ... that are taking the imaging corelab market to a ... corelabs and research organizations to efficiently and effectively manage ... the data to be analyzed and read by trained ...
(Date:8/27/2014)... , Aug. 27, 2014 Guggenheim Securities, the ... today announced the hiring of veteran equity analyst Charles ... analyst. Mr. Butler will focus on the biotech/biopharma sector. ... a wealth of experience and a broad network of ... Senior Managing Director and Head of Equities at Guggenheim ...
(Date:8/27/2014)... -- Reportbuyer.com has added a new market research ... Rational View https://www.reportbuyer.com/product/1595336/The-Graphene-Opportunity---A-Rational-View.html ... similar amount of hype currently surrounds graphene, with ... water treatment, but is graphene the only solution? ... Opportunity Report, authored by Tim Harper ...
Breaking Biology Technology:Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4Radiant Sage Named to CIOReview List of 100 Most Promising Technology Companies 2Guggenheim Securities Hires Analyst Charles "Tony" Butler to Expand Healthcare Coverage 2The Graphene Opportunity - A Rational View 2The Graphene Opportunity - A Rational View 3The Graphene Opportunity - A Rational View 4
... 11 Zimmer Holdings, Inc.,(NYSE: ZMH ; SWX: ... Blair & Company 28th Annual Growth Stock Conference in ... Time., A live webcast of the presentation can ... . The webcast will,be archived for replay following ...
... N.J., June 11 Veridex, LLC announced,today that it ... of the assets of Immunicon Corporation (OTC Bulletin,Board: IMMC) ... date,adjustments, plus the discharge and release of certain claims ... liabilities., The assets to be acquired include intellectual ...
... recognized in premier program ... for the medical technology community, ... the company,s RealHand High Dexterity (HD) instruments were,recognized with ... an excellent job thinking ,outside of the box, to ...
Cached Biology Technology:Veridex Announces Agreement to Acquire the Assets of Immunicon Corporation 2Novare Surgical Wins Medical Design Excellence Award 2
...
More cell-permeant than acridine orange....
Anti-rat Ig HRP detection kit...
One bottle containing 30 ml of protein solution and 0.1% sodium azide....
Biology Products: