Navigation Links
Molecular chaperone keeps bacterial proteins from slow-dancing to destruction
Date:12/28/2009

ANN ARBOR, Mich.---Just like teenagers at a prom, proteins are tended by chaperones whose job it is to prevent unwanted interactions among immature clients. And at the molecular level, just as at the high school gym level, it's a job that usually requires a lot of energy.

In new research, scientists at the University of Michigan and Howard Hughes Medical Institute have discovered how a protein chaperone called HdeA, which helps protect bacteria like the notorious Escherichia coli from the ravages of stomach acid, saves energy while keeping proteins from forming destructive clumps.

The research is described in a paper published online this week in the Proceedings of the National Academy of Sciences.

Proteins in disease-causing bacteria like E. coli unfold when they land in stomach acid after being accidentally ingested by humans and other animals. This unfolding stops the proteins from working and could spell doom for the bacteria if the chaperone HdeA didn't step in. HdeA works by binding very tightly to the unfolded proteins while the bacteria are in the stomach. By attaching to the bacterial proteins, the chaperone stops them from tangling like slow-dancing teens, which could kill the bacteria.

The researchers discovered how HdeA is then able to let go of the unfolded proteins as the bacteria pass into the small intestine so that the proteins refold instead of clumping together.

"HdeA uses a unique timed-release mechanism," said postdoctoral fellow Tim Tapley, who spearheaded the work. "If the proteins were released all at once they would likely clump together, killing the bacteria. What we found instead is that the chaperone HdeA lets go of them gradually, making it more likely that they fold back up into their proper form than clump together."

While most molecular chaperones consume large amounts of cellular energy in order to function, HdeA instead taps energy freely available in its living en
'/>"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
Source:Eurekalert

Page: 1 2

Related biology news :

1. New molecular regulators of hyperthyroidism and goiter
2. Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
3. UC health news: molecular pathway may predict chemotherapy effectiveness
4. New molecular clock from LLNL and CDC indicates smallpox evolved earlier than believed
5. Story ideas from Molecular & Cellular Proteomics
6. Lets talk -- new paradigms in the research of the biomolecular composition of water
7. Scientists unveil structure of molecular target of many drugs
8. Potential new therapeutic molecular target to fight cancer
9. NIH selects LIAI for major study on allergy molecular causes and possible treatments
10. Pennsylvania Hospital surgeon receives grant to develop molecular cardiac surgery
11. Leading cause of death in preemies might be controlled by resetting a molecular switch
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/1/2015)... Conn. , Apr. 1, 2015  NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... of Wocket smart wallets is underway to early access ... access group includes usage at retail outlets including Walmart, ... Pharmacy. Users report Wocket was accepted at all outlets ...
(Date:3/26/2015)... The Granite Club, Canada,s ... announced it has implemented a state-of-the-art access and security ... and staff, while restricting access to authorized users only. ... IMID Access system because it has the perfect combination ... in addition to unparalleled security," said James DiRenzo ...
(Date:3/23/2015)... 2015 SoundView Technology Group issues a new research ... ) Wocket smart wallet. SoundView was one of the selected user ... with the Wocket in multiple scenarios and outlets. ... other retailers, making both debit and credit card payments.  ... "If the company meets their plans in 2015, it would ...
Breaking Biology News(10 mins):NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4
... in cities have a smaller carbon footprint than people who ... analysis than in the past, scientists at Aalto University in ... same in the city and in the rural areas. More ... change are dependent upon how much goods and services people ...
... 2011 Highlights: ... the air Radio was integrated easily with Army,s cellular ... video to smartphones Harris Corporation,s (NYSE: ... wideband communications network infrastructure for various mission scenarios at the ...
... After being hunted to local extinction more than a century ... southern right whales of mainland New Zealand are coming home. ... first time that whales from a small surviving population around ... New Zealand mainland. Before the onslaught of 19th century ...
Cached Biology News:City dwellers produce as much CO2 as countryside people do 2Harris Corporation's Highband Networking Radio Provides Mobile, Wideband Communications for Empire Challenge 2011 2Harris Corporation's Highband Networking Radio Provides Mobile, Wideband Communications for Empire Challenge 2011 3Fighting back from extinction, New Zealand right whale is returning home 2Fighting back from extinction, New Zealand right whale is returning home 3
(Date:5/5/2015)... May 5, 2015 CytomX, a biotechnology company ... announced that Sean McCarthy , D. Phil., chief ... Day in New York at ... will present an overview of CytomX,s Probody pipeline, including ... programs. About CytomX Therapeutics CytomX Therapeutics ...
(Date:5/5/2015)... DIEGO , May 5, 2015   ... announced that David R. Parkinson , M.D., ... has been appointed to the board of directors ... years of experience in oncology clinical development, including ... resulted in global approvals of the cancer therapeutics ...
(Date:5/5/2015)... (PRWEB) May 05, 2015 GEA ... last week as recipients of the INTERPHEX Exhibitor ... recognition of their Portable, Continuous, Miniature and Modular ... a small footprint, continuous processing equipment, smart control ... process API powders and inactive ingredients into bulk ...
(Date:5/5/2015)... Synedgen Inc. is pleased to announce the ... , Dr. Nguyen brings to Synedgen critical regulatory expertise ... as it moves forward in the FDA regulatory processes ... years. Dr. Nguyen will lead the management of nonclinical ... that must be completed in order to initiate human ...
Breaking Biology Technology:Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 2Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 3Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 4GEA Pharma Systems, G-CON Manufacturing and Pfizer Consortium Receives Best Technology Innovation Award at INTERPHEX 2015 2GEA Pharma Systems, G-CON Manufacturing and Pfizer Consortium Receives Best Technology Innovation Award at INTERPHEX 2015 3Synedgen Announces the Appointment of Regulatory Affairs Manager 2
... March 11, 2011 Verenium Corporation (Nasdaq: ... the development and commercialization of high-performance enzymes, today announced ... its outstanding convertible notes in a series of privately-negotiated ... Company repurchased $19.9 million in principal amount of its ...
... Nanotech consumer products continue to grow at ... Project on Emerging Nanotechnologies (PEN) over 1,300 manufacturer-identified, ... the world. The most recent update to the ... the tiny particles in everything from conventional products ...
... March 10, 2011 Advanced Cell Technology, Inc. (“ACT”; ... in the field of regenerative medicine, announced today that ... European Medicines Agency (EMA) has announced a positive opinion ... epithelial (RPE) cells for designation as an orphan medicinal ...
Cached Biology Technology:Verenium Announces Debt Repurchase 2Verenium Announces Debt Repurchase 3ACT Receives Positive Opinion for Orphan Drug Designation from European Medicines Agency for hESC-Derived RPE Cells for Treatment of Stargardt's Disease 2ACT Receives Positive Opinion for Orphan Drug Designation from European Medicines Agency for hESC-Derived RPE Cells for Treatment of Stargardt's Disease 3
Rabbit polyclonal to UBC12 (rating: ****) ( Abpromise for all tested applications). Antigen: Synthetic peptide: RGGYIGSTYFER, corresponding to amino acids 169-180 of UBC12 Entrez Gene ID: 90...
GBL Antibody...
...
... Well BAC Prep; Ideal for ... 1.5ml 2xYT cultures; Provides high-quality ... sequencing for small to large ... which minimizes shearing and improves ...
Biology Products: