Navigation Links
Molecular basis identified for tissue specific immune regulation in the eye and kidney
Date:2/20/2013

Both AMD, which affects around 50 million people worldwide, and aHUS, a rare kidney disease that affects children, are associated with incorrectly controlled immune systems. A protein called complement factor H (CFH) is responsible for regulating part of our immune system called the complement cascade. Genetic alterations in CFH have been shown to increase a person's risk of developing either AMD or aHUS, but rarely both. Why this is the case has never been explained until now.

Researchers from the Wellcome Trust Centre for Cell Matrix Research and the Ophthalmology and Vision Research Group in The University of Manchester's Institute of Human Development have been expanding on their previous work that demonstrated a single common genetic alteration in CFH prevents it from fully protecting the back of the human eye. The research teams of Professor Tony Day and Professor Paul Bishop found that a common genetically altered form of CFH associated with AMD couldn't bind properly to a layer under the retina called Bruch's membrane. Having a reduced amount of CFH in this part of the eye leads to low-level inflammation and tissue damage, eventually resulting in AMD.

However, this mutation that changes CFH function in the eye has no affect on the protein's ability to regulate the immune system in the kidney. A cluster of genetic mutations in a completely different part of CFH are associated with the kidney disease aHUS, but these have no affect on the eyes.

In their most recent study, which was funded by the Medical Research Council and published in the Journal of Immunology, the Manchester researchers have identified why these mutations in CFH result in diseases in very specific tissues. Professor Day explains: "For the first time we've been able to identify why these protein mutations are so tissue specific. We're hoping our discovery will open the door to the development of tissue specific treatments to help the millions of people
'/>"/>

Contact: Morwenna Grills
Morwenna.Grills@manchester.ac.uk
44-161-275-2111
University of Manchester
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Explosive breakthrough in research on molecular recognition
2. Mainz scientists confirm original tetrahedral model of the molecular structure of water
3. FASEB SRC announces: Molecular Mechanisms & Physiological Consequences of Protein Aggregation
4. FASEB SRC announces conference registration open for: Ciliate Molecular Biology
5. Elsevier launches new open access journal: Molecular Metabolism
6. Virginia Tech computer scientists develop new way to study molecular networks
7. Molecular forces are key to proper cell division
8. La Jolla Institute identifies molecular switch enabling immune cells to better fight disease
9. Molecular 2-way radio directs nerve cell branching and connectivity
10. Scientists pinpoint molecular signals that make some women prone to miscarriage
11. Webcast alert: Molecular Medicine Institute to give new hope to pediatric patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... coal for domestic heating may contribute to early fetal ... The Saban Research Institute of Children,s Hospital Los Angeles ... the world. , In a paper published today in ... report ,"alarmingly strong statistical correlations" between seasonal ambient air ... , UB has one of the highest levels of ...
(Date:4/23/2014)... in French and Spanish . ... 2014Today, the CEC released its Conservation Assessment for the ... Conservation, which identifies 29 priority conservation areas in a ... different protected areas in the states of Texas, Coahuila, ... and semi-arid habitats inhabited by rare and endangered plants ...
(Date:4/23/2014)... accurate group decision increases with the abundance of brains ... a variety of factors as often happens in ... smaller groups actually tend to make more accurate decisions ... certain pieces of information. , The findings present a ... or the "wisdom of crowds," wherein individual observations ...
Breaking Biology News(10 mins):Pollutants from coal-burning stoves strongly associated with miscarriages in Mongolia 2Conservation priorities released for several protected areas along US-Mexico border 2Conservation priorities released for several protected areas along US-Mexico border 3Too many chefs: Smaller groups exhibit more accurate decision-making 2Too many chefs: Smaller groups exhibit more accurate decision-making 3
... mother,s diet during gestation and lactation were found to be ... those not exposed to the chemical, researchers at the University ... is a chemical most commonly found in the lining of ... many hard plastic bottles, including baby bottles, but many companies ...
... Conn.Like organisms, cities need energy, water, and nutrients, and ... ways that are viable and sustainable over the long ... for looking systematically at the resources that flow into ... from themto understand the environmental impacts of cities and ...
... 2013 UC Irvine neuroscientists have developed a way ... a novel opportunity to treat the most severe manifestations ... of temporal lobe epilepsy, Ivan Soltesz, Chancellor,s Professor and ... EEG-based computer system that activates hair-thin optical strands implanted ...
Cached Biology News:Female mice exposed to BPA by mothers show unexpected characteristics 2Female mice exposed to BPA by mothers show unexpected characteristics 3Urban metabolism for the urban century 2
(Date:1/15/2014)... 2014  Bill Jacobs Automotive, a group of car dealerships headquartered ... the Heartland Blood Center and offering free oil change coupons ... place Saturday, Jan. 18 at the Bill Jacobs Cadillac and ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The Bill Jacobs ...
(Date:1/15/2014)... 2014   Niagara Thermal Products is proud to ... Technologies LLC ("B3") as the critical thermal component supplier ... the Army Corps of Engineers.  B3 has developed the ... contaminants and destroys VOCs and other chemical pollutants, allergens ...
(Date:1/15/2014)... Village, Calif. (PRWEB) January 15, 2014 ... treatment and management through the genomic analysis of tumor ... offer Therapy Finder™, a web-based cancer decision support application ... reporting option with Cynvenio’s ClearID™ genomic test, Therapy Finder ...
(Date:1/15/2014)... ­ RedBrick Health , a fast-growing leader in ... that EmblemHealth , the New York ... providing the RedBrick Compass health assessment, combined with the ... its members. EmblemHealth is among the first health plans ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3
... In the quest to exploit unique properties at ... have developed a novel technique for creating uniform ... and students in the Department of Physics and ... methods from holographic lithography to demonstrate a new ...
... Pharmaceuticals, Inc. (NASDAQ: IDIX ), announced today that ... Stanley Global Healthcare Conference on September 13 at 8:35 a.m. ... the Bank of America Merrill Lynch Global Healthcare Conference on ... of America Merrill Lynch Financial Centre, London.   ...
... Cellectis (Alternext: ALCLS), the French genome engineering specialist, will present at ... September 20, 2011, and at the MidCap Event in Paris on ... will present the activities and the development strategy of the Cellectis ... Hyatt New York hotel on Tuesday, September 20, 2011 at 11:30 ...
Cached Biology Technology:Stevens researchers pioneer novel technique to make plasmonic nanogap arrays 2Stevens researchers pioneer novel technique to make plasmonic nanogap arrays 3
RABBIT ANTI ISOCITRATE DEHYDROGENASE...
... two highly efficient methods of identifying recombinant ... By using the large-scale screen method in ... is to transfer partial colonies of E. ... into the solutions provided by the kits ...
Recombinant Rat Leptin, CF...
Rat whole blood (Sprague-Dawley, averaging 7-8 weeks of age, either sex) is collected at the time of slaughter and refrigerated within 6 hours, and processed and frozen within 24 hours. The serum is ...
Biology Products: