Navigation Links
Molecular basis for neurodegeneration in Ataxia telangiectasia
Date:4/14/2008

An upcoming paper from Dr. David Wassarman (University of Wisconsin School of Medicine and Public Health) in the May 1 issue of G&D lends new insight into the pathogenesis of neurodegeneration in Ataxia telangiectasia.

Ataxia telangiectasia (A-T) is a rare, genetic immunodeficiency disease that affects multiple organ systems and is characterized by neurodegeneration and cancer predisposition. A-T is caused by recessive mutations in the ataxia telangiectasia mutated (ATM) gene.

While existing animal models have established how ATM mutations contribute to genomic instability and cancer susceptibility, Dr. Wassarmans paper reveals how ATM mutations cause neurodegeneration.

The scientists generated a Drosophila model of A-T, in which neurodeneneration occurs in the absence of induced DNA damage as it does in human A-T patients. Thus, Dr. Wassarmans model most faithfully recapitulates neurodegeneration associated with the human disease.

Using this model, Dr. Wassarman and colleagues determined ATM functions normally to prevent neurons from re-entering the cell cycle.

At the end of the day, ATM-dependent arrest of cell growth is critical for both neuron function and tumor suppression, explains Dr. Wassarman. Furthermore, he is excited by the findings, as they point to possible therapeutic potential of CDC25 and other cell cycle inhibitors to treat A-T as well as other neurodegenerative disorders.


'/>"/>

Contact: Heather Cosel-Pieper
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1

Related biology news :

1. ESF conference probes waters mysterious interactions at molecular level
2. Power of molecular imaging reveals secrets of the heart
3. Computer simulations point to key molecular basis of cystic fibrosis
4. New edition of a classic molecular biology textbook from CSHL Press and Benjamin Cummings
5. Molecular Biology of the Cell celebrates 25 years of publication
6. Shilatifard Lab sheds light on molecular machinery required for translation of histone crosstalk
7. How molecular muscles help cells divide
8. Leading cause of death in preemies might be controlled by resetting a molecular switch
9. Pennsylvania Hospital surgeon receives grant to develop molecular cardiac surgery
10. NIH selects LIAI for major study on allergy molecular causes and possible treatments
11. Potential new therapeutic molecular target to fight cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... April 5, 2017 Today HYPR Corp. ... the server component of the HYPR platform is officially ... the end-to-end security architecture that empowers biometric authentication across ... has already secured over 15 million users across the ... of connected home product suites and physical access represent ...
(Date:3/30/2017)...  On April 6-7, 2017, Sequencing.com will host the ... hackathon at Microsoft,s headquarters in Redmond, Washington ... developing health and wellness apps that provide a unique, ... is the first hackathon for personal genomics and ... in the genomics, tech and health industries are sending ...
(Date:3/28/2017)... 28, 2017 The report "Video ... Monitors, Servers, Storage Devices), Software (Video Analytics, VMS), and ... Global Forecast to 2022", published by MarketsandMarkets, the market ... is projected to reach USD 75.64 Billion by 2022, ... The base year considered for the study is 2016 ...
Breaking Biology News(10 mins):
(Date:5/24/2017)... As Ebola resurfaces in the Democratic Republic of ... now reported, a new analysis of the Ebola gene polymerase ... the 2014 and 2017 outbreaks of the disease.  ... preceded the 2014 outbreak. An analysis of the latest data ... 2014-15, which again precedes the current outbreak in the DRC. ...
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... ... celebrates this month its 20th anniversary, marking the occasion with a strong presence ... the meeting’s Welcome Reception and further extends an invitation to all attendees to ...
(Date:5/23/2017)... ... 23, 2017 , ... Energetiq Technology, a world leader in ... to accommodate its rapid growth. , The renovations at the company’s headquarters in ... existing areas. The expansion includes, a state-of-the-art engineering facility, and a second clean ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... re-engineer their control technology again and again. METTLER TOLEDO has released two new ... The videos illustrate how integration of the ACT350 into Siemens and Allen Bradley ...
Breaking Biology Technology: