Navigation Links
Molecular and protein markers discovered for liver transplant failure from hepatitis C
Date:8/16/2012

to tailor treatment to the individual patient.

Rasmussen said that, at present, liver patients regularly have invasive core-needle biopsies to check their transplanted liver. Strong antiviral drugs are available to try to offset hepatitis C liver damage, she explained, but these are not always effective and usually have harsh side effects. Surgeons have been hoping for a test that could indicate if a patient was likely to do well with less aggressive treatment. This knowledge might spare the patient from unnecessary repeat biopsies and the most potent antiviral regimens, which impose severe, flu-like discomfort, chronic fatigue, depression and anemia.

She added that the discovery of the protein and molecular markers of hepatitis-induced liver injuries was an important first step, but not yet a solution. More research would have to be conducted for evidence of the markers' usefulness in clinical decision making before a practical lab test for patient could be designed.

The two research teams led by Rasmussen and Diamond took different, highly sophisticated approaches to find prognostic markers. The Diamond group performed global protein analyses of liver biopsies taken at 6 months and a year after transplantation. State-of-the art mass spectrometry methods and computational modeling directed them to 250 proteins, out of 4,324 originally uncovered, whose regulation was markedly different in patients with rapidly progressing fibrosis. These patients showed an enrichment of regulatory proteins associated with various immune, liver-protective, and fibrosis-generating processes. The researchers also observed an increase in proinflammatory activity and impairment in antioxidant defenses.

This particular protein-abundance and protein-activity profile occurred in patients who developed severe liver injury. The findings, Diamond and her team noted in their paper, might prove useful in prognosis if they lead to applications for pre
'/>"/>

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Molecular economics: New computer models calculate systems-wide costs of gene expression
2. Scientists discover molecular link between circadian clock disturbances and inflammatory diseases
3. The most celebrated lab manual in molecular biology has been updated and expanded
4. Delving into the molecular mechanism behind deep-sea bacterias pressure tolerance
5. Speed and power of X-ray laser helps unlock molecular mysteries
6. Highlighting molecular clues to the link between childhood maltreatment and later suicide
7. MARC travel award announced for the 2012 GSA Yeast Genetics and Molecular Biology Meeting
8. How bacteria change movement direction in response to oxygen: Molecular interactions unravelled
9. The activity of a bacterial effector protein seen in molecular detail
10. Hitting snooze on the molecular clock: Rabies evolves slower in hibernating bats
11. Molecular spectroscopy tracks living mammalian cells in real time as they differentiate
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecular and protein markers discovered for liver transplant failure from hepatitis C
(Date:11/4/2014)... (Philadelphia, PA) – Temple University School of Medicine ... Explorations winner, an initiative funded by the Bill ... MPH, Professor of Obstetrics, Gynecology and Reproductive Sciences; ... at Temple University School of Medicine will pursue ... titled "Maternal Blood Biomarkers to Assess Fetal Neurodevelopment.", ...
(Date:11/4/2014)... A newly published research study examining only marketing ... of fast food restaurants has found that the ... disproportionately exposed to such marketing tactics. , Authored ... her colleagues, the study is the first to ... interior and exterior of fast food restaurants and ...
(Date:11/4/2014)... – (Nov. 4, 2014) – A majority of Madagascar,s ... that could have serious consequences for the rainforests they ... shows the positive impacts lemurs can have on rainforest ... their disappearance could have on the region,s rich biodiversity. ... have fruits eaten by lemurs. Lemurs in turn ...
Breaking Biology News(10 mins):Temple University School of Medicine receives Grand Challenges Explorations grant 2Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3Gardeners of Madagascar rainforest at risk 2Gardeners of Madagascar rainforest at risk 3
... SEOUL, South Korea, Jan. 8 Pixelplus ... semiconductor company in Korea that designs,develops, and ... electronics,applications, today announced that it unveiled the ... various image recognition,applications., The PM1002 integrates ...
... one cool lily look-alike. This new pinkish-purple ornamental flower, just ... vase, but when left in the garden, it blooms all ... hard freeze in the fall., The new hybrid of the ... Cornell professor, is a non-fragrant perennial that is set apart ...
... (SBS) WHAT: Latest Findings and Research on Advancements ... 6-10, 2008 WHERE: SBS 14th Annual Conference ... More than 2,500 researchers and professionals in the area ... the 14th Annual Conference & Exhibition of the Society for ...
Cached Biology News:Pixelplus Unveils Its PM1002 as A Practical Biometric Solution for Iris, Facial and Fingerprint Recognition 2Pixelplus Unveils Its PM1002 as A Practical Biometric Solution for Iris, Facial and Fingerprint Recognition 3Cornell patents a pink lily look-alike that blooms all summer long 2
(Date:11/22/2014)... CannLabs, Inc. (OTCQB: CANL), ... scientific testing methodologies relating to cannabis, today announced that ... of credit from an existing stockholder of the Company. ... this commitment from one of our existing stockholders,” stated ... capital will help accelerate our planned expansions into the ...
(Date:11/22/2014)... The “Chiral Chromatography Columns Market by type ... Plastic), by Application [GC, LC (HPLC, UHPLC, Flash ... analyses and studies the major market drivers, restraints, ... and Rest of the World. , Browse 90 ... 135 pages and in-depth TOC on “Chiral Chromatography ...
(Date:11/22/2014)... , November 21, 2014 ... wechselt als Chief Commercial Officer zu KLOX    ... der Unternehmensentwicklung und Chief Financial Officer bestellt    ... mit der Vermarktung seines jüngst zugelassenen Behandlungssystems zur Wundheilung ... ("KLOX" bzw. das "Unternehmen") ist sehr erfreut, die folgenden ...
(Date:11/21/2014)... 2014 The science of light and ... with more than 200 primary students in a traveling ... University of Otago Physics Department and funded by an ... members of the university’s OSA/SPIE Student Chapter visited six ... giving children from small, rural schools hands-on lessons in ...
Breaking Biology Technology:CannLabs Secures $750,000 Line Of Credit 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 3Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 4Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 5KLOX Technologies meldet Neubesetzung von Führungspositionen 2KLOX Technologies meldet Neubesetzung von Führungspositionen 3KLOX Technologies meldet Neubesetzung von Führungspositionen 4KLOX Technologies meldet Neubesetzung von Führungspositionen 5Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3
... of excess nuclear fuel may seem like disparate goals ... has obtained the rights to a technology that promises ... Medicine, Inc. , an early-stage developer of radiopharmaceuticals, will ... processing small amounts of unused nuclear fuel left over ...
... a long-time proponent of alternative energy, has joined the biodiesel ... officer. , ,"We are very pleased to have a partner ... H. Tony Hartmann, company CEO. "He is a perfect fit ... in green fuel technology." , ,Daugherty spent the past several ...
... - On June 19 and 20 at the ... private equity, real estate, legal, engineering and due diligence ... many topics on the small and middle markets ($10 ... ,From topics such as "maximizing the value of your ...
Cached Biology Technology:NorthStar finds cancer-fighting use for nuclear fuel 2Some great insights into the current Mergers & Acquisitions Market 2Some great insights into the current Mergers & Acquisitions Market 3Some great insights into the current Mergers & Acquisitions Market 4Some great insights into the current Mergers & Acquisitions Market 5
Mouse monoclonal [RL13] to LAP1 ( Abpromise for all tested applications). SwissProtID: Q96NW7...
Rabbit polyclonal to ECSIT ( Abpromise for all tested applications). entrezGeneID: 51295 SwissProtID: Q96HQ7...
... Antigen peptide transporter ... TAP2) (Peptide transporter PSF2) ... (PSF-2) (Peptide transporter involved ... [Source:Uniprot/SWISSPROT;Acc:Q03519] ...
Goat polyclonal to JIK ( Abpromise for all tested applications). Antigen: Synthetic peptide: HKKDHVFIRDEAGHGD, corresponding to amino acids 396-411 of Human JIK. Entrez Gene ID: 51347 Swi...
Biology Products: