Navigation Links
Molecular '2-way radio' directs nerve cell branching and connectivity
Date:1/7/2013

away from the axon bundle. So Sema-1a acts as an instructional signal and PlexA as its receptor. In the fruit fly study, the scientists discovered that Sema-1a can also act as a receptor for PlexA. "We used to think that this pair of surface proteins acted as a one-way radio, with information flowing in a single direction," says Kolodkin. "What we found is that instructional information flows both ways."

The Johns Hopkins team identified the "two-way" system by knocking out and otherwise manipulating fruit fly genes and then watching what happened to motor neuron branching. In these experiments, the researchers uncovered still other proteins located within the motor axons that Sema-1a interacts with after receiving a PlexA signal. When the gene for a protein called Pebble was deleted, for example, motor axons bunched together and didn't branch. When the gene for RhoGAPp190 was deleted, motor axons branched too soon and failed to recognize their target muscles.

Through a series of biochemical tests, Kolodkin's team found that Pebble and RhoGAPp190 both act on a third protein, Rho1. When Rho1 is activated, it collapses the supporting structures within an axon, making it "limp" and unable to continue toward a target. Sema-1a can bind to Pebble or to RhoGAPp190, and subsequently, these proteins can bind to Rho1. Binding to Pebble activates Rho1, causing axons to branch away from each other. However, binding to RhoGAPp190 shuts down Rho1, causing axons to remain bunched together. Thus, says Kolodkin, balance in the amounts of available Pebble and RhoGAPp190 can determine axon behavior, although what determines this balance is still unknown.

"This signaling is complex and we still don't understand how it's all controlled, but we're one step closer now," says Kolodkin. He notes that "a relative" of the Sema-1a protein in humans has already been implicated in schizophrenia, although details of this protein's role in disease remain unclear. "Our e
'/>"/>

Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scientists pinpoint molecular signals that make some women prone to miscarriage
2. Webcast alert: Molecular Medicine Institute to give new hope to pediatric patients
3. Discovery of molecular pathway of Alzheimers disease reveals new drug targets
4. Ah, that new car smell: NASA technology protects spacecraft from outgassed molecular contaminants
5. New Market Forecasts Available for Critical Global Biotechnology Testing and Screening Markets: Molecular Diagnostics, Hematology, Clinical Chemistry and Nucleic Acid Testing
6. Researchers describe new molecular interactions behind the inhibition of TGF beta-signaling
7. Molecular movies may accelerate anti-cancer drug discovery
8. Molecular and protein markers discovered for liver transplant failure from hepatitis C
9. Molecular economics: New computer models calculate systems-wide costs of gene expression
10. Scientists discover molecular link between circadian clock disturbances and inflammatory diseases
11. The most celebrated lab manual in molecular biology has been updated and expanded
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecular '2-way radio' directs nerve cell branching and connectivity
(Date:9/19/2014)... -- Nxt-ID, Inc. (Nasdaq: NXTD and NXTDW) ("Nxt-ID" ... m-commerce market, updates the "Wocket in Your Pocket" celebrity ad campaign, ... middleweight weight classes, Vinny Pazienza (PAZ). ... of Thrones actor Ciaran Hinds and Sons ... Katey Sagal have been cast in Bleed for This ...
(Date:9/18/2014)... in the primitive brainstem has revealed how we fall ... of Medicine and the University at Buffalo School of ... "sleep node" identified in the mammalian brain whose activity ... deep sleep. , Published online in August in ... of all of the brain,s sleep-promoting activity originates from ...
(Date:9/18/2014)... A team of researchers from McGill University and ... form of polyethylene ,microbeads, Canadian Journal of ... likely originate from cosmetics, household cleansers, or industrial ... abrasives. Owing to their small size and buoyancy, ... Microplastics are a global contaminant in the ...
Breaking Biology News(10 mins):NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 2NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 3No sedative necessary: Scientists discover new 'sleep node' in the brain 2Microplastic pollution discovered in St. Lawrence River sediments 2
... at SUNY Downstate Medical Center,s School of Public Health ... and environmental sources of exposure to mercury. The research, ... factors that may be associated with elevated mercury levels, ... study, published this month in the Journal of ...
... Madison, Wisconsin -- It,s the vicious cycle of funding-- ... The drop leads to declines in faculty and ... to a shortage of qualified graduates. "Obviously if ... have the support staff or the operating budget. ...
... in German . , T-cells are the immune ... the body and put them out of action. Their precursors are ... thymus. Here, they mature and differentiate to perform a variety of ... in Freiburg have now succeeded for the first time in observing ...
Cached Biology News:Study finds Caribbean-American women at higher risk for elevated mercury levels 2Study finds Caribbean-American women at higher risk for elevated mercury levels 3Study finds Caribbean-American women at higher risk for elevated mercury levels 4Live from the thymus: T-cells on the move 2Live from the thymus: T-cells on the move 3
(Date:9/20/2014)... 20, 2014 HealthTronics, Inc. ... interventional radiology products and services, has signed a ... Clinicon Corporation for its high precision ... of minimally invasive, mobile, surgical technology—offering more choices ... the agreement, HealthTronics will make available Clinicon’s FDA-cleared ...
(Date:9/19/2014)... From crop yields to disease risks, the biological characteristics ... traits." Just as for heightthe textbook example of a ... are shaped by multiple genetic and environmental influences, making ... down such genes, geneticists typically mate two individuals that ... a small mouseand then study their descendents, looking for ...
(Date:9/19/2014)... Follow us on LinkedIn ... the world has attracted diverse players including academic ... The early years of nanotechnology development was dominated ... the high risks involved, which deterred private and ... evolving technology have been growing over the years, ...
(Date:9/19/2014)... 2014  Nektar Therapeutics (NASDAQ: NKTR ... the analgesic profiles of a series of the ... molecules. The preclinical research candidates were created using ... The analgesic properties of kappa receptor agonism ... Kappa opioid receptors are expressed in the ...
Breaking Biology Technology:HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 2HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 3Want to link genes to complex traits? Start with more diversity 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 3Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 2Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 5
... Inc., a privately held company developing and commercializing novel ... for new and existing therapeutics, announced today that Edward ... presenting at the Annual UBS Global Life Sciences Conference ... City on Tuesday, September 20, 2011 at 12:30 p.m. ...
... , Chemosaturation Demonstrates Clinically Meaningful Tumor ... Delcath Systems, Inc. (NASDAQ: DCTH ... tumor (mNET) cohort of the Company,s recently completed Phase ... and Interventional Radiological Society of Europe (CIRSE) congress ...
... to be installed at the Rensselaer Polytechnic Institute ... across the nation and boost the university,s international ... high-performance computing, and web science. Funded ... Science Foundation (NSF) and with additional support from ...
Cached Biology Technology:Saladax Biomedical, Inc. to Present at the Annual UBS Global Life Sciences Conference in New York City 2Positive Phase 2 Trial Results from Neuroendocrine Tumor Cohort Presented at CIRSE 2Positive Phase 2 Trial Results from Neuroendocrine Tumor Cohort Presented at CIRSE 3Positive Phase 2 Trial Results from Neuroendocrine Tumor Cohort Presented at CIRSE 4Positive Phase 2 Trial Results from Neuroendocrine Tumor Cohort Presented at CIRSE 5New supercomputer to boost Rensselaer leadership in high-performance computing 2New supercomputer to boost Rensselaer leadership in high-performance computing 3New supercomputer to boost Rensselaer leadership in high-performance computing 4
... cassette is designed to allow ampicillin selection ... gb2 driving the gene for ampicillin resistance ... Em7 promoter. It mediates higher transcription efficiency ... synthetic polyadenylation signal terminates the ampicillin expression. ...
... PRO S-7 stirrers deliver accurate ... channels fluids away from internal ... easy-to-use controls which allow users ... ceramic tops feature a chemical ...
... Agencourt AMPure is a magnetic ... requires no sample transfer, centrifugation ... purifies small and large PCR ... 384-well microplates. Agencourt AMPure can ...
... These 1.5L PYREX trypsinizing ... homogenous tissue samples into cell ... proteins. Heavy beaded neck accepts ... enhance vigorous agitation. • Height ...
Biology Products: