Navigation Links
Molecular '2-way radio' directs nerve cell branching and connectivity
Date:1/7/2013

Working with fruit flies, Johns Hopkins scientists have decoded the activity of protein signals that let certain nerve cells know when and where to branch so that they reach and connect to their correct muscle targets. The proteins' mammalian counterparts are known to have signaling roles in immunity, nervous system and heart development, and tumor progression, suggesting broad implications for human disease research. A report of the research was published online Nov. 21 in the journal Neuron.

To control muscle movements, fruit flies, like other animals, have a set of nerve cells called motor neurons that connect muscle fibers to the nerve cord, a structure similar to the spinal cord, which in turn connects to the brain. During embryonic development, the nerve cells send wire-like projections, or axons, from the nerve cord structure out to their targets. Initially, multiple axons travel together in a convoy, but as they move forward, some axons must exit the "highway" at specific points to reach particular targets.

In their experiments, the researchers learned that axons travelling together have proteins on their surfaces that act like two-way radios, allowing the axons to communicate with each other and coordinate their travel patterns, thus ensuring that every muscle fiber gets connected to a nerve cell. "When axons fail to branch, or when they branch too early and too often, fruits flies, and presumably other animals, can be left without crucial muscle-nerve connections," says Alex Kolodkin, Ph.D., a Howard Hughes investigator and professor of neuroscience at the Institute for Basic Biomedical Sciences at the Johns Hopkins University School of Medicine.

At the center of the communications system, Kolodkin says, is a protein called Sema-1a, already known to reside on the surface of motor neuron axons. If a neighboring axon has a different protein, called PlexA, on its surface, it will be repulsed by Sema-1a and will turn
'/>"/>

Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scientists pinpoint molecular signals that make some women prone to miscarriage
2. Webcast alert: Molecular Medicine Institute to give new hope to pediatric patients
3. Discovery of molecular pathway of Alzheimers disease reveals new drug targets
4. Ah, that new car smell: NASA technology protects spacecraft from outgassed molecular contaminants
5. New Market Forecasts Available for Critical Global Biotechnology Testing and Screening Markets: Molecular Diagnostics, Hematology, Clinical Chemistry and Nucleic Acid Testing
6. Researchers describe new molecular interactions behind the inhibition of TGF beta-signaling
7. Molecular movies may accelerate anti-cancer drug discovery
8. Molecular and protein markers discovered for liver transplant failure from hepatitis C
9. Molecular economics: New computer models calculate systems-wide costs of gene expression
10. Scientists discover molecular link between circadian clock disturbances and inflammatory diseases
11. The most celebrated lab manual in molecular biology has been updated and expanded
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecular '2-way radio' directs nerve cell branching and connectivity
(Date:12/11/2014)... --Research and Markets , ... ) has announced the addition of the ... their offering. One major trend ... multimodal biometric systems. Multimodal biometric systems utilize more ... and identification purposes. This helps to reduce the ...
(Date:12/10/2014)... -- You,ve been here before: you desperately need to sign ... site key or the answer to your secret question. What,s ... Today, Hoyos Labs , a digital infrastructure ... put an end to the frustration that comes with usernames, ... leverages a user,s smartphone to acquire his or her biometrics ...
(Date:12/10/2014)... -- CIE San Diego has launched an innovative trust ... that enhances care coordination among social service and care ... earned a second $1 million grant from the Alliance ... in community and; will be recognized as a "Live ... 4-6p. CIE San Diego today announced the ...
Breaking Biology News(10 mins):Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... more crucial to fundamental global issues, including health, ... Jacobs School of Engineering,s top ranked bioengineering department ... this field. The Siebel Foundation has recognized ... million endowment to fund fellowships for some of ...
... in Canada have established a new university/industry network to ... delivery systems to treat the increasing incidence of eye ... Network) has received $5 million as part of the ... funding announcement made by federal Minister of State (Science ...
... University of Michigan scientists have developed a combination ... medics and fellow soldiers in battle situations to give ... limits morphine,s dangerous side effects. They use ... the drugs into the body. The development of the ...
Cached Biology News:Siebel Foundation awards top UC San Diego bioengineering graduate students 2Siebel Foundation awards top UC San Diego bioengineering graduate students 3Siebel Foundation awards top UC San Diego bioengineering graduate students 4New research network at McMaster aims to build a better eye 2Nanoparticle-based battlefield pain treatment moves a step closer 2
(Date:12/24/2014)... and NEW YORK , Dec. 24, ... a biopharmaceutical company advancing patient care in critical areas, ... 3,500,000 shares of common stock, and warrants to purchase ... at an offering price of $4.00 per share and ... exercise price of $5.00, are exercisable immediately, and expire ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 “Preparative ... Gas, HPLC, Flash), Consumables (Columns, Solvents, Buffers, Valves, ... Food & Agriculture) - Forecasts to 2019” provides ... challenges, opportunities, current market trends, and strategies impacting ... the estimates and forecasts of the revenue and ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 ... series is designed to introduce cutting edge ... users and partners of platform upgrades. This ... benefits; empowering users in their quest to ... tools. , According to SoundConnect’s Marketing Manager, ...
(Date:12/24/2014)... The report provides basic ... definition, classification, application and industry overview. This ... and product cost structure. Production is separated ... also covers upstream raw materials, equipment, downstream ... and proposals. In the end, the export ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2
... , , , BETHESDA, ... ), a biopharmaceutical company developing novel, proprietary antibodies for the ... interim data from a phase 1 dose-escalation clinical study for ... treatment of solid tumors. The interim data(1) were presented at ...
... , , , ... VOLC ), a leader in the development, manufacturing and sales ... artery disease, announced today its participation in the 2009 Transcatheter Cardiovascular ... programming for TCT includes a first look at new study data, ...
... , ST. PAUL, Minn., Sept. 21 Brennen ... its XenMatrix(R) device to Davol Inc., a subsidiary of C.R. Bard, ... related assets of the hernia products business of Brennen Medical, LLC. ... for use in soft tissue repair including hernia and abdominal wall ...
Cached Biology Technology:Micromet Reports Interim Data from Phase 1 Study of BiTE Antibody MT110 for the Treatment of Solid Tumors 2Micromet Reports Interim Data from Phase 1 Study of BiTE Antibody MT110 for the Treatment of Solid Tumors 3Micromet Reports Interim Data from Phase 1 Study of BiTE Antibody MT110 for the Treatment of Solid Tumors 4Volcano Corporation Announces Schedule of Events for the 2009 Transcatheter Cardiovascular Therapeutics (TCT) Conference 2Volcano Corporation Announces Schedule of Events for the 2009 Transcatheter Cardiovascular Therapeutics (TCT) Conference 3Volcano Corporation Announces Schedule of Events for the 2009 Transcatheter Cardiovascular Therapeutics (TCT) Conference 4Volcano Corporation Announces Schedule of Events for the 2009 Transcatheter Cardiovascular Therapeutics (TCT) Conference 5Volcano Corporation Announces Schedule of Events for the 2009 Transcatheter Cardiovascular Therapeutics (TCT) Conference 6Brennen Medical Announces Sale of XenMatrix(R) 2
... assay can detect H2O2 or peroxidase activity ... oxidizes ADHP in a 1:1 stoichiometry to ... 530-571 nm, emission at 590-600 nm). This ... one-step, homogeneous, no wash assay system. ADHP ...
...
Rabbit polyclonal to Staphylococcus Enterotoxin A (HRP) ( Abpromise for all tested applications)....
... net results - with a modular approach ... management! The ChemStation Plus NDS family provides ... acquisition and data management, giving you the ... your labs needs now and that can ...
Biology Products: