Navigation Links
Molding the business end of neurotoxins
Date:2/23/2012

San Diego, Calif. For snakes, spiders, and other venomous creatures, the "business end," or active part, of a toxin is the area on the surface of a protein that is most likely to undergo rapid evolution in response to environmental constraints, say researchers from Ben Gurion University in Israel. Understanding these evolutionary forces can help researchers predict which part of unstudied toxins will do damage, and may also aid in the design of novel synthetic proteins with tailored pharmaceutical properties. The team will present its results at the 56th Annual Meeting of the Biophysical Society, held Feb. 25-29 in San Diego, Calif.

Scientists have long suspected that evolutionary pressures encouraging diversity could play a role in shaping how a toxin works; if such forces were in play, toxins could rapidly evolve within a single species or change quickly from species to species, supporting predators and prey in the "arms race" that keeps them in competition. Still, it was not clear whether the same rules dictate neurotoxin evolution between animals from different phyla (that is, that have very little genetically in common with each other), or whether there were different rules in play for different organisms.

Using the published gene sequences for dozens of different toxins from various species of poisonous scorpions, spiders, and snakes, the Ben Gurion researchers studied toxins that target a variety of ion channels and receptors. They performed their analysis on individual codons, areas of the genetic sequence that code for a single amino acid, which allowed the team to hypothesize about the evolutionary pathways of individual building blocks of the proteins.

In the venoms of all the species they studied, as well as among all the different toxin families, the researchers found a clear correlation between the active parts of the toxins and the parts that evolve most rapidly. In addition, they determined that the non-active surfa
'/>"/>

Contact: Ellen R. Weiss
eweiss@biophysics.org
240-290-5606
American Institute of Physics
Source:Eurekalert

Page: 1 2

Related biology news :

1. SAFRAN to Acquire Motorolas Biometrics Business
2. Entrepreneurs wanted for NJIT workshops about how to launch a business
3. David Rose to present Howe School lecture on new technologies and business models, Jan. 29
4. A sticky business -- how cancer cells become more gloopy as they die
5. Recession Puts Focus on Business Optimisation and Excellence to Strengthen Business Core
6. In troubled economic times, BioSquare 2009 successfully serves as business and innovation starter
7. Business, scientific, higher education groups laud President Obamas commitment to science
8. Platforms in space to help businesses
9. No comfort in comfort foods during tough economic times, says Moore School of Business study
10. Verizon Business to Help Federal Agencies Manage Security Risk, Insider Threats
11. Verizon Business to Provide Global IP for Eurofins Scientific
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/8/2015)... -- Synaptics Inc. (NASDAQ: SYNA ), the leading developer ... executive management team will present at the following investor events: ... Conference Date: May 18, 2015 Time: 10:40am ET ... Cowen and Company Technology, Media & Telecom ... New York Palace Hotel, New York, NY ...
(Date:5/6/2015)... LifeBEAM, a developer of bio-sensing technology, and ... that they will expand their partnership in bio-sensing sports ... helmet and the first joint project between the two ... order to give cyclists more style choices and meet ... Lazer announced their plan to release a new generation ...
(Date:4/27/2015)... 27, 2015  For more than four decades, AUVSI,s ... been the premier worldwide event for the unmanned land, ... must-attend event for any local, national, or trade news ... commercial markets and current applications of unmanned technologies. The ... projected $48 billion industry, and how it will soon ...
Breaking Biology News(10 mins):Synaptics to Present at Upcoming Investor Conferences 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5
... have demonstrated a new way to assess the ... that could also be used to monitor a ... imaging tools. Scientists at the U.S. Department of ... in the February issue of the Society of ...
... on the core cellular mechanisms of sleep, researchers at ... first time a single gene mutation that has a ... sleep. , In its normal state, the Drosophila (fruit ... controls the flow of potassium into cells, a process ...
... drug-resistant, pathogenic bacteria on uncooked poultry products varies by ... in production, according to researchers at the Johns Hopkins ... first to directly compare bacterial contamination of poultry products ... antibiotics and from those who claim they do not. ...
Cached Biology News:PET/MRI scans may help unravel mechanisms of prenatal drug damage 2PET/MRI scans may help unravel mechanisms of prenatal drug damage 3PET/MRI scans may help unravel mechanisms of prenatal drug damage 4Wisconsin researchers identify sleep gene 2Wisconsin researchers identify sleep gene 3Wisconsin researchers identify sleep gene 4Drug-resistant bacteria on poultry products differ by brand 2Drug-resistant bacteria on poultry products differ by brand 3
(Date:5/26/2015)... , Kalifornien und HILDEN, Deutschland, May 26, ... Clinical Insight ®   ... und die Erstellung dazugehöriger Berichte; Vorstellung auf ... QIAGEN N.V. (NASDAQ: QGEN ... die Markteinführung von QIAGEN Clinical Insight ® ...
(Date:5/26/2015)... WALTHAM, Mass. , May 26, 2015  Alere Inc. ... a result of its failure to timely file its Quarterly ... 31, 2015 (the "Form 10-Q"), it has received a notice ... Company is not in compliance with the NYSE,s continued listing ... of the NYSE Listed Company Manual. The ...
(Date:5/26/2015)... , May 26, 2015   PDI ... solutions, today announced that Oakwood Healthcare in ... as the winning entry in Delivering ... professionals who display excellence in building collaborative relationships ... teams in healthcare facilities.  Oakwood ...
(Date:5/26/2015)... 26. mája 2015 Kevin Xu ... rodiny prezidentom Barackovi Obamovi a Billovi Clintonovi za ... stratou Dr. Rongxiang Xu , otca Kevina. ... Dr. Xu bol pionier, inovátor, humanitárny ... odhodlanie v oblasti vedy a príkladné vedenie svojej ...
Breaking Biology Technology:QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 2QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 3QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 4QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 5QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 6PDI Announces Winner in Delivering the Difference Contest 2PDI Announces Winner in Delivering the Difference Contest 3Dr. Rongxiang Xu, O legende 2
... Claire, Wis. - Chippewa Valley Technical College ... week, that CVTC will begin teaching nanotechnology as early ... for sweeping changes and opportunities. , ,Jack Uldrich, nanotechnology ... , described a shift of historic proportions brought on ...
... in the Madison economy since 1906 will be moving its ... , ,According to Atlantic Business Chronicle, 30 top executives and ... surprise to many. , ,We are tremendously disappointed that we ... said Melanie Conklin, spokesperson for Madison Mayor, Dave Cieslewicz. Keeping ...
... EAU CLAIRE, Wis. - Suite Scheduler, a provider of ... alliance with ICE Technologies to resell Suite Scheduler solutions ... based in Iowa, focuses on delivering information technology services ... The company will provide Suite Scheduler products as a ...
Cached Biology Technology:Chippewa Valley Embraces Nanotechnology 2Rayovac to Relocate Headquarters 2
Rabbit polyclonal to M13 Bacteriophage Coat Proteins ( Abpromise for all tested applications)....
E2F-5...
Rabbit polyclonal to Flagellin ( Abpromise for all tested applications). Antigen: Synthetic peptide from the flagellin C terminal domain of Burkholderia pseudomallei....
Novagen's Calf Liver tRNA is qualified for use in reticulocyte lysates for in vitro translation, and is the same supplement used in the Red Nova Lysate ....
Biology Products: