Navigation Links
Molding the business end of neurotoxins
Date:2/23/2012

San Diego, Calif. For snakes, spiders, and other venomous creatures, the "business end," or active part, of a toxin is the area on the surface of a protein that is most likely to undergo rapid evolution in response to environmental constraints, say researchers from Ben Gurion University in Israel. Understanding these evolutionary forces can help researchers predict which part of unstudied toxins will do damage, and may also aid in the design of novel synthetic proteins with tailored pharmaceutical properties. The team will present its results at the 56th Annual Meeting of the Biophysical Society, held Feb. 25-29 in San Diego, Calif.

Scientists have long suspected that evolutionary pressures encouraging diversity could play a role in shaping how a toxin works; if such forces were in play, toxins could rapidly evolve within a single species or change quickly from species to species, supporting predators and prey in the "arms race" that keeps them in competition. Still, it was not clear whether the same rules dictate neurotoxin evolution between animals from different phyla (that is, that have very little genetically in common with each other), or whether there were different rules in play for different organisms.

Using the published gene sequences for dozens of different toxins from various species of poisonous scorpions, spiders, and snakes, the Ben Gurion researchers studied toxins that target a variety of ion channels and receptors. They performed their analysis on individual codons, areas of the genetic sequence that code for a single amino acid, which allowed the team to hypothesize about the evolutionary pathways of individual building blocks of the proteins.

In the venoms of all the species they studied, as well as among all the different toxin families, the researchers found a clear correlation between the active parts of the toxins and the parts that evolve most rapidly. In addition, they determined that the non-active surfa
'/>"/>

Contact: Ellen R. Weiss
eweiss@biophysics.org
240-290-5606
American Institute of Physics
Source:Eurekalert

Page: 1 2

Related biology news :

1. SAFRAN to Acquire Motorolas Biometrics Business
2. Entrepreneurs wanted for NJIT workshops about how to launch a business
3. David Rose to present Howe School lecture on new technologies and business models, Jan. 29
4. A sticky business -- how cancer cells become more gloopy as they die
5. Recession Puts Focus on Business Optimisation and Excellence to Strengthen Business Core
6. In troubled economic times, BioSquare 2009 successfully serves as business and innovation starter
7. Business, scientific, higher education groups laud President Obamas commitment to science
8. Platforms in space to help businesses
9. No comfort in comfort foods during tough economic times, says Moore School of Business study
10. Verizon Business to Help Federal Agencies Manage Security Risk, Insider Threats
11. Verizon Business to Provide Global IP for Eurofins Scientific
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... 18, 2014 Research and Markets ... the "iPhone 5S Fingerprint Sensor - Apple/AuthenTec ... to their offering. ... AuthenTec in July 2012, Apple introduced the fingerprint ... currently the only device of Apple incorporating such ...
(Date:12/17/2014)... , Dec. 15, 2014 The Defense ... it easier to detect and prevent counterfeit microcircuits ... Today the agency started performing an in-house microcircuit ... validate the authenticity of purchased microcircuits while increasing ... quality control measures will be conducted at DLA,s ...
(Date:12/15/2014)... Research and Markets ( http://www.researchandmarkets.com/research/87pph8/global_facial ... "Global Facial Recognition Market 2015-2019" report to ... Facial recognition is a technology ... system measures the overall facial feature of a ... the distance between eyes. Facial recognition is used ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... first got its grip in California,s forests outside a nursery ... before spreading out to eventually kill millions of oaks and ... led by researchers at the University of California, Berkeley. It ... unfolded in this state. "In this paper, we actually ...
... researchers have discovered an important clue to how iron ... the body. The finding could lead to developing new ... nutritional disorder., With C. elegans, a common microscopic worm ... animal and avian sciences, and his team identified previously ...
... have developed a technique for imaging cells under an electron ... chromatin, the tightly wound bundle of genetic material and proteins ... Nature Methods. Scientists have known for more than a ... into the nucleus of a cell. Human cells contain 2 ...
Cached Biology News:Sudden Oak Death pathogen is evolving, says new study that reconstructs the epidemic 2Sudden Oak Death pathogen is evolving, says new study that reconstructs the epidemic 3Sudden Oak Death pathogen is evolving, says new study that reconstructs the epidemic 4Bloodless worm sheds light on human blood, iron deficiency 2Bloodless worm sheds light on human blood, iron deficiency 3New technique yields more detailed picture of chromatin structure 2New technique yields more detailed picture of chromatin structure 3
(Date:12/24/2014)... NEW YORK , Dec. 23, 2014 ... pilot study of mazindol in children with attention deficit/hyperactivity ... in December 2014 . The paper, ... with attention deficit/hyperactivity disorder" ( Konofal et al, ... 1;8:2321-2332. eCollection 2014 ) shows that mazindol might ...
(Date:12/22/2014)... Dec. 22, 2014 GenomeDx Biosciences today announced ... Cancer Classifier, a genomic test for prostate cancer, was ... men managed by radical prostatectomy without adjuvant therapy. Although ... relatively uncommon, using tumor genomics to identify these men ... is an important advance. The study has been ...
(Date:12/19/2014)... Hershey, PA (PRWEB) December 19, 2014 ... a leading developer and manufacturer of needle-free injection ... an agreement with Immunomic Therapeutics, Inc. (“ITI”) for ... injection device with its LAMP™ vaccine platform. ... for an exclusive Worldwide license to the Biojector®-2000 ...
(Date:12/19/2014)... -- Bina Technologies, Inc. (Bina, Redwood City, ... been acquired by Roche (SIX: RO, ROG; OTCQX: RHHBY).  ... that provides a big data platform for centralized management ... the academic and translational research markets.  Bina will be ... to focus on development of their innovative genomic analysis ...
Breaking Biology Technology:Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... Magnetics, the first start-up company spun off by The ... advance development of an innovative drug delivery system using ... Vascular Magnetics, based in West Philadelphia, announced that ... investor in this Series A financing agreement. ...
... March 1, 2012 Reportlinker.com announces that ... in its catalogue: Global ... The global outlook series on Biotechnology ... briefs, and concise summaries of research findings. ...
... that the company is scheduled to present at the Cowen ... on Wednesday, March 7, 2012, at the Boston Marriott Copley ... officer, will provide an overview of the company and an ... is an exciting time at Receptos as we move forward ...
Cached Biology Technology:Biotech Firm Spun Off from Children's Hospital Raises $7 Million to Advance Magnetic-Based Vascular Treatment 2Biotech Firm Spun Off from Children's Hospital Raises $7 Million to Advance Magnetic-Based Vascular Treatment 3Global Biotechnology Industry 2Global Biotechnology Industry 3Global Biotechnology Industry 4Global Biotechnology Industry 5Global Biotechnology Industry 6Receptos to Present at the Cowen and Company 32nd Annual Health Care Conference 2
... low background ,This solution greatly enhances antigen-antibody ... than obtained with conventional methods. ,Two kinds ... secondary antibodies, which can suppress the background ... Wide versatility ,It is applicable to various ...
Monocarboxylate (lactate) transporter 2...
Mouse anti human pro-Relaxin-2...
Anti-Chicken IgY, (IgG) F(ab')2 Fragment Specific....
Biology Products: