Navigation Links
Modulator of fetal hemoglobin switch may target sickle cell disease
Date:7/12/2010

health problems resulting from their blood cells' impaired oxygen delivery.

Hydroxyurea, a drug used to treat sickle cell disease, increases the percentages of fetal hemoglobin in some patients but it's an indirect action that comes with a lot of side effects, she said. The new findings led her to speculate that if hydroxyurea activates the fetal gamma gene through increasing the supply of NF-Y and/or GATA-2 in red blood cells, then designing drugs to directly increase the amount of these transcription factors would yield the same benefit with fewer side effects.

She notes that the thousands of copies of ERV-9 found in human chromosomes likely help modulate the activity of other genes.


'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Emerald BioStructures announces discovery of small molecule modulators of PDE4
2. Little is understood about alcohols effect on fetal development, Georgetown researchers say
3. Fetal surgery continues to advance
4. Study shows male erectile dysfunction drug enhances fetal growth in female sheep
5. Mussel-inspired glue for fetal membrane repair
6. March of Dimes honors Dr. Gail Harrison for outstanding work in maternal-fetal nutrition
7. Scientists discover key factor in regulating placenta and fetal growth
8. Mothers immune system may block fetal treatments for blood diseases
9. Specific genetic cause of fetal alcohol-related developmental disorders found
10. Effects of maternal exercise on fetal breathing movements
11. Effects of maternal exercise on fetal breathing movements
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Modulator of fetal hemoglobin switch may target sickle cell disease
(Date:9/18/2014)... 18, 2014 New research into the Crimean-Congo hemorrhagic ... severe hemorrhagic disease in humans similar to that caused ... CCHFV infection. This discovery has the potential to lead ... , The research, reported in a paper ... and conducted by scientists at the Texas Biomedical Research ...
(Date:9/18/2014)... International Space Station ever starts a "frequent flyers" program, ... Recently the orbiting laboratory has hosted increasing numbers of ... from the space station in April, and another is ... experiment is planned to launch in December. , Fruit ... the world-- and in space. Model organisms can reveal ...
(Date:9/18/2014)... language is unique to humans. "The genetic changes that ... evolution to make this possible are largely unknown, but ... says Wolfgang Enard, Professor of Anthropology and Human Biology ... biological basis of language Enard has now taken an ... undertaken in collaboration with scientists at several universities, including ...
Breaking Biology News(10 mins):Research milestone in CCHF virus could help identify new treatments 2Buzzing with activity: Fruit flies orbit Earth for science 2Buzzing with activity: Fruit flies orbit Earth for science 3Buzzing with activity: Fruit flies orbit Earth for science 4Language evolution: Quicker on the uptake 2Language evolution: Quicker on the uptake 3
... A team led by researchers at the University ... the "superbug" methicillin-resistant Staphylococcus aureus (MRSA) is ... is well known for causing difficult-to-treat and potentially fatal ... 1990s it has also been infecting otherwise healthy people ...
... study shows for the first time that episodes of ... the 2001-02 drought, greatly accelerated development of the mountain ... to chart the evolution of the current pine beetle ... beetle outbreak in the two primary host species, the ...
... a daily multivitamin, but little is known about a multivitamin,s ... Brigham and Women,s Hospital (BWH) finds that daily multivitamin use ... A similar BWH study, announced last month, found daily ... 8 percent. The cardiovascular disease findings will be presented ...
Cached Biology News:Superbug MRSA identified in US wastewater treatment plants 22001-2002 drought helped propel mountain pine beetle epidemic, says CU study 22001-2002 drought helped propel mountain pine beetle epidemic, says CU study 32001-2002 drought helped propel mountain pine beetle epidemic, says CU study 4Daily multivitamin use does not reduce cardiovascular disease risk in men 2
(Date:9/19/2014)... , Sept. 19, 2014 Pfenex Inc. ... the development of high-value and difficult to manufacture proteins ... presenting at the 21 st Annual NewsMakers in ... . Bertrand Liang , chief executive officer ... development programs and business strategy on Friday, September 26, ...
(Date:9/19/2014)... September 19, 2014 Barnhardt Manufacturing ... Label for its Organic Cotton . The USDA ... of renewable biobased ingredients meets or exceeds levels set ... composed in whole or in significant part of agricultural, ... allow our Organic cotton to be immediately identified as ...
(Date:9/19/2014)... , September 19, 2014 ... Markets ( http://www.researchandmarkets.com/research/b2jxhs/micro_market ) has announced the addition of ... Columns"  report to their offering.       ... is one of the fastest-growing segments in the ... billion in 2013, and expected to reach $2.0 ...
(Date:9/19/2014)... September 19, 2014 The new , ... , available today on PharmaBoardroom.com for ... crisis that rocked the Spanish economy in 2009, and the ... community has remained pragmatic in times of trouble. ... the fifth biggest European market, and the general conditions to ...
Breaking Biology Technology:Pfenex to Present at Upcoming Industry Conference on September 26 2Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2Micro Market Monitor : Global Pre-packed Chromatography Columns 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3
... Wis. - Commercial air service doesn't always ... viewed as more fundamental to enterprise than ever ... potential customers to dismiss the expenses of putting ... of Internet video and mixed-media communication tools. , ...
... a visit to the University of Wisconsin-Madison campus, former ... his name is under attack from critics who don't understand the ... at the annual Kastenmeier Lecture at the UW-Madison Law School ... Bayh-Dole Act , which gave universities the right to patent ...
... back, we took a look at the results of the National ... time, we saw that the Midwest had two states in the top ... top 20 states. I promised to circle back with you to review ... Midwest fared in this ranking. , ,The NIH falls under the ...
Cached Biology Technology:IP video goes where air travel cannot 2IP video goes where air travel cannot 3Landmark patent law under attack, Bayh says 2Landmark patent law under attack, Bayh says 3Midwest colleges strong contenders for NIH funds 2Midwest colleges strong contenders for NIH funds 3Midwest colleges strong contenders for NIH funds 4Midwest colleges strong contenders for NIH funds 5
... SNPstream System Delivers 4,600 to Over 3 ... Genotyping System is capable of performing 4,600 ... Part of the GenomeLab family of products*, ... up to 48 SNPs in each well ...
Mouse monoclonal antibody to ACP2 - acid phosphatase 2, lysosomal...
Mouse monoclonal antibody to DCAMKL2 - doublecortin and CaM kinase-like 2...
... Tube Disperser System from IKA Works is the ... cleaner, safer, and more efficient way to disperse ... 2 to 15 ml inside sealed tubes. Depending ... of 4 different tube types. Each tube is ...
Biology Products: