Navigation Links
Modulator of fetal hemoglobin switch may target sickle cell disease
Date:7/12/2010

patients with sickle cell disease," Tuan said. "I think we have put our fingers on a key switching mechanism."

Without ERV-9, the adult hemoglobin gene is not as competitive for the transcription factors NF-Y and GATA-2 that it needs to be highly expressed. Still, it's a long-distance relationship: ERV-9 and the adult hemoglobin gene sit far apart on a stretch of DNA. One of Tuan's many follow-up studies is determining whether during development, ERV-9 favors the fetal hemoglobin gene, a much closer DNA neighbor.

"We want to study fetal red blood cells and see what ERV-9 is doing there," Tuan said. She also wants to better understand ERV-9's apparent ability to suppress globin genes by studying how, during development, its own DNA is chemically altered in a process called epigenetics.

DNA has four chemical bases A, G, C and T and ERV-9's DNA contains a lot of the C, or cytosine, which is easily chemically altered. The net effect of chemical alteration part of normal development is gene suppression.

If her hypothesis is correct and the fetal and adult genes are competing for NF-Y and GATA-2, what happens if there is a bigger supply of these transcription factors? "If you can increase NF-Y and GATA-2 so there is plenty around, maybe both the beta and gamma genes will be activated without one suppressing the other," Tuan said.

She has a $1.9 million grant from the National Heart, Lung and Blood Institute to further explore whether this natural mechanism she has identified might benefit sickle cell patients. There's plenty of proof that increasing fetal hemoglobin percentages helps patients. A small percentage of people with sickle cell disease, who for some unknown reason continue to express higher levels of fetal hemoglobin about 25 percent instead of the 1-2 percent expressed by most are asymptomatic, Tuan said. Typical sickle cell patients, on the other hand, suffer frequent fatigue, pain and a myriad of other
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Emerald BioStructures announces discovery of small molecule modulators of PDE4
2. Little is understood about alcohols effect on fetal development, Georgetown researchers say
3. Fetal surgery continues to advance
4. Study shows male erectile dysfunction drug enhances fetal growth in female sheep
5. Mussel-inspired glue for fetal membrane repair
6. March of Dimes honors Dr. Gail Harrison for outstanding work in maternal-fetal nutrition
7. Scientists discover key factor in regulating placenta and fetal growth
8. Mothers immune system may block fetal treatments for blood diseases
9. Specific genetic cause of fetal alcohol-related developmental disorders found
10. Effects of maternal exercise on fetal breathing movements
11. Effects of maternal exercise on fetal breathing movements
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Modulator of fetal hemoglobin switch may target sickle cell disease
(Date:9/21/2014)... researchers has developed a protein therapy that disrupts the ... original tumor sites, travel through the blood stream and ... This process, known as metastasis, can cause cancer to ... patients who succumb to cancer fall prey to metastatic ... professor of bioengineering who describes a new therapeutic approach ...
(Date:9/19/2014)... Oklahoma biology professor will study multifunctional and specialized ... with a National Science Foundation grant in the ... Ari Berkowitz, professor in the Department of Biology, ... on the differences between the multifunctional and specialized ... they use and what connections they make. ...
(Date:9/19/2014)... regulate their symbiotic relationship with soil bacteria by ... plant structure from leaves into the roots to ... roots. This collaborative study was conducted by researchers ... Graduate University for Advanced Studies (SOKENDAI), and the ... , Legumes, an important plant family which ...
Breaking Biology News(10 mins):Stanford researchers create 'evolved' protein that may stop cancer from spreading 2Stanford researchers create 'evolved' protein that may stop cancer from spreading 3Stanford researchers create 'evolved' protein that may stop cancer from spreading 4For legume plants, a new route from shoot to root 2
... drug normally reserved for treating patients during a heart attack, ... patients who could be revived from cardiac arrest. This sudden ... a year nationwide ?and at least 93 percent of them ... for this abrupt and catastrophic loss of heart function," said ...
... the International Rice Research Institute (IRRI) is working with ... Asian Nations (ASEAN) to develop a series of environmental ... implemented, the indicators will allow each country to monitor ... with that of its neighbors, and either correct any ...
... allergic reactions in humans is a big reason for ... to ask questions about the allergy-causing possibilities, there has ... all of that could change as a Michigan State ... test whether genetically engineered foods could cause human allergic ...
Cached Biology News:Clot-busting drug helps revive cardiac arrest patients 2A cleaner, greener rice industry 2Tests may help answer questions about GMOs and allergies 2
(Date:9/22/2014)...  WIRB-Copernicus Group (WCG), the world,s largest provider ... research, announced today that its Western Institutional Review ... the Association for the Accreditation of Human Research ... for clinical research participants. WCG Chairman ... commented, "It is of utmost importance to WCG ...
(Date:9/22/2014)... 22, 2014 METTLER TOLEDO is ... pallet measuring device CNS110 ScanTape™ . Replacing ... entry, offering greater ease and accuracy for transport ... can significantly enhance productivity—an important benefit for load ... volume equals profits. , Usable at any ...
(Date:9/22/2014)...  Spherix Incorporated (SPEX) -- an intellectual property development company ... announced that the United States Patent & Trademark Office (USPTO) ... of September that is part of a standard essential family ... , Application number: US 13/728,867 , Publication ... 2012 The listed inventors of the new ...
(Date:9/21/2014)... the first time, scientists have discovered how to produce ... and stiffness greater than that of today,s strongest nanotubes ... research team led by John V. Badding, a professor ... in the 21 September 2014 issue of the journal ... of view, our discovery is intriguing because the threads ...
Breaking Biology Technology:Western IRB (WIRB) Awarded AAHRPP Reaccreditation 2ScanTape™ Handheld Dimensioner Increases Processing Volume 2Spherix Notified by United States Patent & Trademark Office of New Standard Essential Patent Issued to Spherix 2Spherix Notified by United States Patent & Trademark Office of New Standard Essential Patent Issued to Spherix 3Smallest possible diamonds form ultra-thin nanothreads 2Smallest possible diamonds form ultra-thin nanothreads 3Smallest possible diamonds form ultra-thin nanothreads 4
... (Nasdaq: KERX ) announced today that it has ... the Company is not in,compliance with the $1.00 minimum ... Market pursuant to Marketplace Rule 4450,(a)(5). This notification, which ... a standard communication when the bid price of a ...
... REYKJAVIK, Iceland, April 25 deCODE genetics,(Nasdaq: ... the Genetic,Information Non-discrimination Act (GINA), a bill that, ... through Congress and is expected to be signed,promptly ... counterpart to,existing legislation in many states prohibiting discrimination ...
... The Fraunhofer Center for,Manufacturing Innovation, Boston University ... and Nanobiotechnology hosted the prestigious Society,of Manufacturing ... their world class,facilities located on the campus ... included demonstrations of their new technological,advancements in ...
Cached Biology Technology:Keryx Biopharmaceuticals Receives Nasdaq Notification 2Keryx Biopharmaceuticals Receives Nasdaq Notification 3deCODE Lauds Federal Legislation to Ban Discrimination on the Basis of Genetic Information 2deCODE Lauds Federal Legislation to Ban Discrimination on the Basis of Genetic Information 3deCODE Lauds Federal Legislation to Ban Discrimination on the Basis of Genetic Information 4Fraunhofer and Boston University Hosted Prestigious SME Tour 2
... dispensers save space and organize ... and other garb. They are ... for small parts used in ... acrylic. Open-slot design for easy ...
... Microarrays designed for genome-wide microRNA ... flexible and powerful Paraflo microfluidic on-chip ... as part of our comprehensive microRNA ... Content The Soil Nematode microRNA ...
... is critical to the maintenance of ... proteins as important and diverse as ... shock and stress response, antigen presentation, ... ion channels, cell cycle regulation, transcription, ...
... Proteolytic degradation is critical to ... short-lived and regulatory proteins as important ... cellular metabolism, heat shock and stress ... surface receptors and ion channels, cell ...
Biology Products: