Navigation Links
Modified gene targets cancer cells a thousand times more often than healthy cells
Date:12/17/2008

d in DNA repair, which explains why it's more often expressed in cancer cells. Cancer cells reproduce at accelerated rates, often "not stopping to fix their DNA when they should," says Gorbunova. In these cancer cells, Rad51 is working overtime to repair all the damage, so it's not surprising that it is expressed more often.

Gorbunova believes that when she stripped out part of the Rad51-coding gene, she also stripped out some regulatory elements, which control the production of the protein. Without these elements, healthy cells ignore the gene and do not make the protein. However, these changes have opposite the effect on cancer cells, causing elevated, uncontrolled protein production.

Gobunova and her team have already fused a variant of diphtheria toxin into the Rad51 gene as a "toxic bomb" and tested it on a variety of cancer cell types, including breast cancer, fibrosarcoma, and cervical cancer cells. The results look very promising, she says.

"The early results show the new Rad51 killed all of the cancer cells with minimal if any effect on normal cells," says Gorbunova. "We're very excited. The results are much more striking than anything we would have guessed."

Gorbunova is now working with Stephen Dewhurst, professor of miocrobiology and immunology at the University of Rochester School of Medicine and Dentistry, to design a way to incorporate the new gene with its toxic cargo into a benign virus. If successful, the team will attempt to treat cancer in mice by injecting their tumors with a solution of the virus, and allow the virus to implant the gene into all cells. The key question is whether a dose high enough to kill the cancer cells also will be high enough to kill healthy cells in a living animal, despite the thousand-fold difference in the two cell types' levels of expression.

If the tests are successful, Gorbunova hopes the process might be someday given as a simple shot-in-the-arm, which might travel throughout the bloodstream an
'/>"/>

Contact: Jonathan Sherwood
jonathan.sherwood@rochester.edu
585-273-4726
University of Rochester
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Novel bioreactor enhances interleukin-12 production in genetically modified tobacco plants
2. Technique used in human ankle injuries modified to treat dogs knees
3. Genetically modified carrots provide more calcium
4. Penn Veterinary Medicine report new strategy to create genetically-modified animals
5. UQ research targets West Nile virus and dengue fever
6. New genes present drug targets for managing cholesterol and glucose levels
7. First comprehensive genomic study of common cold reveals new treatment targets
8. US Air Force grant targets medical evacuation procedures
9. Viral magic bullet targets cancer cells with help of new compound
10. Media invitation: 20th EORTC-NCI-ACR Symposium on Molecular Targets and Cancer Therapeutics
11. N.Y. research team discovers how antidepressants and cocaine interact with brain cell targets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... based upon a proxy for impact have been identified ... approach to scientific research. , The researchers from the ... top 100 pathogens affecting humans and the top 100 ... will help governments across the continent plan for risks ... a result of climate change, and for biosecurity. , ...
(Date:8/27/2014)... German . , ... disease affecting the peripheral nervous system. Researchers from the ... Experimental Medicine and University Medical Centre Gttingen have discovered ... rats with the disease. These cells enwrap the nerve ... facilitates the rapid transfer of electrical impulses. If Schwann ...
(Date:8/27/2014)... (June, 2014) Outstanding basic research, a growing ... dedication to patient care have earned the Herbert ... Medical Center (CUMC) and NewYork-Presbyterian Hospital an $18 ... National Cancer Institute (NCI). The grant renews the ... Comprehensive Cancer Centers in New York City and ...
Breaking Biology News(10 mins):Big data approach identifies Europe's most dangerous human and domestic animal pathogens 2Potential therapy for incurable Charcot-Marie-Tooth disease 2Herbert Irving Comprehensive Cancer Center awarded $18 million grant 2Herbert Irving Comprehensive Cancer Center awarded $18 million grant 3Herbert Irving Comprehensive Cancer Center awarded $18 million grant 4
... Children,s Research Hospital have gained new insights into regulation ... As the cell,s molecular overachievers, calpains function ... in tissues, the death of damaged cells, insulin secretion, ... this broad set of responsibilities is that defective or ...
... latest American Chemical Society (ACS) News Service Weekly PressPac with ... Engineering News .,Please credit the individual journal or the American ... CONTENT IS FOR IMMEDIATE RELEASE EXCEPT ARTICLE #5, which is ... ARTICLE #1 FOR IMMEDIATE RELEASE Microcapsules ...
... on the hunt for a better way to clean up ... them watch molecules break down on the surface of a ... "We can see the vibrations of the bonds between the ... the way these vibrations change frequency and intensity with time, ...
Cached Biology News:New insight into the controls on a go-to enzyme 2New insight into the controls on a go-to enzyme 3American Chemical Society's Weekly PressPac -- Nov. 19, 2008 2American Chemical Society's Weekly PressPac -- Nov. 19, 2008 3American Chemical Society's Weekly PressPac -- Nov. 19, 2008 4American Chemical Society's Weekly PressPac -- Nov. 19, 2008 5American Chemical Society's Weekly PressPac -- Nov. 19, 2008 6American Chemical Society's Weekly PressPac -- Nov. 19, 2008 7American Chemical Society's Weekly PressPac -- Nov. 19, 2008 8Researchers shed new light on catalyzed reactions 2Researchers shed new light on catalyzed reactions 3
(Date:8/27/2014)... Varian Medical Systems today broke ground ... Lake City manufacturing facility and allow for the consolidation ... create 1,000 new full time jobs in the state ... home to hardworking people with immense engineering and technical ... success in the manufacturing of our state-of-the-art X-ray technology,” ...
(Date:8/27/2014)... YORK , Aug. 27, 2014 /PRNewswire/ ... research report is available in its catalogue: ... 2014-2018 http://www.reportlinker.com/p02316661/Global-Biodegradable-Packaging-Materials-Market-2014-2018.html ... materials are materials that are readily decomposed ... differs from conventional non-degradable packaging in terms ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportlinker.com announces ... in its catalogue: Global Chelating Agents ... About Chelating Agent A chelating agent ... bonds with metal ions, thereby forming a metal-ion ... metal-ions have on chemical processes, formulations, and the ...
(Date:8/27/2014)... “We are honored to be named ... Thangaraj, CEO of Radiant Sage. “We are offering truly ... imaging corelab market to a different level. We ... to efficiently and effectively manage the massive amounts of ... analyzed and read by trained physicians. Being recognized by ...
Breaking Biology Technology:Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 3Global Biodegradable Packaging Materials Market 2014-2018 2Global Biodegradable Packaging Materials Market 2014-2018 3Global Biodegradable Packaging Materials Market 2014-2018 4Global Biodegradable Packaging Materials Market 2014-2018 5Global Biodegradable Packaging Materials Market 2014-2018 6Global Biodegradable Packaging Materials Market 2014-2018 7Global Chelating Agents Market 2014-2018 2Global Chelating Agents Market 2014-2018 3Global Chelating Agents Market 2014-2018 4Radiant Sage Named to CIOReview List of 100 Most Promising Technology Companies 2
... great thing about the tech arena: even when the economy ... them turn into start-up ventures (whether self-funded, friends-and-family backed or ... they tend to create jobs. They create lots of jobs. ... companies. , ,The trend shows no sign of slowing. , ...
... into two major groups: open minds in closed societies and ... of products must address the issues of sexual connotation with ... UK went soft and packed up their most cherished and ... all over the world are happy as they seriously objected ...
... nanotechnology exhibit to open Thursday , Madison, Wis. ... an exhibit on advances in nanotechnology, run by the university ... 4:30 p.m. on December 16 during a campus open house, ... in science fiction as the manufacture of tiny robots, has ...
Cached Biology Technology:How to duck the 3 most common entrepreneurial hiring traps 2How to duck the 3 most common entrepreneurial hiring traps 3How to duck the 3 most common entrepreneurial hiring traps 4We are American No sex, please 2We are American No sex, please 3We are American No sex, please 4Tech Digest: Nanotechnology, GE Healthcare, NovaMed, PhysioGenix 2
Mouse monoclonal [ICRF 44] to Integrin alpha M...
CKB Antibody (N-term) Antigen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected within aa 1~100 of human CKB. Molecular Weight: 42644 Da...
384 Cluster Tube Racks...
Leptin Receptor Polyclonal Ab 100 ug purified rabbit anti-mouse Leptin Receptor. Tested in Western blotting....
Biology Products: