Navigation Links
Modifications of a nanoparticle can change chemical interactions with cell membranes
Date:1/23/2013

Researchers at Syracuse University's Department of Biomedical and Chemical Engineering at L.C. Smith College of Engineering and Computer Science are studying the toxicity of commonly used nanoparticles, particles up to one million times smaller than a millimeter that could potentially penetrate and damage cell membranes.

In a recent article published along with cover art in the leading journal Langmuir entitled "Effects of nanoparticle charge and shape anisotropy on translocation through cell membranes," researchers Shikha Nangia, assistant professor of biomedical and chemical engineering (BMCE), and Radhakrishna Sureshkumar, Department Chair of BMCE and professor of physics, showed how simple shape and charge modifications of a nanoparticle can cause tremendous changes in the chemical interactions between the nanoparticle and a cell membrane.

Nanomaterials, which are currently being used as drug carriers, also pose a legitimate concern, since no universal standards exist to educate and fully protect those who handle these materials. Nanoparticles are comparable to chemicals in their potential threat because they could easily penetrate the skin or be inhaled.

"Nanotechnology has immense potential that is starting to be being realized; a comprehensive understanding of toxicity of nanoparticles will help develop better safe handling procedures in nanomanufacturing and nano-biotechnology" says Sureshkumar and Nangia, In addition, the toxicity levels of various nanoparticles can be used to our advantage in targeting cancer cells and absorbing radiation during cancer therapy. Nanotoxicity is becoming a major concern as the use of nanoparticles in imaging, therapeutics, diagnostics, catalysis, sensing and energy harvesting continues to grow dramatically.

This research project has taken place over the past year utilizing a state of the art 448 core parallel computer nicknamed "Prophet" housed in Syracuse University's Green Data Center. The research was funded by the National Science Foundation.


'/>"/>

Contact: Ariel DuChene
adduchen@syr.edu
315-443-2546
Syracuse University
Source:Eurekalert

Related biology news :

1. Scientists uncover mechanism by which plants inherit epigenetic modifications
2. Are silver nanoparticles harmful?
3. Hybrid copper-gold nanoparticles convert CO2
4. NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
5. From pomegranate peel to nanoparticles
6. Palladium-gold nanoparticles clean TCE a billion times faster than iron filings
7. Paints and coatings containing bactericidal agent nanoparticles combat marine fouling
8. Silver nanoparticle synthesis using strawberry tree leaf
9. Oh, my stars and hexagons! DNA code shapes gold nanoparticles
10. Nanoparticles added to platelets double internal injury survival rate
11. Nanoparticles reboot blood flow in brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... GOTHENBURG, Sweden , April 28, 2016 ... 1,491.2 M (139.9), up 966% compared with the first quarter of ... Operating profit totaled SEK 589.1 M (loss: 18.8) and the operating ... SEK 7.12 (loss: 0.32) Cash flow from operations was ... , The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
(Date:4/15/2016)... 2016 Research and Markets has ... Market 2016-2020,"  report to their offering.  , ... ,The global gait biometrics market is expected to ... period 2016-2020. Gait analysis generates multiple ... used to compute factors that are not or ...
(Date:3/29/2016)... Florida , March 29, 2016 ... the "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased ... in ink used in a variety of writing instruments, ... Buyers of originally created collectibles from athletes on LegacyXChange ... forensic analysis of the DNA. Bill ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Prairie, WI (PRWEB) , ... June 23, 2016 ... ... consultancy focused on quality, regulatory and technical consulting, provides a free webinar ... is presented on July 13, 2016 at 12pm CT at no charge. , ...
(Date:6/23/2016)... , June 23, 2016 ... market research report to its pharmaceuticals section with ... product details and much more. Complete ... across 151 pages, profiling 15 companies and supported ... at http://www.reportsnreports.com/reports/601420-global-cell-culture-media-industry-2016-market-research-report.html . The ...
(Date:6/22/2016)... YORK , June 22, 2016  According ... growing next generation sequencing (NGS) market include significant ... of smaller sequencers.  More accessible and affordable sequencers, ... to growing demand for consumables including sample prep ... The Market for Sample Preparation for Next Generation ...
(Date:6/22/2016)... SAN DIEGO , June 22, 2016   ... the first pluripotent stem cell-derived islet replacement therapy for ... two presentations at ISSCR 2016 Annual Meeting.  ISSCR 2016, ... 22nd to 25th at Moscone West in San Francisco.  ... Details of the presentations are as follows:Event: , Focus ...
Breaking Biology Technology: