Navigation Links
Modest familial risks for multiple sclerosis
Date:1/22/2014

Even though multiple sclerosis is largely caused by genetic factors, the risk of patients' relatives developing the disease is lower than previously assumed. This is the conclusion of a new population registry-based study, published in the scientific journal Brain.

In the present study from Karolinska Institutet, researchers have assessed the familial risks for multiple sclerosis (MS) by using population registers and health care registries. This way, the researchers were able to include in their study almost everyone diagnosed with the disease in Sweden. Slightly over 28,000 individuals diagnosed with MS from 1968 onwards were identified. By using the Swedish Multi-generation registry, both biological and adopted relatives were identified and the researchers could assess the risks for the different groups.

This is the first study for MS in which the familial risks have been analysed using matched controls. By including randomly selected controls and their relatives, the researchers could also assess the risk for relatives of MS patients developing the disease compared to the risk for the population in general.

The estimated risks in this study turned out lower than the previously reported high risks. The risk for a sibling to a person with multiple sclerosis for developing disease was seven times higher compared to the general population, while the risk for a child of an MS patient was five times higher. The study found no increase in risk for grandchildren and nieces/nephews.

"The population registers in Sweden are reliable tools for finding relatives to MS patients and their possible MS diagnosis, instead of relying on the patients' memories. Our study is a good example of how one can quickly achieve more reliable results than the previous studies that were based on patient groups collected in hospitals throughout decades," says Helga Westerlind, PhD student at the Department of Clinical Neuroscience and first author of the article.

The researchers have also used the Swedish twin register to identify twins with multiple sclerosis and investigate how genes, shared environment and individual risk factors contribute to the disease. The analysis confirmed previous results: MS seems to be primarily caused by genetic factors, and secondarily by individual risk factors. A shared environment does not appear to be of any significance.


'/>"/>
Contact: Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Related biology news :

1. Modest alcohol intake associated with less inflammation in patients with common liver disease
2. Genetic mutation found in familial chronic diarrhea syndrome
3. Evidence of familial vulnerability for epilepsy and psychosis
4. Reproductive health providers should discuss environmental exposure risks with patients
5. Report presents designs for study of cancer risks near US nuclear facilities
6. Increasing water scarcity in Californias Bay-Delta will necessitate trade-offs; hard decisions needed to balance various environmental risks
7. How the ecological risks of extended bioenergy production can be reduced
8. Culturally sensitive research in United Arab Emirates pinpoints indoor air quality risks
9. Growing risks from hatchery fish
10. Updated DHS report on risks of proposed Kansas biocontainment lab
11. Risks and rewards of quantifying natures ecosystem services
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/4/2020)... ... March 04, 2020 , ... ... CEOs to apply to the MedTech IGNITE program’s 2020 IGNITE Cohort. The MedTech ... curriculum to attract and nurture the next generation of medtech founders and entrepreneurs. ...
(Date:3/3/2020)... ... March 03, 2020 , ... Board-certified oral and maxillofacial surgeon, Dr. Michael ... years of training and experience, Dr. Noffze can successfully extract problem and impacted wisdom ... as possible is beneficial to the oral and overall health of most patients as ...
(Date:3/2/2020)... ... March 02, 2020 , ... Rigaku Corporation is ... Chemistry and Applied Spectroscopy ( Pittcon 2020 ), being held March 1 - ... conference and exposition on laboratory science, attracting attendees from industry, academia and government ...
Breaking Biology News(10 mins):
(Date:4/7/2020)... ... April 06, 2020 , ... Red Nucleus, a leading provider ... announced the release of at-home virtual learning resources for all client partners. , ... safety of our employees as we continue to implement measures to safeguard the ...
(Date:4/1/2020)... , ... March 31, 2020 , ... Carterra® Inc., the ... Immunology (LJI), announced today that they will use Carterra’s proprietary LSA™ platform to screen ... to the clinic as early as this summer. , La Jolla Institute for ...
(Date:3/19/2020)... FREDERICK, Md. (PRWEB) , ... ... ... announces a clinical supply and manufacturing collaboration agreement with pioneering gene circuit ... gene-modified cell therapies for ovarian cancer and other solid tumor indications. The ...
(Date:3/10/2020)... RARITAN, N.J. (PRWEB) , ... March 10, 2020 , ... ... saving lives through innovative laboratory solutions, announced its ORTHOTM Sera, ID-MTS, a suite of ... need of transfusion, is cleared to run on ORTHO VISION® and ORTHO VISION® Max ...
Breaking Biology Technology: