Navigation Links
Moderate use averts failure of type 2 diabetes drugs in animal model
Date:10/27/2008

Drugs widely used to treat type 2 diabetes may be more likely to keep working if they are used in moderation, researchers at Washington University School of Medicine in St. Louis have found in a study using an animal model.

The drugs, sulfonylureas, help type 2 diabetics make more insulin, improving control of blood sugar levels. But in most patients the effects of sulfonylureas are lost after several years of use, causing insulin secretion to shut down. This typically forces patients to switch to regular insulin injections.

"Why this happens isn't clear yet, but we've found what may be cause for hope," says senior author Colin G. Nichols, Ph.D., the Carl F. Cori Professor and professor of cell biology and physiology. "We've shown in a mouse model that whatever causes this shutdown doesn't kill the insulin-making beta cells of the pancreas or stop them from making insulin. Instead, it somehow stops them from secreting insulin."

When they stopped receiving the drug, beta cells began secreting insulin again hours later. Nichols and co-author Maria Sara Remedi, Ph.D., instructor of cell biology and physiology, report the findings in Public Library of Science Medicine.

"I find these experimental observations very exciting," says Alan Permutt, M.D., professor of medicine and of cell biology and physiology. "But I'm very cautious that patients understand that the relevance of this model to human diabetes and its treatment still needs to be tested."

If human beta cells also survive and can continue to produce insulin after long-term sulfonylurea exposure, it may be possible to rethink treatment strategies, Nichols suggests.

"Doctors now prescribe new long-acting sulfonylureas to establish a chronic presence of the drug in the bloodstream," he says. "But it may be beneficial to use the older drugs that go away more quickly, allowing the beta cells time to recover."

Another potential option would be a
'/>"/>

Contact: Michael Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Moderate prenatal exposure to alcohol and stress in monkeys can cause touch sensitivity
2. Moderate quantities of dirt make more rain
3. High blood pressure, low energy -- a recipe for heart failure
4. Certain diseases, birth defects may be linked to failure of protein recycling system
5. Genetic variant mimics effect of heart failure medications
6. Many African-Americans have a gene that prolongs life after heart failure
7. Jefferson receives $11.6M NIH grant to study novel mechanisms of heart failure
8. Oocyte-specific gene mutations cause premature ovarian failure
9. Vitamin D: New way to treat heart failure?
10. Failure to bridle inflammation spurs atherosclerosis
11. Failure of the 1st attempt at assisted reproduction justifies at least 1 additional cycle
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... inevitable consequence of aging? , Although it is widely ... the risk of developing several common cancers decreases with ... apparent decrease with age in the risk of developing ... this puzzle was presented in a recent paper published ... James P. Brody of the Department of Biomedical Engineering ...
(Date:7/14/2014)... developed a technology that could overcome a major ... a fuel that could replace expensive and environmentally ... a novel catalyst that performs almost as well ... use electric currents to split water molecules into ... far more efficient than less-expensive catalysts investigated to-date. ...
(Date:7/13/2014)... French . , ... led by the Research Institute of the McGill University ... oral medication is showing significant progress in restoring vision ... this inherited retinal disease that causes visual impairment ranging ... The study is published today in the scientific journal ...
Breaking Biology News(10 mins):Rutgers chemists develop technology to produce clean-burning hydrogen fuel 2MUHC researcher unveils novel treatment for a form of childhood blindness 2
... early stages, prostate cancer requires androgens (hormones that promote ... growth, and current first-line therapies target the receptor for ... However, advanced prostate cancers are often androgen-independent, ... sure how this shift occurs as prostate cancer advances. ...
... JERUSALEM , July 6, 2010 IDenta Corp.,(PINKSHEETS: IDTA) CEO Yaacov Shoham ... The IDenta,s BTK- Bullet Hole ... , , ... , http://www.lasvegassun.com/news/2008/jul/08/gee-whiz-packed-metro-csi-tru , ...
... just yet, but if you,re taking antioxidants because you hope ... the June 2010 issue of the journal GENETICS ... stress to our tissues shortens lifespan. That,s because researchers from ... genes of worms (genes believed to have counterparts in humans) ...
Cached Biology News:UNC team finds new target for treatment of advanced prostate cancer 2International Drug & Explosives Detection Company IDenta Corp Reports on BTK- Bullet Hole Testing Kit 2International Drug & Explosives Detection Company IDenta Corp Reports on BTK- Bullet Hole Testing Kit 3Want to slow aging? New research suggests it takes more than antioxidants 2
(Date:7/10/2014)... Unraveling life’s mysteries can intrigue, amaze, ... Family purchased a DNA test to unravel ... with a lifetime of memories, sharing, and closeness. In ... DNA genuinely brought the family closer together. , ... genetic history and prior to taking the genetic ...
(Date:7/10/2014)... Angeles, CA (PRWEB) July 10, 2014 ... and Bioanalytical techniques during 18-20 August, 2014 at Double ... critically review the recent developments in Analytical & Bioanalytical ... the globe. , Speaking on this occasion, Dr. Srinubabu ... Analytica Acta conference is a remarkable one in ...
(Date:7/10/2014)... Senior supply chain management executives from over ... challenges of “Reducing Cost, Lead Time, & Defects in ... Describing the partnership of the Bio Supply Management Alliance ... ( SCMI) of the University of San Diego ... Kroc Institute of Peace and Justice in San Diego, ...
(Date:7/10/2014)... On July 9 Prime Minister ... Russia,s first national "Industry" award ... is developing a unique project called MabNext . ... number of innovative drugs based on monoclonal antibodies for ... place at the International Exhibition "Innoprom 2014" in Ekaterinburg. ...
Breaking Biology Technology:Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2
... software developer Cedara Software and the ... to offer Cedara B-CAD to its customers as part ... Workstation. , ,Cedara B-CAD is a Computer Aided Detection ... lesions using ultrasound images, providing tools for automatic image ...
... individuals are invited to enter the 35th ... benefits coming from research and engineering of new ... Products Awards are given in four major categories: ... (500-999 employees); medium companies (50-499 employees); and small ...
... StrandVision , latest business venture of Mike Strand in ... last business-plan competition, has landed $250,000 from the ... Online Kiosks, has a plan to put video screens ... After reaching the statewide business-plan competition finals, it won ...
Cached Biology Technology: