Navigation Links
Modeling cancer using ecological principles
Date:10/2/2011

The invasion of a new species into an established ecosystem can be directly compared to the steps involved in cancer metastasis. New research published in BioMed Central's open access journal Theoretical Biology and Medical Modelling uses the Tilman model of competition between invasive species to study the metastasis of prostate cells into bone.

Approximately 40,000 men a year in the US who have apparently successful surgery or radiotherapy for prostate cancer will suffer incurable metastasis of their disease in bone. The prostate cells invade the bone marrow and, sometimes after years of remaining dormant, compete with hematopoietic stem cells and take over the bone microenvironment.

The Tilman model examines various components of invasion of species into an environment. Kun-Wan Chen and Kenneth J. Pienta from the University of Michigan substituted steps in cancer progression into the Tilman equations. After initially multiplying and undergoing genetic mutation (equivalent to evolution) within the prostate, the cancer cells leave the prostate and enter the circulation. The next step is a period of survival in circulation followed by invasion into bone.

Once in the bone there is a 'lag period' while the cells establish themselves. Eventually, the cancer cells begin to multiply and out-compete the hematopoietic stem cells. Kun-Wan Chen explained, "The invading cancer cells could be thought of as several species, and the fittest mutants become dominant and multiply. Eventually there is a massive impact on the biosphere (human host)."

Prof Pienta continued, "Devastating ecological invasions are well known. For example introduction of domestic animals to Mauritius resulted in extinction of the dodo and Caulerpa taxifolia, a mutated killer algae, is plaguing the Mediterranean. Cancer metastasis follows a similar path to that of ecological invasions and our adaptation of the Tilman equations shows how invading cancer ce
'/>"/>

Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-020-319-22370
BioMed Central
Source:Eurekalert

Page: 1 2

Related biology news :

1. Research discovers frequent mutations of chromatin remodeling genes in TCC of the bladder
2. Modeling plant metabolism to optimize oil production
3. DOE grant joins climate modeling with local, regional empirical data
4. Malaria modeling and control focus of workshop
5. Consortium studying mathematical modeling of influenza infection
6. OSU, Oxford, others launch citizen scientist climate modeling initiative
7. Tutorial addresses stochastic modeling in biological process
8. Modeling study identifies characteristics of high elk-use areas in western Oregon, Washington
9. Colorado State University scientist simplifies aerosols for modeling
10. Modeling reef ecosystems focus of workshop
11. Modeling Toxoplasma focus of workshop
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... N.C. , Dec. 9, 2014  Valencell, a ... it is seeing a staggering demand from its licensees ... the Company revealed, is not solely coming from fitness ... as well. "A wearable is only as ... result, accuracy is the ultimate driver in long-term mass ...
(Date:12/10/2014)... , Dec. 08, 2014 Research and Markets ... addition of the "Biometrics Market in Japan ... http://photos.prnewswire.com/prnh/20130307/600769 The ... such as rural banking and upgradation of the ... witnessed in the market. Besides the aforementioned projects, ...
(Date:12/5/2014)... 4, 2014  Tute Genomics, a leader in cloud-based ... Series A1 funding led by UK-based Eurovestech. Peak Ventures ... the investment round. "We are at a ... next-generation sequencing and seeks new approaches for the diagnosis, ... , MD MBA, and CEO of Tute Genomics. "One ...
Breaking Biology News(10 mins):Wearable Technology Products Demand Highly Accurate Biometric Technology 2Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3
... a gene implicated in human cancers, researchers from Whitehead Institute ... online issue of Science. , MicroRNAs are tiny snippets of ... the gene's messenger RNA (which copies DNA information and starts ... microRNA was discovered in 1993, in worms. It took seven ...
... digest cellulose, but the human process of producing ethanol ... is the sluggish rate at which the cellulose enzyme ... are then fermented into ethanol. , To help unlock ... molecular simulations at the San Diego Supercomputer Center (SDSC), ...
... parents, 8 million cases of acute middle ear infections every ... trips to the pediatrician. But new research from a collaboration ... all that. , In the March 23 issue of ... Jude show that middle ear infections in mice can be ...
Cached Biology News:MicroRNA helps prevent tumors 2MicroRNA helps prevent tumors 3Meeting the ethanol challenge: Scientists use supercomputer to target cellulose bottleneck 2Meeting the ethanol challenge: Scientists use supercomputer to target cellulose bottleneck 3Viral protein is an effective preventative against infection 2
(Date:12/19/2014)... 2014 iLab Solutions, the global leader ... Siri Bryant as the new Director of Institutional Implementations ... Implementations. These two new leadership positions were created to ... ensuring that iLab continues to meet the needs of ... years, iLab has been deployed at over 450 core ...
(Date:12/19/2014)... , Dec. 18, 2014  Decision Resources Group finds ... biomaterial market will grow moderately through 2023 as the ... growing awareness of dental biomaterials all spur procedure volumes. ... as China and ... dental procedures within reach for a larger proportion of ...
(Date:12/17/2014)... 16, 2014 The Activated Carbon ... which is why IBISWorld updated its original industry research ... benefit from an intensified focus on environmental policy. Over ... emission standards for power plants and a range of ... IBISWorld Industry Analyst Sarah Kahn, “a range of downstream ...
(Date:12/17/2014)... Ipsen Biopharmaceuticals, Inc., an affiliate ... IPSEY), today announced that Somatuline® Depot® (lanreotide) ... approved by the U.S. Food and Drug Administration ... (GEP-NETs) in adult patients with unresectable, well or ... improve progression-free survival (PFS). , “The approval of ...
Breaking Biology Technology:iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 3Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 2Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 3Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 2Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 3Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 4Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 5Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 6Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 7Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 8
... Feb. 6, 2012  Auxilium Pharmaceuticals, Inc. (Nasdaq: ... announced the appointment of two executive officers, effective ... Vice President, Chief Administrative Officer and General Counsel, ... Vice President, Sales. "The leadership appointments ...
... 2012 Ikaria, Inc., a critical care company focused on ... needs of critically ill patients in the hospital and ICU ... will present at the 14th Annual BIO CEO & Investor ... 13, 2012 at 3:30 p.m. EST in the Park South ...
... , a Manchester team lead by Nobel laureates Professor Andre ... dimension in graphene research. Their research shows a transistor that ... next silicon. Graphene one atomic plane of ... from electronic to chemical and from optical to mechanical. ...
Cached Biology Technology:Auxilium Announces Appointments to Enhance Leadership Team 2Auxilium Announces Appointments to Enhance Leadership Team 3Auxilium Announces Appointments to Enhance Leadership Team 4Auxilium Announces Appointments to Enhance Leadership Team 5Ikaria® to Present at 14th Annual BIO CEO & Investor Conference 2Graphene electronics moves into a third dimension 2
Mouse monoclonal antibody raised against a partial recombinant QARS. NCBI Entrez Gene ID = QARS...
96-well format (For processing samples on microplate-size MALDI target plates such as those from Bruker, Shimadzu, Thermo, and PerkinElmer) Packaging: 2 / pack...
... mixing devices. Stepping motors device is maintenance ... durable shaker to provide a uniform motion ... nature. Regulated action scale for all modes. ... control time, continuous time, action scale and ...
Mouse monoclonal antibody raised against a partial recombinant STAU2. NCBI Entrez Gene ID = STAU2...
Biology Products: