Navigation Links
Model tissue system reveals cellular communication via amino acids
Date:4/3/2009

A team of researchers from the Massachusetts General Hospital Center for Engineering in Medicine (MGH-CEM) has found the first evidence of cell-to-cell communication by amino acids, the building blocks of proteins, rather than by known protein signaling agents such as growth factors or cytokines. Their report will appear in an upcoming issue of the FASEB Journal and has been released online.

"We were taken by complete surprise," says Rohit Jindal, PhD, a postdoctoral fellow at MGH-CEM and the paper's lead author. "Past reports have implicated various growth factors and the extracellular matrix proteins secreted by other cell types in regulating hepatocyte behavior, but to the best of our knowledge, this is the first evidence that cells can communicate by changing local amino acid concentrations."

The authors describe the development of a three-dimensional model of liver tissue in which hepatocytes (liver cells) are embedded in a layer of collagen and covered with a layer of endothelial cells the cells that line blood vessels, which permeate the liver. In this model system liver cells recovered their metabolic activity much faster than in previous models in two days instead of a week or longer. The fundamental discovery was that the amino acid proline was responsible for this enhanced recovery. A building block of collagen, proline was secreted by the endothelial layer of the liver model, taken up by hepatocytes and used to synthesize new collagen, leading to faster recovery of hepatocyte activity.

"Identifying this amino-acid-mediated communication points to the importance of considering changes in metabolism while evaluating cell-to-cell communication," says Martin Yarmush, MD, PhD, director of the MGH-CEM and the paper's senior author. "Metabolic factors are gaining prominence in our understanding of a number of diseases, and establishing the contribution of different cell types to the metabolic milieu could provide
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. CSHL team develops mouse models of leukemia that predict response to chemotherapy
2. Disease Models & Mechanisms -- selected for indexing in Medline
3. New models question old assumptions about how many molecules it takes to control cell division
4. Calculating gene and protein connections in a Parkinsons disease model
5. A revolutionary new model for Alzheimers disease
6. Veterinarians developing model to help producers, vets make cattle more comfortable
7. Artificial cells, simple model for complex structure
8. Bacteria are models of efficiency
9. Research model may one day inoculate elderly against slip-related falls
10. Discovery could lead to a new animal model for hepatitis C
11. David Rose to present Howe School lecture on new technologies and business models, Jan. 29
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2014)... In one of the largest prevalence studies to date, ... genotype prevalence estimates for the hepatitis C virus (HCV). ... Association for the Study of Liver Diseases, indicate that ... 83 million patients infected of which one-third reside in ... cases, is the next most prevalent, followed by genotypes ...
(Date:7/27/2014)... RESEARCH UK scientists at Barts Cancer Institute have found ... cancer therapy significantly more effective, according to research published ... Barts Cancer Institute, part of Queen Mary University of ... kinase (FAK), signals the body to repair itself after ... DNA. When the researchers removed FAK from blood vessels ...
(Date:7/25/2014)... Before the colonial era, 100,000s of people lived on ... cultures manipulated fire to control the availability of plants ... tribes continue to use fire to maintain desired habitat ... the U.S. Forest Service,s Pacific Southwest Station, will lead ... National Wildfire Refuge during the Ecological Society of America,s ...
Breaking Biology News(10 mins):Hepatitis C virus genotype 1 is most prevalent worldwide 2New drug target can break down cancer's barrier against treatment 2Fire ecology manipulation by California native cultures 2Fire ecology manipulation by California native cultures 3
... the University of Maryland Center for Environmental Science ... a lack of predators and competitors was the ... dogfish observed in Southern New Englands Georges Bank ... 1980s. In an article appearing in the ...
... a new environment while others do not" Scientists from ... headway on this question after analyzing how fast cane ... 70 years of data on toad presences collected since ... regions of Australia at dramatically divergent rates. These variable ...
... Arenas, Chile, on the tip of South America, to spend ... Southern Ocean. Here they hope to make groundbreaking measurements to ... and sea, and vice-versa. The cruise, ... the greenhouse gas carbon dioxide moves between the ocean and ...
Cached Biology News:Researchers offer new theory for dogfish and skate population outburst on George's Bank 2Voyage to Southern Ocean aims to study air-sea fluxes of greenhouse gases 2
(Date:7/28/2014)... YORK , July 28, 2014  David ... ConvergeHEALTH by Deloitte , has been elected ... Interchange Standards Consortium, a non-profit working to establish ... data, particularly as it relates to electronic health ... continue CDISC,s mission of collaborating with organizations across ...
(Date:7/28/2014)... July 28, 2014 It’s a hard truth: ... benefits to further their post-secondary education are failing to obtain ... released this year. And according to an analysis by ... is veteran students’ uninformed choice of college majors, which leads ... of the study: Some 51.7 percent of post-9/11 veterans using ...
(Date:7/28/2014)... DUBLIN , July 28, 2014 Research ... "Global Particle Size Analysis Market 2014-2018" report to their ... Particle size analysis is a technique used to determine ... powder or liquid. It is crucial to analyze the size ... material. Therefore, particle size analysis is performed to determine the ...
(Date:7/25/2014)... 25, 2014 Amgen (NASDAQ: AMGN ... a $0.61 per share dividend for the third quarter ... 5, 2014, to all stockholders of record as of ... About Amgen Amgen is committed to unlocking ... illnesses by discovering, developing, manufacturing and delivering innovative human ...
Breaking Biology Technology:ConvergeHEALTH by Deloitte's David Hardison Named Chairman of the Clinical Data Interchange Standards Consortium 2ConvergeHEALTH by Deloitte's David Hardison Named Chairman of the Clinical Data Interchange Standards Consortium 3Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 2Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 3Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 4Global Particle Size Analysis Market 2014-2018 2Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3
... today announced the receipt of a two-year Small Business ... the National Institute on Aging, National Institutes of Health ... antibodies targeting tau protein oligomers in the development of ... be screened at the Michigan High Throughput Screening Center ...
... Wound Management Technologies, Inc., (OTC Bulletin Board: ... solutions, announced today that its President, Deborah Jenkins Hutchinson, ... product, CellerateRX®, recent strategic developments, and its product pipeline ... be held at the JW Marriott Marquis Miami on ...
... a way to overcome one of the main limitations of ... Everyone who has had an ultrasound, including most pregnant women, ... of the limits to the detail obtainable with sonography is ... dictate that the smallest objects you can "see" are about ...
Cached Biology Technology:Oligomerix, Inc. Awarded Phase II NIH Grant to Discover Novel Drugs for Alzheimer's Disease 2Wound Management Technologies to Present at LifeTech Capital Miami Medical Investors Conference 2Novel metamaterial vastly improves quality of ultrasound imaging 2