Navigation Links
Model may offer better understanding of embryonic development
Date:3/9/2010

WEST LAFAYETTE, Ind. - A mathematical model developed at Purdue University can predict complex signaling patterns that could help scientists determine how stem cells in an embryo later become specific tissues, knowledge that could be used to understand and treat developmental disorders and some diseases.

During embryonic development, proteins attach to cell receptors and start a cascade of reactions. Understanding those reactions is difficult, however, because feedback signals go back out to the proteins or other molecules along the cascade, constantly changing the reaction pattern. The outcomes of those reactions and the feedback mechanisms - or inputs - are known because they can be observed, but how the inputs lead to the outputs isn't understood.

"We want to understand how stem cells become tissue-specific so that we can manipulate that process to create cells that could be used to treat injuries and diseases," said David Umulis, a Purdue assistant professor of agricultural and biological engineering. "Using a model approach, we can simulate these complex signaling patterns to get a better handle on the process."

Umulis created a model that predicted accurate outcomes when different feedback mechanisms were inserted. His results were published in the current issue of the journal Developmental Cell.

"Fruit fly embryos are a fantastic system to peer into early development since input/output relationships are easy to observe. You have a mutation and an output, but we don't typically know what happens in the middle," he said. "Realistic model embryos proved an additional tool that can be used to aid in that understanding. Models can link that cause and effect."

The study looked at fruit fly, or drosophila, embryos during very early development to decipher what controls the differentiation of these stem cells at their proper locations. During the process, cells take on identities that later specify tissue types
'/>"/>

Contact: Brian Wallheimer
bwallhei@purdue.edu
765-496-2050
Purdue University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
2. A new kind of rat model
3. JILA finds flaw in model describing DNA elasticity
4. Smithsonian researchers develop models to assess wetland health
5. Prediction of RNA pseudoknots using heuristic modeling with mapping and sequential folding
6. Simulating kernel production influences maize model accuracy
7. MIT model could improve some drugs effectiveness
8. Model for the assembly of advanced, single-molecule-based electronic components developed at Pitt
9. Improving detection of nuclear smuggling goal of computer model of mechanical engineer
10. New chimeric mouse model for human liver diseases, drug testing
11. Study finds first-ever genetic animal model of autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... 22, 2014  NXT-ID, Inc. (NASDAQ: NXTD and ... on the growing mobile commerce market, announces it has retained ... for the 2015 International CES debut of the Wocket™ biometric ... be at the NXT-ID booth January 6th and 7 th ...
(Date:12/19/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ) ... Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology ... http://photos.prnewswire.com/prnh/20130307/600769 Following the acquisition ... reading feature with the iPhone 5S. It is currently ...
(Date:12/19/2014)... Dec. 18, 2014   LaunchKey , the first decentralized ... and Internet of Things era, today announced the close ... round was led by Metamorphic Ventures with participation from ... VegasTechFund, and others.  LaunchKey has raised $4 million to ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3
... in utero opioid exposure), variants in certain genes were associated ... for treatment, preliminary findings that may provide insight into the ... 1 issue of JAMA , a theme issue on ... Hospital for Children at Tufts Medical Center, Boston, presented the ...
... led by Northwestern Medicine scientists has identified how a defective ... disease known as Giant Axonal Neuropathy, or GAN. The finding ... Investigation . GAN is an extremely rare and ... systems of young children. Those affected show no symptoms at ...
... , April 29, 2013 Research ... "Gesture Recognition & Touchless Sensing Market (2013 ... Capacitive); Product (Biometric, Sanitary Equipment); Application (Healthcare, Consumer ... report to their offering.      (Logo: ...
Cached Biology News:Study examines effects of genetic variants for infants with neonatal abstinence syndrome 2Rare, lethal childhood disease tracked to protein 2Gesture Recognition & Touchless Sensing Market (2013 - 2018): By Technology, Product, Application and Geography 2Gesture Recognition & Touchless Sensing Market (2013 - 2018): By Technology, Product, Application and Geography 3
(Date:1/23/2015)... Biofertilizers stimulate microbial activities in soil. These microorganisms generate ... activities in the soil or in the rhizosphere. The ... on reducing environmental pollution and on reducing the usage ... the bio fertilizers market with analysis and forecasting of ...
(Date:1/22/2015)... California (PRWEB) January 22, 2015 Eckert ... Accelerator Mass Spectrometry (AMS) services to the pharmaceutical and ... has joined the company in the position of Director ... years of broad and valuable experience in drug metabolism ...
(Date:1/22/2015)... NH (PRWEB) January 22, 2015 GEA ... a table top laboratory homogenizer, the PandaPLUS 2000, which ... nanodispersions, nanoemulsions , and cell disruption . This ... dairy products, fruit juices, liquid food, food additives and ...
(Date:1/22/2015)... The laboratory information management systems market ... number of technological advancements due to factors such as ... to integrate healthcare systems, and increasing government support for ... integration. Key players in the market focus on technological ...
Breaking Biology Technology:Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 2Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 3Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 4Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 2Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 3GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 4
... As ... ... as other commercial real estate sectors struggle, investors continue to pour hundreds of millions ... new debt and $30 million in new equity from Prudential Real Estate Investors (PREI), ...
... , SAN DIEGO, July 30 ... plans to develop a DNA-based orthobiologics product portfolio based on ... initially focus on non-union bone fractures for medically-compromised patients, and ... is a rapidly growing segment of the orthopedics market and ...
... PDI, Inc. (Nasdaq: PDII ), a leading provider of ... PDI director Gerald P. Belle has been appointed to the newly-established position ... has been a director of the Company since April 2008. He is ... "Jerry has served as an invaluable board member during his tenure with ...
Cached Biology Technology:Millions Flowing into Medical Real Estate 2Millions Flowing into Medical Real Estate 3Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors 2Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors 3Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors 4Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors 5Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors 6Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors 7Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors 8Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors 9Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors 10PDI Appoints Gerald P. Belle as Lead Independent Director 2PDI Appoints Gerald P. Belle as Lead Independent Director 3
... Printing Surface (3 glass slides coated with 100 /500/1000 ... wafer coated with 1000 Angstroms of Gold over TI ... Stamps (3 PDMS micropatterned stamps with series of 100 ... mm or 200 um x 10 mm lines, 3 ...
Mouse VEGF R1/Flt-1 Phycoerythrin MAb (Clone 141522) Keywords: Receptor Tyrosine Kinase, RTK, VEGFR1, VEGF Receptor 1 Protein Family: Receptor Tyrosine Kinases, VEGF/PDGF Family...
Affinity Purified Anti-Human NP-1...
Mouse Anti-Amyloid beta [1-16], clone 6E10, Monoclonal Antibody...
Biology Products: