Navigation Links
Model may offer better understanding of embryonic development

WEST LAFAYETTE, Ind. - A mathematical model developed at Purdue University can predict complex signaling patterns that could help scientists determine how stem cells in an embryo later become specific tissues, knowledge that could be used to understand and treat developmental disorders and some diseases.

During embryonic development, proteins attach to cell receptors and start a cascade of reactions. Understanding those reactions is difficult, however, because feedback signals go back out to the proteins or other molecules along the cascade, constantly changing the reaction pattern. The outcomes of those reactions and the feedback mechanisms - or inputs - are known because they can be observed, but how the inputs lead to the outputs isn't understood.

"We want to understand how stem cells become tissue-specific so that we can manipulate that process to create cells that could be used to treat injuries and diseases," said David Umulis, a Purdue assistant professor of agricultural and biological engineering. "Using a model approach, we can simulate these complex signaling patterns to get a better handle on the process."

Umulis created a model that predicted accurate outcomes when different feedback mechanisms were inserted. His results were published in the current issue of the journal Developmental Cell.

"Fruit fly embryos are a fantastic system to peer into early development since input/output relationships are easy to observe. You have a mutation and an output, but we don't typically know what happens in the middle," he said. "Realistic model embryos proved an additional tool that can be used to aid in that understanding. Models can link that cause and effect."

The study looked at fruit fly, or drosophila, embryos during very early development to decipher what controls the differentiation of these stem cells at their proper locations. During the process, cells take on identities that later specify tissue types in the adult organism. Before directional cues dictate development, the stem cells are capable of becoming many different tissues. Using models to analyze the dynamic signals the cells are receiving may help to better understand how to control similar cells in a laboratory setting.

Umulis said his model is a sort of template to allow researchers to test a number of hypotheses before conducting actual experiments. The information garnered from realistic 3-D models can guide the process and facilitate rapid discovery.

Umulis' next step is to count the number of molecules needed to initiate specific cell responses during embryonic development. The National Institutes of Health and Purdue University funded his work.


Contact: Brian Wallheimer
Purdue University

Related biology news :

1. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
2. A new kind of rat model
3. JILA finds flaw in model describing DNA elasticity
4. Smithsonian researchers develop models to assess wetland health
5. Prediction of RNA pseudoknots using heuristic modeling with mapping and sequential folding
6. Simulating kernel production influences maize model accuracy
7. MIT model could improve some drugs effectiveness
8. Model for the assembly of advanced, single-molecule-based electronic components developed at Pitt
9. Improving detection of nuclear smuggling goal of computer model of mechanical engineer
10. New chimeric mouse model for human liver diseases, drug testing
11. Study finds first-ever genetic animal model of autism
Post Your Comments:
(Date:4/28/2016)... 2016 First quarter 2016:   ... with the first quarter of 2015 The gross margin ... (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) , ... unchanged, SEK 7,000-8,500 M. The operating margin for 2016 ...
(Date:4/19/2016)... -- The new GEZE SecuLogic access control ... system solution for all door components. It can be ... interface with integration authorization management system, and thus fulfills ... dimensions of the access control and the optimum integration ... considerable freedom of design with regard to the doors. ...
(Date:4/14/2016)... Israel , April 14, 2016 ... Authentication and Malware Detection, today announced the appointment of ... assumed the new role. Goldwerger,s leadership appointment ... on the heels of the deployment of its platform ... BioCatch,s behavioral biometric technology, which discerns unique cognitive and ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... ... innovative medical technologies, services and solutions to the healthcare market. The company's primary ... various distribution, manufacturing, sales and marketing strategies that are necessary to help companies ...
(Date:6/24/2016)... , June 24, 2016  Regular discussions on a ... take place between the two entities said Poloz. ... Ottawa , he pointed to the country,s ... the federal government. ... said, "Both institutions have common economic goals, why not sit ...
(Date:6/23/2016)... WA (PRWEB) , ... June 23, 2016 , ... ... announces the release of its second eBook, “Clinical Trials Patient Recruitment and Retention ... recruitment and retention in this eBook by providing practical tips, tools, and strategies ...
(Date:6/23/2016)... June 23, 2016 A person commits a crime, ... scene to track the criminal down. An outbreak ... and Drug Administration (FDA) uses DNA evidence to track down ... Sound far-fetched? It,s not. The FDA has increasingly used ... investigations of foodborne illnesses. Put as simply as possible, whole ...
Breaking Biology Technology: