Navigation Links
Mobilizing white blood cells to the lung: New discovery could lead to an improved influenza vaccine
Date:7/10/2008

July, 10, 2008; Saranac Lake, N.Y. -- Findings just published in the scientific journal Immunity by researchers at the Trudeau Institute shed new light on how a previously-unknown messaging mechanism within the human immune system prompts specific influenza-fighting cells to the lung airways during an infection.

Infections from the influenza virus are responsible for hundreds of thousands of hospitalizations and as many as 40,000 deaths in the United States each year. Although researchers have known for some time that white blood cells congregating in the lung and directly attacking the virus play an important role in defending against influenza, it has never been clear how exactly these white blood cells know when they are required in the lung.

Now new research in the Trudeau Institute laboratory of Dr. David Woodland offers important insights into the navigational aids used by these cells as they maneuver through the human body. Trudeau investigators have shown that lungs which have been infected with the influenza virus produce a series of chemicals, or chemokines, which act as beacons for specific types of white blood cells. While circulating in the bloodstream, these white blood cells recognize the chemical messages signaling the presence of the virus and the need for them to move into lung tissues.

According to Dr. Woodland, director of the Trudeau Institute and lead researcher on the project: An important aspect of these findings is that this response occurs early in the disease process, typically within a couple of days of the initial infection. It also turns out that only a fraction of the available white blood cells are capable of recognizing these chemokine messages. Discovering that this response occurs rapidly, and that only a specific subset of white blood cells can recognize these messages, helps provide important new information for researchers working towards developing better a better influenza vaccine.


'/>"/>

Contact: Brian Turner
bturner@trudeauinstitute.org
518-891-3080
Trudeau Institute
Source:Eurekalert

Related biology news :

1. GBIF sets goal of mobilizing 1 billion records by end of 2008
2. Known genetic risk for Alzheimers in whites also places blacks at risk
3. White House science office needs upgrade
4. Clumps of red and white blood cells may contribute to sickle cell disease
5. New whitepaper offers options for university implementation of NIH policy
6. Unveiling the underwater ways of the white shark
7. ESA honored at White House ceremony
8. Counting tumor cells in blood predicts treatment benefit in prostate cancer
9. New technology enhances therapeutic potential of cord blood stem cells
10. Natural compounds in cocoa tied to blood flow improvements for adults with type 2 diabetes
11. New cell-based sensors sniff out danger like bloodhounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... 2016 Perimeter Surveillance & Detection ... Physical Infrastructure, Support & Other Service  The ... offers comprehensive analysis of the global Border Security ... revenues of $17.98 billion in 2016. Now: ... leader in software and hardware technologies for advanced video ...
(Date:5/16/2016)...   EyeLock LLC , a market leader of ... an IoT Center of Excellence in Austin, ... of embedded iris biometric applications. EyeLock,s iris ... security with unmatched biometric accuracy, making it the most ... EyeLock,s platform uses video technology to deliver a fast ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 /PRNewswire/ ... product subsidiary of Infosys (NYSE: INFY ), and ... global partnership that will provide end customers with ... banking and payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ... area for financial services, but it also plays a fundamental ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only ... Center and will showcase its product’s latest features from June 26 to June ... scientific poster on Disrupting Clinical Trials in The Cloud during the conference. ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... of intelligent tools designed, tuned and optimized exclusively for Okuma CNC machining centers ... The result of a collaboration among several companies with expertise in toolholding, cutting ...
(Date:6/23/2016)... June 23, 2016 ReportsnReports.com ... report to its pharmaceuticals section with historic and ... and much more. Complete report on ... pages, profiling 15 companies and supported with 261 ... http://www.reportsnreports.com/reports/601420-global-cell-culture-media-industry-2016-market-research-report.html . The Global Cell ...
(Date:6/22/2016)... Research and Markets has announced the addition of the "Biomarkers: ... The global biomarkers market has grown ... market is expected to grow at a five-year compound annual growth ... billion in 2015 to $96.6 billion in 2020. ... 2020) are discussed. As well, new products approved in 2013 and ...
Breaking Biology Technology: