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Mobilizing the repair squad: Critical protein helps mend damaged DNA
Date:12/24/2009

ata, we predict that mutations to the DR domain would lead to cancer," he says.

In the long term, the team hopes that a better understanding of the DNA damage pathway may provide clues for cancer treatment in the future. "CtIP is another important player in the double-strand break response," says Hunter. "We have added another piece to the complex puzzle of DNA repair."

Along with Drs. Hunter and You, researchers who contributed to the work include Linda Shi, Ph.D. , and Andrew Basilio at the University of California, San Diego; Quan Zhu, Ph.D., Nina Tonnu, and Inder Verma, Ph.D. in the Salk Institute's Laboratory of Genetics; Peng Wu, Ph.D., in You's lab at Washington University School of Medicine; You-Wei Zhang, Ph.D. , now at Case Western Reserve University; and Michael W. Berns, Ph.D., at UCSD and University of California, Irvine.


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Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-410-01340
Salk Institute
Source:Eurekalert

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