Navigation Links
Mobilizing the repair squad: Critical protein helps mend damaged DNA
Date:12/24/2009

La Jolla, CAIn order to preserve our DNA, cells have developed an intricate system for monitoring and repairing DNA damage. Yet precisely how the initial damage signal is converted into a repair response remains unclear. Researchers at the Salk Institute for Biological Studies have now solved a crucial piece of the complex puzzle.

In a forthcoming article in the Dec. 24 issue of Molecular Cell, they show that a protein named CtIP plays an essential role in the DNA damage "signal-to-repair" conversion process. "Being able to repair damaged DNA is extremely important; the cell has to know when it has received this type of damage and respond appropriately," explains Tony Hunter, Ph.D., American Cancer Society Professor in the Molecular and Cell Biology Laboratory and director of the Salk Institute Cancer Center, who led the study. "Failure to do so can have disastrous consequences."

The DNA in our cells is under constant attack from reactive chemicals generated as byproducts of cellular metabolism. In addition, it is assaulted by x-rays, ultraviolet radiation from the sun, and environmental carcinogens such as tobacco smoke. As a result of this continuous bombardment, some studies have estimated that the DNA in a single human cell gets damaged over 10,000 times every day.

If not repaired properly, the damage leads to mutations, which over time can cause cancer. "As a result, individuals with an inherited impairment in DNA repair capability are often at increased risk of cancer," notes first author Zhongsheng You, Ph.D., a former postdoctoral researcher at the Salk Institute and now an assistant professor at Washington University School of Medicine in St. Louis.

DNA consists of two intertwined strands so that when the DNA is broken, two ends are revealed, one from each strand. In order to repair the DNA break, one strand is trimmed awayor resectedlike a loose thread, leaving only the second strand. This exposed strand th
'/>"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-410-01340
Salk Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. GBIF sets goal of mobilizing 1 billion records by end of 2008
2. Mobilizing white blood cells to the lung: New discovery could lead to an improved influenza vaccine
3. Human derived stem cells can repair rat hearts damaged by heart attack
4. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
5. Enzyme alerts cells powerful army to repair DNA damage
6. Seattle Childrens Hospital leads $23.7 million NIH grant to study gene repair
7. Simulation reveals how body repairs balance after damage
8. Using nanotubes to detect and repair cracks in aircraft wings, other structures
9. Enhanced DNA-repair mechanism can cause breast cancer
10. Yale receives $8.4 million to study DNA repair in cancer cells
11. Building the future -- 21st century nano tools to repair the nervous system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... In addition to the hippocampus, the marginal division ... and memory. What is the impact degree of ... learning and memory function? Yan Yu and his ... China found, using immunofluorescence staining, that substance P ... hippocampus and striatal marginal division of normal rats. ...
(Date:7/11/2014)... let nerve cells send out electrical signals, Johns Hopkins ... that may offer a new way to protect crops ... way. , Their findingthat naturally occurring insect toxins ... a closely related onesuggests that insecticides can be designed ... bees. A summary of the research, led by Frank ...
(Date:7/10/2014)... NEW YORK , June 27, 2014 /PRNewswire/ ... against Provectus Biopharmaceuticals, Inc. ("Provectus" or the "Company")(NYSE-MKT: ... action, filed in United States District Court, Middle ... Division, is on behalf of a class consisting ... otherwise acquired Provectus securities between December 17, 2013 ...
Breaking Biology News(10 mins):Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3
... the Entomological Society of America (ESA) features the Linnaean ... a lively question-and-answer, college bowl-style competition on insect facts ... and entertaining component of the ESA Annual Meeting. ... Branches will compete in the national competition this December ...
... Largo, Fla. April 27, 2009 A new study ... for reattaching large sponges that have been dislodged from coral ... of other large sponge species removed by human activities or ... sponge were removed and reattached at Conch Reef off of ...
... 27, 2009) In an in vitro study, led by ... discovered how a protein called SUMO (Small Ubiquitin-related Modifier) ... chromatin to regulate expression of genes. Chromatin is a ... chromosomes. The interaction between SUMO and the enzyme complex ...
Cached Biology News:Entomological Society of America's Linnaean Games teams selected 2Large sponges may be reattached to coral reefs 2SUMO protein guides chromatin remodeler to suppress genes 2
(Date:7/10/2014)... Senior supply chain management executives from over 50 ... of “Reducing Cost, Lead Time, & Defects in the ... the partnership of the Bio Supply Management Alliance ( ... SCMI) of the University of San Diego in ... Institute of Peace and Justice in San Diego, Devendra ...
(Date:7/10/2014)... , July 10, 2014 On ... Dmitry Medvedev , presented Russia,s ... BIOCAD . The Company is developing a unique project ... project BIOCAD develops a number of innovative drugs based ... diseases. The ceremony took place at the International Exhibition ...
(Date:7/10/2014)... July 10, 2014 /PRNewswire-iReach/ -- Tute Genomics, ... today announced an agreement with Lineagen, Inc., ... Lineagen,s NextStep Dx PLUS.  Lineagen, focused ... neurological disorders, currently offers FirstStep Dx ... service used by healthcare providers as a ...
(Date:7/10/2014)... Calif., July 10, 2014   Ceres, Inc . ... seed company, announced today financial results for the three ... on its business. Ceres reported that the ... product performance this growing season in Brazil, which concluded ... the company,s sorghum evaluation areas for part of the ...
Breaking Biology Technology:Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9
... in Nature Physics , they used graphene, the world,s ... Graphene is a sheet of carbon atoms arranged in a ... signs of the conventional magnetism usually associated with such materials ... Manchester researchers the Nobel Prize in Physics in 2010. ...
... LONDON, January 6, 2012 The Lancet ... its first app for iPad is now available on the ... app that makes it easier for healthcare professionals (HCPs) to find ... their iPad. , ,"In this new mobile and tablet age, ...
... company developing a revolutionary non-invasive test for the early ... that it has achieved full automation of its Cell-CT™ ... biosignatures from intact cells.  Development of the fully automated ... $2.6 million grant from the National Institutes of Health,s ...
Cached Biology Technology:Graphene reveals its magnetic personality 2The Lancet Makes Research More Accessible for Healthcare Professionals With New App for iPad 2VisionGate Uses $2.6 Million NIH Grant to Achieve Full Automation of Cell-CT™ 3D Imaging System for Early Diagnosis of Cancer 2VisionGate Uses $2.6 Million NIH Grant to Achieve Full Automation of Cell-CT™ 3D Imaging System for Early Diagnosis of Cancer 3VisionGate Uses $2.6 Million NIH Grant to Achieve Full Automation of Cell-CT™ 3D Imaging System for Early Diagnosis of Cancer 4
...
... XL provides RS232/Serial data collection and automation ... Complete instrument integration with Microsoft Excel ... balances, pH meters, titrators, density meters, force ... and serial instruments can be added and ...
DNA sequencing - plasmids or PCR fragments, 3-7 working days service....
Nuclear/Cytosol Fractionation Kit Research Focus: other Storage Temperature: 4C Shipping Temperature: 4C...
Biology Products: