Navigation Links
Mixing genomics and geography yields insights into life and environment
Date:1/22/2009

In an upcoming issue of Proceedings of the National Academy of Sciences, Yale researchers used newly developed mathematical models to analyze huge amounts of data on physical characteristics such as temperature and salinity in different ocean habitats and metabolic activity in marine micro-organisms.

They were able to see in unprecedented detail how environment influences molecular changes within living organisms. As the technology dubbed "metagenomics" progresses, scientists might be able to detect environmental change or toxic chemicals not simply by using mechanical sensors or monitoring sensor species, but by examining biological changes within tiny organisms, said Mark Gerstein, the Albert L. Williams professor of biomedical informatics and professor of molecular biophysics & biochemistry and computer science.

"Such biosensors are the modern equivalent of canaries in a coal mine,' Gerstein said.

The research team was headed by computational biology and bioinformatics Ph.D. student Tara A. Gianoulis under the laboratories of Gerstein and Michael Snyder, the Lewis B. Cullman professor of molecular, cellular & developmental biology and professor of molecular biophysics & biochemistry, The team incorporated biochemical and environmental data from the previously published Global Ocean Survey, which catalogued information from 40 different aquatic sites. The GOS data effectively doubled the number of known proteins, and through a statistical analysis of these data, the Yale team was able to infer microbial adaptations to the environment.

"The genomics world has developed amazing technology that has captured a tremendous amount of information about living organisms, giving rise to an era of big data," Gerstein said. "Meanwhile, you have this explosion of geo-spatial information from satellites and global sensors. When key data sets connect these two disparate worlds, you find a subtle richness of connections."

Through a complex statistical analysis, the study showed that organisms switched energy conversion strategies depending on the environment, used components of membranes differently, and provided evidence that factors such as metals may play a large role in how micro-organisms adapt to their environments.


'/>"/>

Contact: Bill Hathaway
william.hathaway@yale.edu
203-432-1322
Yale University
Source:Eurekalert

Related biology news :

1. Mixing large doses of both acetaminophen painkiller and caffeine may increase risk of liver damage
2. Biogas production is all in the mixing
3. UCI and CODA Genomics collaborate to re-engineer yeast for biofuel production
4. Metagenomics of the deep Mediterranean
5. Metagenomics of the deep Mediterranean
6. NYUs Center for Genomics & Systems Biology receives $4.4 million NSF grant
7. Virginia Tech plant scientist leads study on genomics of parasitic plants
8. Launching a global alliance for pharmacogenomics
9. Beijing Genomics Institute adds AB SOLiD system to its next generation sequencing technologies
10. RevGenUK, a single-stop shop for use in functional genomics
11. Metagenomics of skin reveals insights into the human microbiome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/14/2016)... Nov. 14, 2016  xG Technology, Inc. ("xG" or ... critical wireless communications for use in challenging operating environments, ... 30, 2016. Management will hold a conference call to ... p.m. Eastern Time (details below). Key Recent ... $16 million binding agreement to acquire Vislink Communication Systems. ...
(Date:6/22/2016)... On Monday, the Department of Homeland Security (DHS) issued ... the Biometric Exit Program. The Request for Information (RFI), ... that CBP intends to add biometrics to confirm when ... , in order to deter visa overstays, to ... Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/9/2016)... control systems is proud to announce the introduction of fingerprint attendance control software, allowing ... are actually signing in, and to even control the opening of doors. ... ... ... Photo - http://photos.prnewswire.com/prnh/20160609/377487 ...
Breaking Biology News(10 mins):
(Date:11/30/2016)... ... November 30, 2016 , ... ... advanced technology applications, introduces the 5th generation, ultra-bright, Laser-Driven Light Source, the EQ-77, ... Light Source (LDLS™) technology, the EQ-77 offers higher radiance and irradiance from a ...
(Date:11/30/2016)... , ... November 30, 2016 , ... On 28 November ... symbols for four elements: nihonium (Nh), moscovium (Mc), tennessine (Ts), and oganesson (Og), ... public review, the names earlier proposed by the discoverers have been approved by the ...
(Date:11/30/2016)... ... November 30, 2016 , ... ... development of precision treatments for neurodegenerative diseases, today announced that all five of ... November 3, 2016) blocked propagation of toxic, prion-like forms of Amyloid beta (Aß) ...
(Date:11/30/2016)... November 30, 2016 Teil einer ... ... , Aptuit LLC ... zu haben. Zusätzliche 150.000 neuartige Substanzen haben die Prüfsammlung ... ausgewählt, um die starken Entdeckungsfähigkeiten des Unternehmens zu erweitern. ...
Breaking Biology Technology: