Navigation Links
Mitochondrial genome mutates when reprogrammed
Date:7/28/2011

This release is available in German.

Induced pluripotent stem cells (iPS cells) are truly talented multi-taskers. They can reproduce almost all cell types and thus offer great hope in the fight against diseases like Alzheimer's and Parkinson's. However, it would appear that their use is not entirely without risk: during the reprogramming of body cells into iPS cells, disease-causing mutations can creep into the genetic material. The genome of the mitochondria the cell's protein factories is particularly vulnerable to such changes. This phenomenon has been discovered by researchers at the Max Planck Institute for Molecular Genetics in Berlin. The scientists encountered mutations in the mitochondrial genome of iPS cells. Because such genetic mutations can cause diseases, the cells should be tested for such mutations before being used for clinical applications.

A lot of hope is riding on induced pluripotent stem cells (iPS cells). Because they can be generated individually for every single person, they are expected to enable the development of tailor-made therapies that do not run the risk of triggering rejection reactions. iPS cells also offer a promising solution for drug screening, as researchers can generate different cell types such as liver cells from them, on which they can then test the effect of substances. iPS cells can be generated from adult body cells using the technique of "cellular reprogramming". The method raises no ethical concerns as it does not involve the destruction of embryos.

However, these promising cells are also associated with certain risks. Disease-causing mutations can also arise during the reprogramming of the body cells. The genetic material in the mitochondria is particularly vulnerable to changes in the genetic code. The question as to whether such mutations arise as a result of the reprogramming process
'/>"/>

Contact: Dr. James Adjaye
adjaye@molgen.mpg.de
49-308-413-1203
Max-Planck-Gesellschaft
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. PGD can permit the birth of healthy children to women carrying mitochondrial DNA disease
2. Nitrate improves mitochondrial function
3. Cell death pathway linked to mitochondrial fusion
4. Extracting cellular engines may aid in understanding mitochondrial diseases
5. Children with autism more likely to have mitochondrial defects impacting cellular energy production
6. How mitochondrial gene defects impair respiration, other major life functions
7. BGI develops new strategy to uncover structural variations of human genomes
8. BGI and National Wolfberry Engineering Research Center launch Chinese wolfberry genome project
9. The first studies utilizing the Collaborative Cross mice are published in Genome Research
10. BGI contributes whole genome sequencing and bioinformatics expertise to potato genome research
11. Simple little spud helps scientists crack potatos mighty genome
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mitochondrial genome mutates when reprogrammed
(Date:1/22/2015)... NXTD and NXTDW) a biometric authentication company focused on ... Wocket™ smart wallet at CES 2015 in Las Vegas ... the "11 Hot Products at CES" in a review published in Wired.com, ... Newseveryday.com and "The top 10 gadgets from CES 2015" by Danny ...
(Date:1/22/2015)... Jan. 21, 2015  Analyst Report Issued by Small Cap IR. ... showed that planet-wide, transactions at merchants on the leading payment ... number of credit, debit, and prepaid cards reached 6.54 billion.  ... of fraudulent card usage in 2012, and credit and debit ...
(Date:1/22/2015)... Research and Markets ( http://www.researchandmarkets.com/research/wxdglm/global_wearable ) ... Wearable Technologies Market and Applications, Opportunities, Industry Analysis, ... 2014-2020" report to their offering. , ... can be worn on the user,s body and ...
Breaking Biology News(10 mins):CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2
... TORONTO, March 2, 2010 The levels of contamination to ... exceed provincial water quality standards, in some cases by as ... by researchers at the University of Toronto Scarborough. This is ... winter, especially to Highway 401, the study finds. Roads, ...
... the open sand plains of the Caribbean seafloor, where soft-bodied ... to survival. Perhaps no group of animals is quite as ... along with relatives the cuttlefish and squid, have evolved a ... In the February 2010 issue of The Biological ...
... American Society for Microbiology (ASM) GlaxoSmithKline International ASM ... Hans Wolf-Watz, Ph.D., Professor, Ume University, Sweden, for ... host-pathogen interaction of Yersinia, as well as his ... in the field. This award recognizes a distinguished ...
Cached Biology News:Road salt and cars produce extreme water contamination in Frenchman's Bay, UTSC research reveals 2Road salt and cars produce extreme water contamination in Frenchman's Bay, UTSC research reveals 3A convincing mimic: Scientists report octopus imitating flounder in the Atlantic 2
(Date:1/22/2015)... Davis, California (PRWEB) January 22, 2015 ... of Accelerator Mass Spectrometry (AMS) services to the pharmaceutical ... PhD has joined the company in the position of ... 30 years of broad and valuable experience in drug ...
(Date:1/22/2015)... , Jan. 22, 2015  Transwestern | RBJ today announces ... of office space for Shire a leading biopharmaceutical company, at ... Transwestern | RBJ,s Robert Richards , president, and ... lease for the entire five-floor building at 95 Hayden Ave. ...
(Date:1/22/2015)... 2015 Crystal Diagnostics (CDx) Xpress System, a ... received AOAC-PTM Certifications for the six non-O157 Shiga toxin-producing E. ... referred to as STEC or the “Big-6”) as well as ... (cfu) per 325 g of raw ground beef and raw ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Controlled Substance ... Alliance, which helps companies check the legal requirements around ... expand to China. , As their international operations ... globally adopting software solutions built as a result of ...
Breaking Biology Technology:Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 2Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 3Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Global Compliance Service for Controlled Substances to Expand to China 2
... a global chemistry-driven contract research organization, announced today that ... one of the leading CRO companies conducting high quality ... Prudentas will continue to operate separately under the business ... to the acquisition ChemDiv had worked with Prudentas, who ...
... Science, Scale and Talent Required to Meet Growing Demand , ... ... enable farmers to produce enough grain to meet the growing demand ... regulators and policymakers from around the globe take a more holistic ...
... Accreditation StandardsWASHINGTON, April 16 URAC ... announced today that Director of Pharmacy Programs Janice Anderson, ... 21st Annual Academy of Managed Care Pharmacy (AMCP) ... health care professionals dedicated solely to the issues of ...
Cached Biology Technology:ChemDiv Group Acquires Prudentas Through ChemRar High Tech Center 2ChemDiv Group Acquires Prudentas Through ChemRar High Tech Center 3DuPont Leader: Agriculture is Up to Global Productivity Challenge 2DuPont Leader: Agriculture is Up to Global Productivity Challenge 3DuPont Leader: Agriculture is Up to Global Productivity Challenge 4URAC Director of Pharmacy Programs to Speak at Academy of Managed Care Pharmacy Annual Meeting 2URAC Director of Pharmacy Programs to Speak at Academy of Managed Care Pharmacy Annual Meeting 3
Human acetylcholine receptor (AChR)-alpha. Exhibits homogenous, high affinity,binding to the receptor. Binds weakly to a64-78. Inhibits binding of many,myasthenia gravis sera to human AChR....
...
Hybridization Buffer 3.6 ml...
Mouse monoclonal [0.N.305] to G protein alpha - BSA and Azide free ( Abpromise for all tested applications). Antigen: Partially purified G protein alpha from rat brain. Entrez GeneID: 2778 ...
Biology Products: