Navigation Links
Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer
Date:7/14/2008

This release is available in Spanish.

Cancer is a disease characterised by important metabolic alterations. Not only these adaptative changes give higher proliferative capacity to cancer cells, but they also contribute to higher resistance to chemotherapeutic agents. The research group led by Dr. Jos Carlos Fernndez-Checa in the Institut d'Investigacions Biomdiques de Barcelona of the CSIC (IIBB-CSIC), a centre linked to the Institut d'Investigacions Biomdiques August Pi i Sunyer (IDIBAPS), is centred in the mitochondrion and its role in programmed cell death or apoptosis. The mitochondrion is the organelle in charge of the cell's respiration and of energy generation to satisfy important metabolic functions, which are altered in cancer. In an article published in Cancer Research (68(13):5246-56) with Joan Montero and Albert Morales as first signatories and Ana Colell as co-director of the study, IIBB-CSIC-IDIBAPS researchers describe how the increase of cholesterol in the mitochondrial membrane plays a key role in the resistance to cytotoxic agents acting via mitochondrion, including doxorubicin, a common drug in chemotherapy. This research has been developed in the framework of the Centre of Network Biomedical Research on Hepatic and Digestive diseases (CIBERehd).

Hepatocarcinoma is the most frequent form of hepatic cancer. It has a high mortality rate due to, among other causes, the lack of an effective treatment and due to its high resistance against the current chemotherapy strategy. In order to improve the quality of treatments, it is important to identify the strategies permitting the cell to avoid chemotherapy's toxicity. The supraphysiological level of mitochondrial cholesterol in hepatocarcinoma and in other cancers is well known, but its role in the mitochondrial regulation of cellular death and resistance to chemotherapy was not known.
'/>"/>

Contact: lex Argem
aargemi@clinic.ub.es
34-932-275-700
IDIBAPS - Institut d'Investigacions Biomdiques August Pi i Sunyer
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Zebrafish to shed light on human mitochondrial diseases
3. Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia
4. Hebrew University develops novel approach for treating mitochondrial disorders
5. Dominant cholesterol-metabolism ideas challenged by new research
6. Research explains link between cholesterol and heart disease
7. Cholesterol metabolism links early- and late-onset Alzheimers disease
8. Corazonas Foods and Brandeis University partner to create cholesterol-reducing snacks
9. MIT links gene to cholesterol
10. More on mate tea: lower cholesterol and an international agreement
11. Contribution of cholesterol transporter to vascular disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... 30, 2014) People who suffer from asthma may ... control their asthma besides properly taking medications and avoiding ... in the Annals of Allergy, Asthma and Immunology ... Allergy, Asthma and Immunology (ACAAI), asthma sufferers can learn ... The woman described in the Annals article improved her ...
(Date:9/29/2014)... Monday, September 29: Between 1970 and 2010 populations ... the globe dropped 52 percent, says the 2014 ... Fund (WWF). This biodiversity loss occurs disproportionately in ... of high-income countries. , In addition to the ... point to other warning signs about the overall ...
(Date:9/29/2014)... In order to support the world,s needs ... polymers and more, new and more efficient catalytic ... of researchers, including several from Wayne State University, ... a new grant from the National Science Foundation. ... Design of Multicomponent Materials for Electrocatalytic Cascade Reactions," ...
Breaking Biology News(10 mins):Asthma symptoms kicking up? Check your exposure to air pollution 2Half of global wildlife lost, says new WWF report 2Wayne State research aims to develop new, more efficient catalytic materials 2
... boost our understanding of the fragile marine environment, the ... for Environment, Fisheries & Aquaculture Science (Cefas) are launching ... existing collaboration between the two institutions and establish exciting ... climate change on the marine environment will influence much ...
... science concern the behaviour of the most commonplace compound ... the mysteries are now being unravelled by the latest ... was presented at a recent conference organised by the ... and other compounds at the molecular level. , Some ...
... window into the Earths mantle, a University of Houston professor ... more complex than previously thought. Jonathan Snow, ... researchers in a North Pole expedition, resulting in a discovery ... layer that lies beneath the planets outer crust. These ...
Cached Biology News:New UEA-Cefas alliance launched 2ESF conference probes water's mysterious interactions at molecular level 2ESF conference probes water's mysterious interactions at molecular level 3Journey to the center of the earth: Discovery sheds light on mantle formation 2Journey to the center of the earth: Discovery sheds light on mantle formation 3
(Date:9/30/2014)... September 30, 2014 Lyme Research ... of Lyme disease research at universities, today announced the ... on the identification, treatment and cure for Lyme and ... received the most applications in its history—over 20 grant ... “While we were pleased to receive so many solid ...
(Date:9/30/2014)... 30, 2014 Rainbow Scientific, Inc. ... products, recently opened an online store to add ... product lines developed and manufactured by Biological Industries, ... include Biological Industries’ Nutristem® serum-free, xeno-free reagents for ... stem cell (hESC) culture. , The online ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 UFP ... and specialty packaging has recently introduced a custom ... Suspension Pack . The new insulated shipper solves ... chain distribution process. UFP Technologies’ BioShell is a ... bags during storage, handling and shipping. The insulated ...
(Date:9/30/2014)... Ontario, Canada (PRWEB) September 30, 2014 Back ... based on 500 square feet. per employee, which included space ... world back then.” says Jeff Howell, partner at Nidea ... advisory firm in Toronto. “By the year 2000, however, ... are now seeing that number come down to 175 to ...
Breaking Biology Technology:Lyme Research Alliance Awards Nearly $600,000 in New Grants 2Lyme Research Alliance Awards Nearly $600,000 in New Grants 3Lyme Research Alliance Awards Nearly $600,000 in New Grants 4Rainbow Scientific, Inc. opens online store for state-of-the-art stem cell culture and cytogenetic reagents 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 3ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 3
... RedPrairie Corp. , the Waukesha-based manufacturer of supply chain ... a recent user conference. , ,At RedShift: 2006, the ... unveiled its E2e suite of solutions, which is described ... chain challenges faced by customers. , ,RedPrairie executive John ...
... - By several measures, these should be heady days ... manufacturing jobs were lost, the economy is back, manufacturing revenue ... there is a sense of unease linked to withering competitive ... of what their American counterparts earn, where manufacturers have a ...
... that the ownership of a patent right initially goes to ... in the workplace? The company? The inventing employee? It depends ... Is there an employment agreement signed by the employee that ... workplace to the company? , ,No? Then you must ask: ...
Cached Biology Technology:Manufacturers advised to redesign customer relations 2Manufacturers advised to redesign customer relations 3Who owns what invention in the workplace? 2
... Acid Resistant SpeedVac Model SPD131DDA , ... The SPD131DDA is designed to handle the rigors ... new slim design, digital display, dual independent timers, ... coated chamber and vapor pathway. , , ...
... The University of New South Wales, Sydney, Australia ... Australia This is the Fourth Edition of this ... is a large format version (330 x ... 3rd edition. This product number includes the ...
... RC10 series of vacuum concentrators/centrifugal evaporators offers ... allied to rapid and safe concentration of ... combined with oil-free or high vacuum pumps, ... wide selection of rotors (eliminating sample loss ...
... Thermo Electron's most advanced personal gradient option ... use sophisticated onboard software and a large ... offer performance, accuracy and simplicity in thermal ... customer driven features built up on years ...
Biology Products: