Navigation Links
Missing sugar molecule raises diabetes risk in humans
Date:2/24/2011

f all animal cells, where they act as vital contact points for interaction with other cells and with their surrounding environment. Virtually all mammals produce two types: N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc).

Humans are the exception. For reasons lost in the mists of evolution, a mutation in a gene called CMAH occurred 2 to 3 million years ago, inactivating an enzyme in humans that catalyzes production of Neu5Gc by adding a single oxygen atom to Neu5Ac.

Researchers compared two groups of mice: one with a functional CMAH gene, the other with an altered CMAH gene similar to the human mutation. Both groups of mice were fed a high-fat diet. Mice in both groups became obese and developed insulin resistance. However, only mice with the CMAH gene mutation experienced pancreatic beta cell failure the cells that make and release insulin, a hormone that controls blood sugar levels.

Kim said the findings help refine understanding of why obese humans appear to be particularly vulnerable to type 2 diabetes, and also suggest that current animal models used to study diabetes may not accurately mirror the human condition. In clinical terms, she said further research to determine how sialic acid composition affects pancreatic beta cell function may reveal new strategies to preserve the cells, improve insulin production and prevent diabetes.


'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related biology news :

1. Fish provide missing piece in the marine sediment jigsaw
2. New evolutionary research disproves living missing link theories
3. Missing molecules hold promise of therapy for pancreatic cancer
4. Phosphorus identified as the missing link in evolution of animals
5. Link to autism in boys found in missing DNA
6. Missing Puma reveals cancer conundrum
7. Study shows adding UV light helps form Missing G of RNA building blocks
8. New methods identify thousands of new DNA sequences missing from the human genome reference map
9. High-performance computing reveals missing genes
10. Cells can read damaged DNA without missing a beat
11. Plants on steroids: Key missing link discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... study of American singles found that during sex ... orgasm rates. On average, men experience orgasm 85.1 ... making little difference. For women, however, orgasm occurrence ... 62.9 percent of the time during sex with ... with women,s sexual orientation, with lesbian women experiencing ...
(Date:8/21/2014)... darkness use a previously unknown process for harvesting energy ... by a Penn State University scientist has discovered. The ... improving plant growth, harvesting energy from the Sun, and ... Erie and other lakes worldwide. A paper describing the ... Express edition of the journal Science on ...
(Date:8/21/2014)... skin fungus linked to dandruff, eczema and other itchy, ... even further global reachesincluding Hawaiian coral reefs and the ... , A review in the scientific journal PLOS ... the fungi of the genus Malassezia in ... datasets from around the world. , University of Hawai,i ...
Breaking Biology News(10 mins):Orgasm rates for single women less predictable than men's, vary by sexual orientation 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 3Orgasm rates for single women less predictable than men's, vary by sexual orientation 4Hot-spring bacteria reveal ability to use far-red light for photosynthesis 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 3From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2
... January 25, 2011 23andMe,s sarcoma research efforts are ... data from 500 individuals diagnosed with sarcoma already completed. ... of building a sarcoma research community of more than ... Scientific Advisory Committee with the appointment of leading researchers ...
... researchers have reproduced portions of the female breast in ... be used to test nanomedical approaches for the detection ... the branching mammary duct system, where most breast cancers ... study the use of nanoparticles to detect and target ...
... can establish a social infrastructure that facilitates successful science-based ... peer networks, according to a study from the U.S. ... of the studywhich is featured in the January issue ... the stationcan help watershed councils increase the effectiveness of ...
Cached Biology News:23andMe sarcoma research community reaches 500 and announces Sarcoma Scientific Advisory Committee 2Purdue team creates 'engineered organ' model for breast cancer research 2Purdue team creates 'engineered organ' model for breast cancer research 3Purdue team creates 'engineered organ' model for breast cancer research 4Immersive data collection, peer networks among key elements of effective watershed councils 2
(Date:8/21/2014)... MOUNTAIN VIEW, Calif. , Aug. 21, 2014 ... their properties and behaviors based on external stimuli ... is poised to have a disruptive effect in ... will revolutionize the business landscape by printing objects ... the aerospace and automotive sectors. Logo ...
(Date:8/21/2014)... 21, 2014 Gallus BioPharmaceuticals ... development and manufacturing organization (CMO) announced today that ... an oncology company focused on the development of ... manufacture the anti-prostate specific membrane antigen (PSMA) monoclonal ... Under the agreement the antibody will be ...
(Date:8/20/2014)... Aug. 20, 2014 Clintrax Global, Inc., ... in Raleigh, NC , recently ... as Vice President of Administration. ... all corporate processes, including their alignment with company ... Brad worked as an HR executive, specializing in ...
(Date:8/20/2014)... measuring vibrational motion of a single molecule with a ... a single molecule differs from the behaviour of larger ... the University of California, Irvine, where post-doctoral researcher Eero ... visiting fellow under professor Vartkess A. Apkarian, whose team ... by Professor Eric O. Potma. The results of the ...
Breaking Biology Technology:Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3Clintrax Global, Inc. Announces Addition to Executive Team 2Seeing a molecule breathe 2
... , BIRMINGHAM, Ala., July 29 ... Sandy, Utah, has been appointed as Chief Medical Officer of ... a primary care physician, board-certified lipidologist and certified hypertension specialist. ... the public and health care professionals about Atherotech,s line of ...
... , , MANCHESTER, England, July 29 ... http://www.stemcellaware.com ) seventh awareness rally, past ... to learn about stem cell technologies and discuss the various ... Stem cell advocate Darren Clarke is organizing the Manchester ...
... ... Change at Change ... on a constant, Q2 ... basis rates H1 2009 basis rates, ------- ...
Cached Biology Technology:Atherotech Taps Canyons Medical Center Director, Lipidologist as Chief Medical Officer 2Atherotech Taps Canyons Medical Center Director, Lipidologist as Chief Medical Officer 3First U.K. Stem Cell Awareness Rally to Take Place in Manchester, England on August 9th, 2009 2First U.K. Stem Cell Awareness Rally to Take Place in Manchester, England on August 9th, 2009 3Sanofi-aventis Announces Second Quarter 2009 Results 2Sanofi-aventis Announces Second Quarter 2009 Results 3Sanofi-aventis Announces Second Quarter 2009 Results 4Sanofi-aventis Announces Second Quarter 2009 Results 5Sanofi-aventis Announces Second Quarter 2009 Results 6Sanofi-aventis Announces Second Quarter 2009 Results 7Sanofi-aventis Announces Second Quarter 2009 Results 8Sanofi-aventis Announces Second Quarter 2009 Results 9Sanofi-aventis Announces Second Quarter 2009 Results 10Sanofi-aventis Announces Second Quarter 2009 Results 11Sanofi-aventis Announces Second Quarter 2009 Results 12Sanofi-aventis Announces Second Quarter 2009 Results 13Sanofi-aventis Announces Second Quarter 2009 Results 14Sanofi-aventis Announces Second Quarter 2009 Results 15Sanofi-aventis Announces Second Quarter 2009 Results 16Sanofi-aventis Announces Second Quarter 2009 Results 17Sanofi-aventis Announces Second Quarter 2009 Results 18Sanofi-aventis Announces Second Quarter 2009 Results 19Sanofi-aventis Announces Second Quarter 2009 Results 20Sanofi-aventis Announces Second Quarter 2009 Results 21Sanofi-aventis Announces Second Quarter 2009 Results 22Sanofi-aventis Announces Second Quarter 2009 Results 23Sanofi-aventis Announces Second Quarter 2009 Results 24Sanofi-aventis Announces Second Quarter 2009 Results 25Sanofi-aventis Announces Second Quarter 2009 Results 26Sanofi-aventis Announces Second Quarter 2009 Results 27
LabFax: Immunochemistry...
Recombinant Ovine (Sheep) Growth Hormone, Ultra Pure...
albumin from bovine serum (BSA), 2,4-dinitrophenylated (DNP-BSA)...
... contains 5 ml Dynabeads® ... monoclonal BerEP4 against the human ... adhesion molecule). Also available in ... x 10e7 MNC in 1 ...
Biology Products: