Navigation Links
Missing molecules hold promise of therapy for pancreatic cancer
Date:12/15/2010

sue from mice and zebrafish to see what happened when KRAS was activated.

Every time, the team noted the same robust findings. When KRAS was activated, the microRNA cluster miR-143/145 was powerfully repressed, to a fraction of the levels in normal, non-cancerous cells. Restoring the expression of miR-143/145 back to the level of normal cells was sufficient to confer "a very striking change in behavior of those cells," Mendell says. When human pancreatic cancer cells with low microRNA levels were injected into mice, they formed tumors within 30 days. However, when the team restored the levels of microRNAs to the levels of normal cells and injected them into mice, tumors failed to form.

"Our findings showed that repression of the miR-143/145 microRNA cluster is a very important component of the tumor-promoting cellular program that is activated when KRAS is mutated in cancer cells," says Oliver Kent, a postdoctoral fellow in the Mendell laboratory and first author on the paper.

At some point in the process of a normal cell evolving into a tumor cell, it loses microRNAs. When the KRAS gene is mutated a common event in pancreatic cancer it somehow purges cells of miR-143/145, the cluster of microRNAs that normally put the brakes on tumorigenesis.

"It is likely that some microRNAs will have very broad antitumorigenic effects in many different types of cancers," says Mendell, whose lab is building animal models to investigate how different microRNAs participate in different tumor types. "In fact, there is already evidence that miR-143/145 can suppress other types of tumors such as colon and prostate cancer. On the other hand, the effects of some microRNAs will likely be very tumor-specific."

Merely 22 nucleotides in length, microRNAs are enigmatic bits of genetic material that, despite being pint-sized, apparently are mighty. This field of study is less than a decade old; scientists still don't have a good gras
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Missing: 2,000 elephants
2. Missing genes link to psoriasis
3. Missing piece of plant clock found
4. A missing enzyme conveys major heart protection in pre-clinical work
5. Fossil evidence of missing link in the origin of seals, sea lions, walruses found in Canadian Arctic
6. Yeast missing sex genes undergo unexpected sexual reproduction
7. New therapy substitutes missing protein in those with muscular dystrophy
8. Researchers restore missing protein in rare genetic brain disorder
9. Plants on steroids: Key missing link discovered
10. Cells can read damaged DNA without missing a beat
11. High-performance computing reveals missing genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... -- According to a new market research ... Emotion, Forensic), by Software (Middleware, Databases), by Hardware (Cameras, Integrated ... Home) - Global Forecast to 2020", published by MarketsandMarkets, ... 2015 to $6.19 Billion by 2020, at a CAGR ... Tables and   43 Figures spread through 140 Pages ...
(Date:5/19/2015)... Fingerprint Cards (FPC) has received an ... and FPC1035 from one if its module partners. Deliveries are ... 2015 and the sensors will be used by smartphone manufacturers ... 2015 hereby amount to 740 MSEK to date. In addition ... and a number of smaller orders not separately communicated amounting ...
(Date:5/14/2015)... 2015  Verificient Technologies, Inc., a technology ... remote proctoring, announced a new alliance partnership ... creator of the Canvas Learning Management System ... will benefit from the seamless integration of ... a fully integrated multifactor biometrics behavioral application, ...
Breaking Biology News(10 mins):Facial Recognition Market Worth $6.19 Billion by 2020 2Facial Recognition Market Worth $6.19 Billion by 2020 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2
... United States are releasing enough carbon into the atmosphere to ... Yale researchers in Nature Geoscience . Their findings could ... land, water and the atmosphere. "These rivers breathe a ... co-author of a study with Pete Raymond, professor of ecosystem ...
... memories than those who don,t have this gene variant. This means ... compensates for this. This is shown by researchers from Ume University ... study, KIBRA was first examined in relation to the memory performance ... carriers of the KIBRA T allele performed better than non-carriers. Then ...
... 2011 The Peggy Lillis Memorial Foundation will present ... President of Optimer Pharmaceuticals, Inc. and Distinguished Professor (Emeritus) ... an achievement award to recognize his nearly four decades ... Clostridium difficile infection (CDI) a bacterial ...
Cached Biology News:US rivers and streams saturated with carbon 2Gene variant leads to better memory via increased brain activation 2Peggy Lillis Foundation honors Dr. Sherwood Gorbach for career combating C. diff infection 2Peggy Lillis Foundation honors Dr. Sherwood Gorbach for career combating C. diff infection 3
(Date:5/29/2015)... 2015 GeneWEAVE, Inc ., ... announced that initial feasibility data supporting the use ... susceptibility testing from positive blood cultures will be ... 2015 in New Orleans, LA. The Company’s Smarticles™ ... that can quickly detect bacteria and assess antibiotic ...
(Date:5/29/2015)... The Academy of Model Aeronautics has ... graduates from across the nation. , The Academy of ... AMA Youth Members with scholarships to pursue technical careers. ... has awarded nearly $900,000 to college-bound aero-modelers. The scholarships ... and individuals, AMA member donations, a portion of AMA ...
(Date:5/29/2015)... Asthma treatment could   ...   treatments enter arena, says   GBI Research ... facing several of the leading asthma brands, such as ... (omalizumab), the global market for asthma treatment is set ... decade.   New analysis from business intelligence ...
(Date:5/29/2015)... Market Publishers Ltd and Shanghai ... partnership agreement for quality market research promotion on ... sell research reports worked out by Chem-Report. , ... upon the agreement: “Chem-Report is a Chinese company ... chemical markets on global and country levels. The ...
Breaking Biology Technology:Data Highlighting GeneWEAVE’s Smarticles™ Technology to be Presented at the 115th General Meeting of the American Society for Microbiology (asm2015) 2Data Highlighting GeneWEAVE’s Smarticles™ Technology to be Presented at the 115th General Meeting of the American Society for Microbiology (asm2015) 3Academy of Model Aeronautics Awards $46,500 in Scholarships to College-Bound Model Aviation Pilots 2Personalized Treatment for Severe Asthma to Drive Market Growth Despite Patent Expirations 2Personalized Treatment for Severe Asthma to Drive Market Growth Despite Patent Expirations 3Market Publishers Ltd and Chem-Report Sign Partnership Agreement 2Market Publishers Ltd and Chem-Report Sign Partnership Agreement 3
... Inc., a drug discovery and development company, is pleased,to ... Early Stage,Company of the Year Award by BIOTECanada in ... to have received this prestigious award, one of,BIOTECanada,s four ... President and CEO. "This honor is important and made ...
... UTRECHT and ZAANDAM, The Netherlands, June 17 , ... Today the payment processor Equens and supermarket chain ... with your fingertip. For a period of,six months, customers ... their,shopping using their fingertips. The objective of the pilot ...
... group led by Yasushi Okamura, a professor in Japanese ... a professor in Oregon Health & Science University, Oregon, ... Sensor Only Protein/ Hv1, can carry protons even without ... be expressed in phagocytes such as macrophage and neutrophil ...
Cached Biology Technology:Start of First Fingertip Payment Pilot in the Netherlands 2Start of First Fingertip Payment Pilot in the Netherlands 3
Tight junctions are complexes of proteins that create intercellular boundaries between the plasma membrane domains of epithelial and endothelial cells. Antigen: Synthetic peptide corresponding to...
Biotin anti-mouse CD48...
PMA (YPMA-1)...
Request Info...
Biology Products: