Navigation Links
'Missing link' discovered in the defence mechanism of the tuberculosis pathogen
Date:11/14/2012

Brussels, 14 November 2012 Flemish biologists lead by Joris Messens (VIB / Vrije Universiteit Brussel) have discovered that Mycobacterium tuberculosis the bacterium that causes tuberculosis has an ingenious defence mechanism against oxygen. This knowledge is important in the search for a treatment for tuberculosis. 9.4 million people are infected with tuberculosis annually and 1.7 million people die as a result.

Joris Messens: "We have discovered how Mycobacterium survives the oxygen stress in our body, namely with the aid of the protein mycoredoxin-1. This opens up a whole new field of research into the role of this protein during a tuberculosis infection. A better understanding of this mechanism will enable us to combat this bacterium more selectively".

Oxygen, a necessary evil

Oxygen is essential for the respiration of nearly all cells. They use this gas to burn sugars in order to produce energy. However, oxygen is also very aggressive and can seriously affect proteins the building blocks of the cell in a manner similar to rust or oxidation of iron.

Attacking essential proteins

Our immune system uses reactive oxygen molecules in the defence against intruders, for example against Mycobacterium. Proteins are particularly sensitive to the effects of oxygen (oxidation). Proteins with sulphur-containing components are particularly sensitive and become inactive with oxidation. Following damage by oxygen, Mycobacterium places the mycothiol molecule on such proteins. After a period of oxygen stress this molecule has to be removed again for the proper functioning of the protein. It was not known how this happened, until now.

Protection and recovery

Joris Messens and his team have discovered that Mycobacterium tuberculosis protects sulphur-containing proteins in a unique way and actively repairs these proteins once the oxygen stress disappears. They discover
'/>"/>

Contact: Joris Messens
info@vib.be
32-478-911-288
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related biology news :

1. UCLA researchers discover missing link between stem cells and immune system
2. What we know and dont know about Earths missing biodiversity
3. Researchers discover first gene linked to missing spleen in newborns
4. Uranium exposure linked to increased lupus rate
5. Gene variations linked to lung cancer susceptibility in Asian women
6. USF researchers identify gene mutation linked to old age hearing loss
7. New study confirms erroneous link between XMRV and prostate cancer-contamination was the cause
8. Sinusitis linked to microbial diversity
9. Newly discovered letters and translated German ode expand Texas link to infamous Bone Wars
10. 10 new diabetes gene links offer picture of biology underlying disease
11. BUSM/VA Boston Healthcare System investigators identify new gene linked to PTSD
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/8/2015)... , April 8, 2015  Infinisource, a leading ... services, and Morpho, a leading supplier of biometric ... produce the market,s most advanced biometrically-enabled time clock, ... NXG time clock is setting a bold, new ... data for the small and mid-size employer. When ...
(Date:4/2/2015)... HAMBURG, Germany , April 2, 2015 /PRNewswire/ ... ten fingerprint tests DERMALOG by far outperforms the ... While always maintaining high accuracy, the system is ... second. Hence, the speed proves up to be ... 40% faster than its runner-up performance. ...
(Date:4/2/2015)... GOTHENBURG, Sweden , April 2, 2015 ... revenues for Q1 2015 attributed to somewhat higher than ... company in the year-end report 2014 that revenues for ... MSEK that the company reported for Q4 2014. The ... continue to be negative. The complete interim report will ...
Breaking Biology News(10 mins):iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Fingerprint Cards Revises Revenues for Q1 2015 2
... of Pennsylvania School of Medicine & School of Engineering ... deliver drugs to tumors. By using a cylindrical-shaped carrier ... paclitaxel to an animal model of lung cancer ten ... findings have implications for drug delivery as well as ...
... vitamin was named, what is known about them ... public health, says Irwin Rosenberg, MD, University Professor, ... at the Jean Mayer USDA Human Nutrition Research ... on his presentation at the National Institutes of ...
... was published in an advance online edition of the Proceedings ... April 9, 2007. , The study provides new evidence that ... is activated by the protein SGT1, which also activates Resistance ... pathogens. The study also confirms structural similarities between the Nod1 ...
Cached Biology News:Penn researchers show how nanocylinders deliver medicine better than nanospheres 2Vitamins: Science doesn't always match policy 2Scripps research study shows humans and plants share common regulatory pathway 2Scripps research study shows humans and plants share common regulatory pathway 3
(Date:4/27/2015)... Ohio (PRWEB) April 27, 2015 ... of an agreement with Joslin Diabetes Center (“Joslin”) ... 2b study of Diasome’s novel Hepatocyte Directed Vesicle ... Type 1 diabetes. , Located in Boston, ... clinical care and education organization dedicated to the ...
(Date:4/24/2015)... and Tempe, AZ (PRWEB) April 24, 2015 ... and Arizona State University (ASU) have entered into an ... projects. , A memorandum of agreement signed by the ... distance learning, student success and other services particularly, though ... , “We have complementary strengths and a similar ...
(Date:4/24/2015)... MONTREAL , April 24, 2015 /CNW Telbec/ - Mirego, ... part of the making of three mobile app extensions for ... for its clients, Familiprix, OMSignal and MediaMiser, these ... information thanks to functions designed specifically for wrist use.  ... the Apple Watch is a highly customizable tactile smartwatch that ...
(Date:4/23/2015)... CA (PRWEB) April 23, 2015 Athena ... personal development of executive women in San Diego’s technology ... the 17th Annual Pinnacle Awards at their Gala on ... Hyatt Hotel. Register now at http://athenasd.org/events/ , ... support the Athena San Diego vision of fostering networking, ...
Breaking Biology Technology:Diasome Pharmaceuticals Announces Clinical Trial Design Collaboration 2South Dakota Mines, Arizona State University Pave Way for Cooperative Research 2Familiprix, OMSignal and MediaMiser apps available today for Apple Watch 2Athena Pinnacle Awards to Honor Executives, Corporations and Educators Working to Promote Women Leaders 2
... 5 Dynamic Alert,Limited (OTC Bulletin Board: DYMC) ... its target markets for its pharmaceutical product line-up. ... for enhancing rapid onset,through oromucosal absorption, topical applications, ... internal use. Some products will have,specific uses, while ...
... Dec. 5 Early clinical experience with the FDA,cleared ... of ultrasound guided cryoablation to completely eradicate,small, unifocal Invasive ... study was presented at the 94th Scientific Assembly and ... November 29 -,December 5, 2008. , ...
... Senesco Technologies, Inc. ("Senesco" or the "Company") (NYSE Alternext ... Agreement with the http://www.senesco.com ("Harris Moran") has ... recently announced corporate restructuring. , ... parent company, Limagrain, restructured its vegetable seed operations and ...
Cached Biology Technology:Dynamic Outlines Initial Target Markets for Pharmaceutical Cannabinoid Products 2Dynamic Outlines Initial Target Markets for Pharmaceutical Cannabinoid Products 3Cryoablation of Early Invasive Ductal Breast Cancer With MRI Confirmation Shows Promising Clinical Benefits, According to Study Presented at RSNA 2Cryoablation of Early Invasive Ductal Breast Cancer With MRI Confirmation Shows Promising Clinical Benefits, According to Study Presented at RSNA 3Senesco and Harris Moran Mutually Agree to Terminate Development and License Agreement Due to Restructuring 2Senesco and Harris Moran Mutually Agree to Terminate Development and License Agreement Due to Restructuring 3
... service is for when you need to make ... their transformation efficiency. Our services for preparing competent ... applications. MCLab's custom competent cell service offers: ... Fast turnaround Quality control ...
... WR Cryoscope for molecular weight determinations for petroleum-based applications. Multiple solvents can be used, such ... ... ... ...
Growth Medium / Media...
... Sensitivity Laboratory Osmometer for 50 L samples. Operating head automatically rises at the end of determination; triple-point ... ... ... ...
Biology Products: