Navigation Links
Missing Puma reveals cancer conundrum
Date:7/31/2010

Walter and Eliza Hall Institute researchers in Melbourne, Australia, have made a discovery that has upended scientists' understanding of programmed cell death and its role in tumour formation.

Programmed cell death, also called apoptosis, is an important process in human biology as it removes unwanted and damaged cells from our bodies. This process protects us against cancer development and autoimmune disease.

The research team's discovery, led by Professor Andreas Strasser from the institute's Molecular Genetics of Cancer Division, has implications for the understanding of how cancers develop and will inform the ongoing development of a new class of anti-cancer drugs called BH3 mimetics.

"Until now everybody believed that a failure of damaged cells to undergo suicide allowed mutated cells to proliferate, which contributes to tumour development," Professor Strasser said. "That's certainly still true but we discovered that, in certain settings, the opposite holds: the body's natural cell-suicide program can fuel tumour development."

The research team's experiments revealed that repeated cycles of cellular depletion and tissue regeneration, by activating stem cells, could promote tumour development.

In situations where the DNA in many cells is damaged, such as when the body is repeatedly exposed to low doses of radiation, there are repeated cycles of cell death in the body's tissues. "Attempts by the body's stem cells to repopulate the depleted tissue can then actually drive the tumour development," Professor Strasser said. "That's because the radiation, while killing many cells within a tissue, will create mutations in some of the surviving stem cells. When such abnormal (mutated) stem cells repopulate the tissue, they will divide many times and this can promote the development of tumours."

The research, done in collaboration with Dr Ewa Michalak, Dr Cassandra Vandenberg, Mr Alex Delbridge, Dr Li Wu, Dr C
'/>"/>

Contact: Penny Fannin
fannin@wehi.edu.au
61-393-452-345
Walter and Eliza Hall Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Missing: 2,000 elephants
2. Missing genes link to psoriasis
3. Missing piece of plant clock found
4. A missing enzyme conveys major heart protection in pre-clinical work
5. Fossil evidence of missing link in the origin of seals, sea lions, walruses found in Canadian Arctic
6. Yeast missing sex genes undergo unexpected sexual reproduction
7. New therapy substitutes missing protein in those with muscular dystrophy
8. Researchers restore missing protein in rare genetic brain disorder
9. Plants on steroids: Key missing link discovered
10. Cells can read damaged DNA without missing a beat
11. High-performance computing reveals missing genes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Missing Puma reveals cancer conundrum
(Date:9/18/2014)... a world-leading provider of scientific, technical and medical ... Management Society (ARMS), recognized the academic research achievements ... Young Researcher of the Year Awards. , The ... Convention Centre and in conjunction with the ARMS ... Australia,s and New Zealand,s scientific community. Guest of ...
(Date:9/18/2014)... their entire lives nestling in the protective tentacles of ... they sometimes travel hundreds of kilometres across the open ... fish has been predicted, this is the first time ... populations has been observed. , Dr Steve Simpson, Senior ... University of Exeter, and colleagues from the Australian Research ...
(Date:9/17/2014)... Fauna Europaea started in 2000 as an EC-FP5 four-year ... years of steady progress and successful participations in several ... European Biodiversity Observation Network project (EU BON), to ... the contributors and to extend the general dissemination of ... Journal has applied its novel e-Publishing tools ...
Breaking Biology News(10 mins):Elsevier and Australasian Research Management Society award scientists at Scopus ceremony 2Expedition finds Nemo can travel great distances to connect populations 2Expedition finds Nemo can travel great distances to connect populations 3Contributions on Fauna Europaea: Data papers as innovative model on expert involvement 2
... methodology for governments and corporations to determine the availability ... Environmental Science & Technology . In "Methodology of ... scarce metals using a methodology that determines their supply ... "In the past few years, a number of ...
... as cooking with carbon spaghetti: A Kansas State University ... with carbon nanotubes -- ultrasmall tubes that look like ... -- made of graphene, an atom-thick sheet of carbon ... and rechargeable batteries, according to research by Gurpreet Singh, ...
... nasty shocks. Economies can crash, fisheries can collapse, and climates ... currently requires the collection of enormous and often prohibitive amounts ... the Max-Planck-Institute for the Physics of Complex Systems in Germany ... UK could change this. In a paper published in the ...
Cached Biology News:New methodology assesses risk of scarce metals 2The right recipe: Engineering research improves laser detectors, batteries 2The right recipe: Engineering research improves laser detectors, batteries 3Predicting system crashes in nature and society 2
(Date:9/18/2014)... 18, 2014  MEI Pharma, Inc. (Nasdaq: MEIP ... novel therapies for cancer, announced today that Daniel P. ... at BioCentury,s NewsMakers in the Biotech Industry conference ... from the Millennium Broadway Hotel & Conference Center in ... presentation can be accessed at www.meipharma.com . A replay ...
(Date:9/18/2014)... ST. LOUIS , Sept. 18, 2014 /PRNewswire/ ... ) announced today it has entered into a ... Michigan (U-M) Medical School,s Vector Core. Under the ... Sigma CRISPR technology, experimental design consultation, and dedicated ... poised to accelerate gene editing-based research at the ...
(Date:9/18/2014)... Now a team led by an engineer at Michigan ... that will let scientists slash the cost of one ... Syringe pumps are used to dispatch precise amounts of ... a reaction. They can also cost hundreds or even ... of Michigan Tech students published the library of free ...
(Date:9/18/2014)... The quest for the ultimate memory device for computing ... at The City College of New York led by ... exhibit both magnetic and ferroelectric properties. , Combining both ... can occur between them and for the devices that ... Combining these two properties in a single material, however, ...
Breaking Biology Technology:MEI Pharma To Present At BioCentury's NewsMakers Conference 2MEI Pharma To Present At BioCentury's NewsMakers Conference 3Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 2Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 3Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 4Doing science just got cheaper -- and faster 2Oxides discovered by CCNY team could advance memory devices 2
... California (USC) have, for the first time in history, derived ... will enable scientists to create far more effective animal models ... , The research will be published in the Dec. 26 ... is a major development in stem cell research because we ...
... bacteria. However, how the step from gene to anti-bacterial effect ... B. Pseudomallei, a bacterium suitable for bioweapons, had ... human body for many years without being detected by the ... throughout the body, resulting in the patient dying from blood ...
... researcher has created a compound that prevents replication of the ... for the disease. , "The outbreak of SARS in 2003 ... there is currently no treatment," said Arun Ghosh, the Purdue ... not currently a threat, there is the concern that SARS ...
Cached Biology Technology:USC researchers derive first embryonic stem cells from rats 2USC researchers derive first embryonic stem cells from rats 3Purdue researcher invents molecule that stops SARS 2Purdue researcher invents molecule that stops SARS 3
When added to either StemSep CD4+ or CD8+ T Cell Enrichment cocktails, human HLA-DR TAC is designed to deplete human HLA-DR from samples to isolate resting CD4+ or CD8+ T cells....
When added to either StemSep CD4+ or CD8+ T Cell Enrichment cocktails, human CD69 TAC is designed to deplete human CD69 from samples to isolate resting CD4+ or CD8+ T cells....
This kit is designed to select cells labeled with phycoerythrin- (PE-) conjugated antibodies. Kit includes reagents for labeling 3 x 10 9 cells and EasySep magnet....
No-Weigh Dithiothreitol (DTT) ,7.7 mg DTT/Tube x 48 tubes...
Biology Products: